Zobrazeno 1 - 10
of 9 492
pro vyhledávání: '"Polygenic Risk"'
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Asthma and allergic diseases (such as allergic rhinitis) are multifactorial chronic respiratory diseases, and have many common pathogenic mechanisms. This study aimed to assess the joint effects of breastfeeding and genetic suscep
Externí odkaz:
https://doaj.org/article/60f95db2f7a643d49a329890d01a926f
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-11 (2024)
Abstract Background Loneliness has garnered significant attention globally, with extensive exploration of its association with cardiovascular disease. However, a notable research gap persists concerning loneliness and its potential link to atrial fib
Externí odkaz:
https://doaj.org/article/cf40723e5a364e6f88e364511d17affd
Autor:
Zijie Zhao, Tim Gruenloh, Meiyi Yan, Yixuan Wu, Zhongxuan Sun, Jiacheng Miao, Yuchang Wu, Jie Song, Qiongshi Lu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background Polygenic risk score (PRS) is a major research topic in human genetics. However, a significant gap exists between PRS methodology and applications in practice due to often unavailable individual-level data for various PRS tasks in
Externí odkaz:
https://doaj.org/article/7215d93b706c42faab8e813e4ae4fdaa
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background The majority of men referred with a raised PSA for suspected prostate cancer will receive unnecessary tertiary investigations including MRI and biopsy. Here, we compared different types of biomarkers to refine tertiary referrals a
Externí odkaz:
https://doaj.org/article/940d450a9266478ea32be48d83014378
Autor:
Wenyu Song, Max Lam, Ruize Liu, Aurélien Simona, Scott G. Weiner, Richard D. Urman, Kenneth J. Mukamal, Adam Wright, David W. Bates
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Opioid prescription records in existing electronic health record (EHR) databases are a potentially useful, high-fidelity data source for opioid use-related risk phenotyping in genetic analyses. Prescriptions for codeine derived from EHR reco
Externí odkaz:
https://doaj.org/article/dbd1f44fbf3d4eb8a178fda1a7c038e8
Autor:
Stearns, Stephen C., author, Medzhitov, Ruslan, author
Publikováno v:
Evolutionary Medicine, 2024, ill.
Externí odkaz:
https://doi.org/10.1093/oso/9780192871978.003.0015
Autor:
Sheng-Chun Hung, Li-Wen Chang, Tzu-Hung Hsiao, Chia-Yi Wei, Shian-Shiang Wang, Jian-Ri Li, I-Chieh Chen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Although prostate cancer is a common occurrence among males, the relationship between existing risk prediction models remains unclear. The objective of this hospital-based retrospective study is to investigate the impact of polygenic risk sc
Externí odkaz:
https://doaj.org/article/8def721121954e0caca97dbc64eaaddf
Autor:
Dayeon Shin
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Introduction Metabolic syndrome is a chronic disease associated with multiple comorbidities. Over the last few years, machine learning techniques have been used to predict metabolic syndrome. However, studies incorporating demographic, clini
Externí odkaz:
https://doaj.org/article/88651f35e24a4260bd4ec819afef2368
Autor:
Yu Zhang, Chao Sheng, Zhangyan Lyu, Hongji Dai, Fangfang Song, Fengju Song, Yubei Huang, Kexin Chen
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 8, Pp 712-723 (2024)
Objective: Few studies have evaluated the benefits of colorectal cancer (CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model (QCancer-10) and a 139-variant polygenic ris
Externí odkaz:
https://doaj.org/article/978bfc13fc3d46bfa52245841d44af5d
Autor:
Kira Trares, Hannah Stocker, Joshua Stevenson-Hoare, Laura Perna, Bernd Holleczek, Konrad Beyreuther, Ben Schöttker, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Polygenic risk scores (PRS) and subjective cognitive decline (SCD) are associated with the risk of developing dementia. It remains to examine whether they can improve the established cardiovascular risk factors aging and dementia
Externí odkaz:
https://doaj.org/article/2dd30935939c4e65bc30c566b652366b