Výsledky vyhledávání - "Polyxeni Alexiou"

Akademický článek

Patent Foramen Ovale Closure in Special Clinical Situations: More Questions Than Answers?

Autor: Anastasios Apostolos, Polyxeni Alexiou, Amalia Papanikolaou, Georgios Trantalis, Maria Drakopoulou, Nikolaos Ktenopoulos, Ioannis Kachrimanidis, Panayotis K. Vlachakis, Ismini Tsakiri, Grigorios Chrysostomidis, Konstantina Aggeli, Costas Tsioufis, Konstantinos Toutouzas

Publikováno v: Life, Vol 14, Iss 6, p 706 (2024)

Patent foramen ovale (PFO) is a remnant of the foetal circulation resulting from incomplete occlusion of the septum primum and septum secundum. Although prevalent in about 25% of the population, it mainly remains asymptomatic. However, its clinical s

Externí odkaz: https://doaj.org/article/7fee5cbfbb444f09b2b814b12547fd68

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Akademický článek

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Autor: Despoina Xidaki, Panagiota Agrafioti, Dimitra Diomatari, Archontia Kaminari, Eleftherios Tsalavoutas-Psarras, Polyxeni Alexiou, Vasilios Psycharis, Effie C. Tsilibary, Spyridon Silvestros, Marina Sagnou

Publikováno v: Materials, Vol 11, Iss 4, p 595 (2018)

The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed

Externí odkaz: https://doaj.org/article/010da01bdbb2477486e5a9a6565df0fc

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Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index

Autor: George Kontopidis, Polyxeni Alexiou, Elias Eliopoulos, Alexandros T. Strongilos, Elias A. Couladouros, Christos Papaneophytou, Vagelis Rinotas, Foteini Violitzi, Eleni Douni, Maria Dimitra Ouzouni, Athanasios Papakyriakou

Publikováno v: Journal of medicinal chemistry. 63(20)

Receptor activator of nuclear factor-κB ligand (RANKL) constitutes the master mediator of osteoclastogenesis, while its pharmaceutical inhibition by a monoclonal antibody has been approved for the treatment of postmenopausal osteoporosis. To date, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025f1539195fbd02559b7c5a33d74e00
https://pubmed.ncbi.nlm.nih.gov/32955874

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Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Autor: Polyxeni Alexiou, Kostas Politopoulos, M Zachariadis, Barbara Mavroidi, Maria Pelecanou, K Koutsonikoli, Marina Sagnou, Eleni Alexandratou, K T Kazantzis

Publikováno v: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 19(2)

Photodynamic therapy (PDT) is a minimally invasive approach to treat various forms of cancer, based on the ability of certain non-toxic molecules (photosensitizers) to generate reactive oxygen species (ROS) after excitation by light of a certain wave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32253bd8eea8909a1fee5cfe5adbe2d
https://pubmed.ncbi.nlm.nih.gov/31956888

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Aqueous Solubility Enhancement for Bioassays of Insoluble Inhibitors and QSPR Analysis: A TNF-α Study

Autor: Anna Maranti, George Kontopidis, Christos Papaneophytou, Anthi Mettou, Antreas Afantitis, Polyxeni Alexiou, Elias Eliopoulos, Elias A. Couladouros, Fotini Liepouri, Georgia Melagraki, Athanasios Papakyriakou

Publikováno v: SLAS Discovery. 23:84-93

The aim of this study is to improve the aqueous solubility of a group of compounds without interfering with their bioassay as well as to create a relevant prediction model. A series of 55 potential small-molecule inhibitors of tumor necrosis factor-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0f9fb931b1ed199349eaf27c82ef58
https://doi.org/10.1177/2472555217712507

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Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin

Autor: Ekaterina S. Ivanova, Victor S. Stroylov, Maria Pelecanou, Polyxeni Alexiou, Victor V. Tatarskiy, Marina Sagnou, Murad Vagida, Fedor N. Novikov, Alexander A. Shtil, Ilya Yu. Titov, Ghermes G. Chilov

Publikováno v: European Journal of Medicinal Chemistry. 198:112331

The MDR1/P-glycoprotein (Pgp)/ABCB1 multidrug transporter is being investigated as a druggable target for antitumor therapy for decades. The natural product curcumin is known to provide an efficient scaffold for compounds capable of blocking Pgp medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c457a93c0c1732b8c1f9dc8fee7803
https://doi.org/10.1016/j.ejmech.2020.112331

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Synthesis and biological evaluation of potential small moleculeinhibitors of tumor necrosis factor

Autor: Fotini Liepouri, Christos Papaneophytou, Anna Maranti, Polyxeni Alexiou, Elias A. Couladouros, Anthi Mettou, Eleni Douni, Evangelos Ntougkos, George Kontopidis, Elias Eliopoulos, Alexandros T. Strongilos, George Kollias, Athanasios Papakyriakou, Katerina Tsiliouka

Publikováno v: MedChemComm. 6:1196-1209

Inhibition of tumor necrosis factor (TNF) production or function by small molecules has become a major focus in the pharmaceutical industry for the treatment of rheumatoid arthritis. In this study, a series of 39 novel SPD-304 analogs were designed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4189dc4479872feb05440b9406443984
https://doi.org/10.1039/c5md00023h

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Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films: concentration effect and release studies

Autor: Polyxeni Alexiou, Maria Pelecanou, Dimitrios A. Lamprou, David Mallinson, V. García Fernández-Luna, Alexander B. Mullen, Marina Sagnou, Ibrahim Khadra

Publikováno v: Fernández-Luna, V G, Mallinson, D, Alexiou, P, Khadra, I, Mullen, A B, Pelecanou, M, Sagnou, M & Lamprou, D A 2017, ' Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films: concentration effect and release studies ' RSC Advances, vol. 7, no. 21, pp. 12945-12952 . DOI: 10.1039/c6ra28163j

Formation of ordered porous polymer films is one of the techniques currently under investigation for its potential for the manufacturing of coatings with biomedical applications. Aiming for films with improved characteristics against bacterial coloni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5791a48a75812f73caba082bdb78751f

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Rationally Designed Less Toxic SPD-304 Analogs and Preliminary Evaluation of Their TNF Inhibitory Effects

Autor: Fotini Liepouri, Katerina Tsiliouka, George Kontopidis, Sotiria Chaitidou, Elias Eliopoulos, Eleni Douni, Alexandros T. Strongilos, Ioannis A. Katsoulis, Anthi Mettou, Elias A. Couladouros, Polyxeni Alexiou, Evangelos Ntougkos, Athanasios Papakyriakou, Christos Papaneophytou, Anna Maranti, George Kollias

Publikováno v: Archiv der Pharmazie. 347:798-805

SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic 3-alkylindole moi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::212c9169e17329104de7057a89a8cb4a
https://doi.org/10.1002/ardp.201400198

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