Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Pomella A"'
Autor:
Matteo Cassandri, Antonella Porrazzo, Silvia Pomella, Beatrice Noce, Clemens Zwergel, Francesca Antonella Aiello, Francesca Vulcano, Luisa Milazzo, Simona Camero, Deborah Pajalunga, Massimo Spada, Valeria Manzi, Giovanni Luca Gravina, Silvia Codenotti, Michela Piccione, Miriam Tomaciello, Michele Signore, Giovanni Barillari, Cinzia Marchese, Alessandro Fanzani, Biagio De Angelis, Concetta Quintarelli, Christopher R. Vakoc, Eleanor Y. Chen, Francesca Megiorni, Franco Locatelli, Sergio Valente, Antonello Mai, Rossella Rota, Francesco Marampon
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-20 (2024)
Abstract Radiotherapy (RT) plays a critical role in the management of rhabdomyosarcoma (RMS), the prevalent soft tissue sarcoma in childhood. The high risk PAX3-FOXO1 fusion-positive subtype (FP-RMS) is often resistant to RT. We have recently demonst
Externí odkaz:
https://doaj.org/article/d2578a217b0d469480a398078bb622c7
Autor:
Simona Camero, Luisa Milazzo, Francesca Vulcano, Federica Ceccarelli, Paola Pontecorvi, Francesca Pedini, Alessandra Rossetti, Elena Sofia Scialis, Giulia Gerini, Fabrizio Cece, Silvia Pomella, Matteo Cassandri, Antonella Porrazzo, Enrico Romano, Claudio Festuccia, Giovanni Luca Gravina, Simona Ceccarelli, Rossella Rota, Lavinia Vittoria Lotti, Fabio Midulla, Antonio Angeloni, Cinzia Marchese, Francesco Marampon, Francesca Megiorni
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-24 (2024)
Abstract Background Despite a multimodal approach including surgery, chemo- and radiotherapy, the 5-year event-free survival rate for rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in childhood, remains very poor for metastatic patients,
Externí odkaz:
https://doaj.org/article/0b81896720af4a4a9845e88f03e04c18
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Pomella, Silvia1 (AUTHOR), Melaiu, Ombretta1 (AUTHOR), Cifaldi, Loredana1 (AUTHOR) silvia.pomella@uniroma2.it, Bei, Roberto1 (AUTHOR), Gargari, Marco1 (AUTHOR), Campanella, Vincenzo1 (AUTHOR), Barillari, Giovanni1 (AUTHOR) barillar@uniroma2.it
Publikováno v:
International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8929. 31p.
Autor:
Pomella, Silvia1 (AUTHOR) silvia.pomella@uniroma2.it, Melaiu, Ombretta1 (AUTHOR) ombretta.melaiu@uniroma2.it, Dri, Maria2 (AUTHOR) mariampdri6@gmail.com, Martelli, Mirko1 (AUTHOR) mirko.marte@libero.it, Gargari, Marco1 (AUTHOR) marco.gargari@gmail.com, Barillari, Giovanni1 (AUTHOR) barillar@uniroma2.it
Publikováno v:
Cells (2073-4409). Aug2024, Vol. 13 Issue 15, p1294. 26p.
Publikováno v:
In Fusion Engineering and Design July 2024 204
Autor:
Benjamin Z. Stanton, Silvia Pomella
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
We describe exciting recent advances in fusion-driven sarcoma etiology, from an epigenetics perspective. By exploring the current state of the field, we identify and describe the central mechanisms that determine sarcomagenesis. Further, we discuss s
Externí odkaz:
https://doaj.org/article/8ce7b0935d544010b6de22583b44a085
Autor:
Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J. Houghton, Francesco Marampon, Berkley E. Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor
Externí odkaz:
https://doaj.org/article/b02d638fdabc4c31acb1630b1acf4c96
Autor:
Silvia Pomella, Ombretta Melaiu, Maria Dri, Mirko Martelli, Marco Gargari, Giovanni Barillari
Publikováno v:
Cells, Vol 13, Iss 15, p 1294 (2024)
High levels of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-2 and angiopoietin (ANG)-2 are found in tissues from oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). As might be expected,
Externí odkaz:
https://doaj.org/article/223a259a01ed48c7b59230a2f8e84b40
Autor:
Franken, Amelie, Bila, Michel, Mechels, Aurelie, Kint, Sam, Van Dessel, Jeroen, Pomella, Valentina, Vanuytven, Sebastiaan, Philips, Gino, Bricard, Orian, Xiong, Jieyi, Boeckx, Bram, Hatse, Sigrid, Van Brussel, Thomas, Schepers, Rogier, Van Aerde, Cedric, Geurs, Sarah, Vandecaveye, Vincent, Hauben, Esther, Vander Poorten, Vincent, Verbandt, Sara, Vandereyken, Katy, Qian, Junbin, Tejpar, Sabine, Voet, Thierry, Clement, Paul M., Lambrechts, Diether
Publikováno v:
In Immunity 12 March 2024 57(3):541-558