Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Polycythemia/genetics"'
Autor:
Abdul Ghani Alattar, Shamit Soneji, Ramprasad Ramakrishnan, Alexander Mattebo, Sofie Singbrant, Jenny Hansson, Johan Flygare, Stefan Lang, Emile van den Akker, Marcus Järås, Maria Jassinskaja, Kristýna Pimková, Isabel Prieto González-Albo, Taha Sen
Publikováno v:
Scientific reports, 11(1). Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family gene orthologs in mouse and human, is highly and specifically expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e58782fc469dc262a9ac06c0c4cab84
https://doi.org/10.1038/s41598-021-95291-1
https://doi.org/10.1038/s41598-021-95291-1
Autor:
Patrick H. Maxwell, Peter A. Robbins, Thomas G. Smith, Keith L. Dorrington, Nick P. Talbot, George M. Balanos
Publikováno v:
Talbot, N P, Smith, T G, Balanos, G M, Dorrington, K L, Maxwell, P H & Robbins, P A 2017, ' Cardiopulmonary phenotype associated with human PHD2 mutation ', Physiology Reports, vol. 5, no. 7, e13224 . https://doi.org/10.14814/phy2.13224
Oxygen-dependent regulation of the erythropoietin gene is mediated by the hypoxia-inducible factor (HIF) family of transcription factors. When oxygen is plentiful, HIF undergoes hydroxylation by a family of oxygen-dependent prolyl hydroxylase domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85feb9701ab9b84834151c2c34eb05f5
https://doi.org/10.14814/phy2.13224
https://doi.org/10.14814/phy2.13224
Autor:
Kathrin Geiger, Ben Wielockx, Guo-Hua Fong, Georg Breier, Vasuprada Iyengar, David M. Poitz, Max Gassmann, Gustavo B. Baretton, Joanna Kalucka, David R. Greaves, Teresa Otto, Alex M. Sykes, Alexander Weidemann, S. Bergmann, Steffen Jahn, Antje Muschter, Kristin Franke, Joachim Fandrey, Stefan R. Bornstein, Michael H. Muders, Rashim Pal Singh, Soulafa Mamlouk, Triantafyllos Chavakis, Kathrin Wieczorek, Tatsiana Ripich
Publikováno v:
BLOOD
Franke, K, Kalucka, J, Mamlouk, S, Singh, R P, Muschter, A, Weidemann, A, Iyengar, V, Jahn, S, Wieczorek, K, Geiger, K, Muders, M, Sykes, A M, Poitz, D M, Ripich, T, Otto, T, Bergmann, S, Breier, G, Baretton, G, Fong, G-H, Greaves, D R, Bornstein, S, Chavakis, T, Fandrey, J, Gassmann, M & Wielockx, B 2013, ' HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis ', Blood, vol. 121, no. 8, pp. 1436-45 . https://doi.org/10.1182/blood-2012-08-449181
Franke, K, Kalucka, J, Mamlouk, S, Singh, R P, Muschter, A, Weidemann, A, Iyengar, V, Jahn, S, Wieczorek, K, Geiger, K, Muders, M, Sykes, A M, Poitz, D M, Ripich, T, Otto, T, Bergmann, S, Breier, G, Baretton, G, Fong, G-H, Greaves, D R, Bornstein, S, Chavakis, T, Fandrey, J, Gassmann, M & Wielockx, B 2013, ' HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis ', Blood, vol. 121, no. 8, pp. 1436-45 . https://doi.org/10.1182/blood-2012-08-449181
Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible factor (HIF). Accumulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c79ef7bba05eef98921d151168a740
https://hdl.handle.net/20.500.12866/10391
https://hdl.handle.net/20.500.12866/10391
