Self-assembled mPEG-hexPLA polymeric nanocarriers for the targeted cutaneous delivery of imiquimod

Autor: Robert Gurny, Yogeshvar N. Kalia, Michael Möller, Margaux Mignot, Maria Lapteva, Karine Mondon

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 142 (2019) pp. 553-562

mPEG-hexPLA micelles have shown their ability to improve delivery and cutaneous bioavailability of a wide range of poorly water soluble and lipophilic molecules. Although poorly water soluble, imiquimod (IMQ) is only moderately lipophilic and it was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1d875b5647f6f2389aae6e1fccac39
https://doi.org/10.1016/j.ejpb.2019.01.008

Live-cell epigenome manipulation by synthetic histone acetylation catalyst system

Autor: Fujiwara, Y., Yamanashi, Y., Fujimura, A., Sato, Y., Kujirai, T., Kurumizaka, H., Kimura, Hiroshi, Yamatsugu, K., Kawashima, S. A., Kanai, M.

Publikováno v: Proc Natl Acad Sci U S A

Chemical modifications of histones, such as lysine acetylation and ubiquitination, play pivotal roles in epigenetic regulation of gene expression. Methods to alter the epigenome thus hold promise as tools for elucidating epigenetic mechanisms and as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095b3422aa28ded3199931dbfd6c44fe
https://doi.org/10.1073/pnas.2019554118

Electro-spun PLA-PEG-yarns for tissue engineering applications

Autor: Thomas Schneiders, Marc Greuel, Franziska Kreimendahl, Magnus Kruse, Thomas Gries, Stefan Jockenhoevel, Benedict Bauer

Publikováno v: Biomedizinische Technik, 63(3), 231-243. De Gruyter

Electro-spinning is widely used in tissue-engineered applications mostly in form of non-woven structures. The development of e-spun yarn opens the door for textile fabrics which combine the micro to nanoscale dimension of electro-spun filaments with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d34fd346508dc5e7d986764f7058057
https://doi.org/10.1515/bmt-2017-0232

PET imaging with copper-64 as a tool for real-time in vivo investigations of the necessity for cross-linking of polymeric micelles in nanomedicine

Autor: Palle Rasmussen, Andreas Tue Ingemann Jensen, Pramod Kumar Ek, Tina Binderup, Constance E Grandjean, Thomas Lars Andresen, Andreas Kjaer

Publikováno v: Jensen, A I, Binderup, T, Ek, P K, Grandjean, C E, Rasmussen, P H, Kjaer, A & Andresen, T L 2017, ' PET imaging with copper-64 as a tool for real-time in vivo investigations of the necessity for cross-linking of polymeric micelles in nanomedicine ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 8, pp. 366-374 . https://doi.org/10.1002/jlcr.3510

Polymeric micelles in nanomedicine are often cross-linked to prevent disintegration in vivo. This typically requires clinically problematic chemicals or laborious procedures. In addition, cross-linking may interfere with advanced release strategies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e36bed81f774910a4365a1ec522d91
https://doi.org/10.1002/jlcr.3510

Two-Dimensional Antifouling Fluidic Channels on Nanopapers for Biosensing

Autor: Orlando J. Rojas, Hannes Orelma, Maryam Borghei, Maija Vuoriluoto, Risto Koivunen, Katariina Solin

Publikováno v: Solin, K, Orelma, H, Borghei, M, Vuoriluoto, M, Koivunen, R & Rojas, O J 2019, ' Two-Dimensional Antifouling Fluidic Channels on Nanopapers for Biosensing ', Biomacromolecules, vol. 20, no. 2, pp. 1036-1044 . https://doi.org/10.1021/acs.biomac.8b01656
Biomacromolecules

openaire: EC/H2020/760876/EU//INNPAPER Two-dimensional (hydrophilic) channels were patterned on films prepared from cellulose nanofibrils (CNF) using photolithography and inkjet printing. Such processes included UV-activated thiol-yne click coupling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fe6a135477b0144c609e8dd10b1e04
https://aaltodoc.aalto.fi/handle/123456789/36679