Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Polycystin-2"'
Autor:
Marie C. Hogan, Christopher J. Ward
Publikováno v:
Extracellular Vesicle, Vol 4, Iss , Pp 100048- (2024)
Autosomal dominant polycystic kidney (ADPKD) disease is the commonest genetic cause of kidney failure (affecting 1:800 individuals) and is due to heterozygous germline mutations in either of two genes, PKD1 and PKD2. Homozygous germline mutations in
Externí odkaz:
https://doaj.org/article/5bb8d547eb204f1ebab4f4f9be7b7af8
Autor:
Qin, Xiao-dan a, b, 1, Liang, Jian-feng a, c, 1, Gan, Lin-yu a, d, 1, Peng, Ke-shan a, e, Huang, Xue-hong a, e, Li, Xiao-ting a, e, Chen, Jin-li a, e, Li, Wan e, Zhang, Lei f, Jian, Jie a, e, Lu, Jun a, e, ⁎
Publikováno v:
In BBA - Molecular Cell Research February 2025 1872(2)
Akademický článek
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Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/1e387653e4794f19a3d78b44fea4d97d
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Polycystin-2 (PC2), which is a transmembrane protein encoded by the PKD2 gene, plays an important role in kidney disease, but its role in lipopolysaccharide (LPS)-induced acute lung injury (ALI) is unclear. We overexpressed PKD2 in lung epit
Externí odkaz:
https://doaj.org/article/3c507fa37b35441fb6bef1baec283823
Autor:
Noelia Scarinci, Brenda C. Gutierrez, Virginia H. Albarracín, María del Rocío Cantero, Horacio F. Cantiello
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The primary cilium is a non-motile sensory organelle that transduces environmental cues into cellular responses. It comprises an axoneme, a core of nine doublet microtubules (MTs) coated by a specialized membrane populated by receptors, and a high de
Externí odkaz:
https://doaj.org/article/22c5d47efdc044afb5c9e1a4574b73fc
Publikováno v:
Cells, Vol 13, Iss 7, p 610 (2024)
Autosomal dominant polycystic kidney disease (ADPKD) occurs when the proteins Polycystin-1 (PC1, PKD1) and Polycystin-2 (PC2, PKD2) contain mutations. PC1 is a large membrane receptor that can interact and form a complex with the calcium-permeable ca
Externí odkaz:
https://doaj.org/article/2dd6adcf9a854f74b39e13eb014eab9f
Akademický článek
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Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Polycystin-1 (PC1) is an 11-transmembrane (TM) domain-containing protein encoded by the PKD1 gene, the most frequently mutated gene leading to autosomal dominant polycystic kidney disease (ADPKD). This large (> 462 kDal) protein has a complex posttra
Externí odkaz:
https://doaj.org/article/3f88e2bf8c6a468ebdb5449ff7574023
Autor:
Wendy A. Lea, Thomas Winklhofer, Lesya Zelenchuk, Madhulika Sharma, Jessica Rossol-Allison, Timothy A. Fields, Gail Reif, James P. Calvet, Jason L. Bakeberg, Darren P. Wallace, Christopher J. Ward
Publikováno v:
Cells, Vol 12, Iss 17, p 2166 (2023)
The PKD1 gene, encoding protein polycystin-1 (PC1), is responsible for 85% of cases of autosomal dominant polycystic kidney disease (ADPKD). PC1 has been shown to be present in urinary exosome−like vesicles (PKD−ELVs) and lowered in individuals w
Externí odkaz:
https://doaj.org/article/cb0efb4fcbe4484790ed4e7ad2759ca2