Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3

Autor: Fanping Wang, Yanwei Sun, Xiaoyu Huang, Caijuan Qiao, Wenrui Zhang, Peijun Liu, Mingyong Wang

Publikováno v: AMB Express, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Sulforaphane (SFN), an active compound in cruciferous vegetables, has been characterized by its antiproliferative capacity. We investigated the role and molecular mechanism through which SFN regulates proliferation and self-renewal of lung c

Externí odkaz: https://doaj.org/article/8be10a185f7648b4b13930d6fbbcac3e

Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3.

Autor: Wang, Fanping^1,2 (AUTHOR), Sun, Yanwei¹ (AUTHOR), Huang, Xiaoyu¹ (AUTHOR), Qiao, Caijuan¹ (AUTHOR), Zhang, Wenrui¹ (AUTHOR), Liu, Peijun² (AUTHOR) liupeijun@xjtu.edu.cn, Wang, Mingyong^1,3 (AUTHOR) wangfanping118@126.com

Publikováno v: AMB Express. 8/23/2021, Vol. 11 Issue 1, p1-10. 10p.

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization.

Autor: Gemeinhardt TM; Montreal Clinical Research Institute (IRCM), Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada., Regy RM; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA., Mendiola AJ; Department of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA., Ledterman HJ; Department of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA., Henrickson A; Department of Chemistry and Biochemistry, The University of Lethbridge, Lethbridge, AB, Canada., Phan TM; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA., Kim YC; Center for Materials Physics and Technology, Naval Research Laboratory, Washington, DC 20375, USA., Demeler B; Department of Chemistry and Biochemistry, The University of Lethbridge, Lethbridge, AB, Canada.; Department of Chemistry, University of Montana, Missoula, MT, United States., Kim CA; Department of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA., Mittal J; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.; Department of Chemistry, Texas A&M University, College Station, TX, USA.; Interdisciplinary Graduate Program in Genetics and Genomics, Texas A&M University, College Station, TX, USA., Francis NJ; Montreal Clinical Research Institute (IRCM), Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 27. Date of Electronic Publication: 2023 Oct 27.

Evidence That Strong Positive Selection Drives Neofunctionalization in the Tandemly Duplicated Polyhomeotic Genes in Drosophila

Autor: Beisswanger, Steffen, Stephan, Wolfgang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2008 Apr 01. 105(14), 5447-5452.

Externí odkaz: https://www.jstor.org/stable/25461624

Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity

Autor: Alexander Kaltashov, Elodie L. Boulier, Jin Joo Kang, Elias Seif, Chongwoo A. Kim, Charles Sasseville, Ibani Kapur, Olga Senkovich, Nicole J. Francis

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications

Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive Complex 1 (PRC1) subunit Polyhomeotic (Ph) has been shown to play an important role in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0d91e76d90bef838a1946fc4975677
http://link.springer.com/article/10.1038/s41467-020-19435-z