Zobrazeno 1 - 10
of 7 845
pro vyhledávání: '"Polysome"'
Autor:
Rosario Francisco-Velilla, Salvador Abellan, Juan Antonio Garcia-Martin, Juan Carlos Oliveros, Encarnacion Martinez-Salas
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 23-34 (2024)
GEMIN5 is a multifunctional protein involved in various aspects of RNA biology, including biogenesis of snRNPs and translation control. Reduced levels of GEMIN5 confer a differential translation to selective groups of mRNAs, and biallelic variants re
Externí odkaz:
https://doaj.org/article/f01c44795ddc421a916214668f534734
Autor:
Lucie Aumailley, Antoine Bodein, Pauline Adjibade, Mickaël Leclercq, Sylvie Bourassa, Arnaud Droit, Rachid Mazroui, Michel Lebel
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-22 (2024)
Abstract Background Vitamin C (ascorbate) is a water-soluble antioxidant and an important cofactor for various biosynthetic and regulatory enzymes. Mice can synthesize vitamin C thanks to the key enzyme gulonolactone oxidase (Gulo) unlike humans. In
Externí odkaz:
https://doaj.org/article/9c15dad6bae640a6b2297214fa5e6ee9
Autor:
Eva Martin-Solana, Irene Diaz-Lopez, Yamina Mohamedi, Ivan Ventoso, Jose-Jesus Fernandez, Maria Rosario Fernandez-Fernandez
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106488- (2024)
Given their highly polarized morphology and functional singularity, neurons require precise spatial and temporal control of protein synthesis. Alterations in protein translation have been implicated in the development and progression of a wide range
Externí odkaz:
https://doaj.org/article/1c6a58c940e74cd48db0cbbcab08e5a8
Autor:
Inci S. Aksoylu, Pauline Martin, Francis Robert, Krzysztof J. Szkop, Nicholas E. Redmond, Srirupa Bhattacharyya, Jennifer Wang, Shan Chen, Roberta L. Beauchamp, Irene Nobeli, Jerry Pelletier, Ola Larsson, Vijaya Ramesh
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in the TSC1 or TSC2 genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric d
Externí odkaz:
https://doaj.org/article/057c7629fc914290bfd51a7dc5438070
Autor:
Aruana F. F. Hansel-Frose, Jens Allmer, Marcel Friedrichs, Hellen Geremias dos Santos, Bruno Dallagiovanna, Lucía Spangenberg
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Alternative polyadenylation (APA) increases transcript diversity through the generation of isoforms with varying 3′ untranslated region (3′ UTR) lengths. As the 3′ UTR harbors regulatory element target sites, such as miRNAs or RNA-binding prote
Externí odkaz:
https://doaj.org/article/e53cb534858b420da0b9ff411415312c
Autor:
Anwesha Dasgupta, Ricardo A. Urquidi Camacho, Ramya Enganti, Sung Ki Cho, Lindsey L. Tucker, John S. Torreverde, Paul E. Abraham, Albrecht G. vonArnim
Publikováno v:
Plant Direct, Vol 8, Iss 1, Pp n/a-n/a (2024)
Abstract The eukaryote‐specific ribosomal protein of the small subunit eS6 is phosphorylated through the target of rapamycin (TOR) kinase pathway. Although this phosphorylation event responds dynamically to environmental conditions and has been stu
Externí odkaz:
https://doaj.org/article/16b57e64fb894ffdb8c0804d627dffbb
Autor:
Marino Caruso, Sébastien Meurant, Damien Detraux, Amandine Mathieu, Manon Gilson, Marc Dieu, Antoine Fattaccioli, Catherine Demazy, Mustapha Najimi, Etienne Sokal, Thierry Arnould, Catherine Verfaillie, Denis L.J. Lafontaine, Patricia Renard
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 254-268 (2023)
Summary: Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic d
Externí odkaz:
https://doaj.org/article/ee12d780943e4a26ba8afbf1d2114e94
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2013 (2024)
Understanding the intricate molecular mechanisms governing the fate of human adipose-derived stem cells (hASCs) is essential for elucidating the delicate balance between adipogenic and osteogenic differentiation in both healthy and pathological condi
Externí odkaz:
https://doaj.org/article/bcc07efa41184100960efc6be9ad90d6
Autor:
Tingzeng Wang, Shuangmei Tian, Elena B. Tikhonova, Andrey L. Karamyshev, Jing J. Wang, Fangyuan Zhang, Degeng Wang
Publikováno v:
Biology, Vol 12, Iss 12, p 1536 (2023)
miRNAs moderately inhibit the translation and enhance the degradation of their target mRNAs via cognate binding sites located predominantly in the 3′-untranslated regions (UTR). Paradoxically, miRNA targets are also polysome-associated. We studied
Externí odkaz:
https://doaj.org/article/5a3aee420547450189453dbedb6c61eb
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels. Either def
Externí odkaz:
https://doaj.org/article/93fa1466e5554a70a7459434dee79f0e