Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Polyclonal B cell response"'
Autor:
Kim L. Good-Jacobson, Lucy Cooper
Publikováno v:
Immunology & Cell Biology. 98:456-466
Chronic viral infections disrupt the ability of the humoral immune response to produce neutralizing antibody or form effective immune memory, preventing viral clearance and making vaccine design difficult. Multiple components of the B-cell response a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18516846c1ec0d29bc39cadb4fb0e1c
https://doi.org/10.1111/imcb.12338
https://doi.org/10.1111/imcb.12338
Autor:
Andrea| Hernández Valverde, Carlos León Céspedes, Carlos I. Quesada Aguilar, Fabiola Fuentes Alfaro
Publikováno v:
Revista Clínica Escuela de Medicina UCR-HSJD. 10:28-35
El síndrome de Sjögren primario es una enfermedad autoinmune sistémica que afecta principalmente glándulas exocrinas y confiere un mayor riesgo de presentar linfomas comparado con la población general e incluso con otras enfermedades autoinmunes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436d72db7f0a57a3e7d7b43cfba85b49
https://doi.org/10.15517/rc_ucr-hsjd.v10i1.38290
https://doi.org/10.15517/rc_ucr-hsjd.v10i1.38290
Autor:
Changze Han, Michael Pentella, Mohammad Fili, Natalie Ruggio, Guiping Hu, Grant D. Brown, J. Brooks Jackson, Kristina M. Sevcik, Kai J. Rogers, Tom Gallagher, Wendy Maury, Hanora A Van Ert, Nathan Schwery, C. Michael Knudson, Spencer Dempewolf, Anthony Roberth Rojas Chavez, Anna E. Merrill, Devlin Boyt, Dana Bohan, Enya Qing, Hillel Haim
Publikováno v:
Microbiology Spectrum. 10
The spike protein of SARS-CoV-2 is arranged as a trimer on the virus surface, composed of three S1 and three S2 subunits. Infected and vaccinated individuals generate antibodies against spike, which can neutralize the virus. Most antibodies target th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb9c2f8821dafa6d15e6899216626fd
https://doi.org/10.1128/spectrum.02676-21
https://doi.org/10.1128/spectrum.02676-21
Autor:
Yu-Shan Tseng, J. Kennon Smith, Mario Mietzsch, Aravind Asokan, Robert McKenna, Shanan N Emmanuel, Mavis Agbandje-McKenna, Jane Hsi, Matias Kaplan, Paul R. Chipman
Publikováno v:
J Virol
Adeno-associated viruses (AAV) serve as vectors for therapeutic gene delivery. AAV9 vectors have been FDA approved, as Zolgensma, for the treatment of spinal muscular atrophy and are being evaluated in clinical trials for the treatment of neurotropic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1481ded89cf7a846c284dde2447310
https://europepmc.org/articles/PMC8827038/
https://europepmc.org/articles/PMC8827038/
Autor:
Mark J. Mulligan, Amber Cornelius, Marie I. Samanovic, Belinda M Dcosta, Nathaniel R. Landau, Hao Zhou, Ramin S. Herati, Takuya Tada
Recently identified SARS-CoV-2 variants Mu and C.1.2 have mutations in the receptor binding domain and N- and C-terminal domains that might confer resistance to natural and vaccine-elicited antibody. Analysis with pseudotyped lentiviruses showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b63e479198cfddb41e49a54282bc2fa
https://doi.org/10.1101/2021.10.19.463727
https://doi.org/10.1101/2021.10.19.463727
Autor:
Margaret E. Ackerman, Andrés Finzi, Marzena Pazgier, Sherry Stanfield-Oakley, Guillaume Beaudoin-Bussières, Rebekah Sherburn, William D. Tolbert, Andrew P Hederman, Marina Tuyishime, Suneetha Gottumukkala, Guido Ferrari
Publikováno v:
Vaccines
Vaccines, Vol 9, Iss 975, p 975 (2021)
Volume 9
Issue 9
Vaccines, Vol 9, Iss 975, p 975 (2021)
Volume 9
Issue 9
The generation of a potent vaccine for the prevention and/or control of HIV-1 has been unsuccessful to date, despite decades of research. Existing evidence from both infected individuals and clinical trials support a role for non-neutralizing or weak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30faeed35fcfc3b64712a8367679883a
http://europepmc.org/articles/PMC8472903
http://europepmc.org/articles/PMC8472903
Autor:
Theodore A Gobillot, Vrasha Chohan, Ruth Nduati, Laura E Doepker, Julie Overbaugh, Hannah L. Itell, Brianna Hennessy, Cassandra A. Simonich, Evan M. Cale, Nicole A. Doria-Rose, Meghan Garrett, Mackenzie M. Shipley
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 6, Pp 100314-(2021)
Cell Reports Medicine, Vol 2, Iss 6, Pp 100314-(2021)
Summary Increasing evidence suggests infants develop unique neutralizing antibody (nAb) responses to HIV compared to adults. Here, we dissected the nAb response of an infant whose virus is in clinical trials as a vaccine immunogen, with a goal of cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c54ec8db497f4e74156eea89711195
http://europepmc.org/articles/PMC8233660
http://europepmc.org/articles/PMC8233660
Publikováno v:
Cell Host & Microbe
B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5994507b5e019285762d5cd30f8514
https://doi.org/10.1016/j.chom.2020.09.010
https://doi.org/10.1016/j.chom.2020.09.010
Autor:
Yiska Weisblum, Christopher O. Barnes, Fabian Schmidt, Davide F. Robbiani, Allison J. Greaney, Marianna Agudelo, Tyler N. Starr, Jesse D. Bloom, Zijun Wang, Marina Caskey, Frauke Muecksch, Shlomo Finkin, Daniel Poston, Paul D. Bieniasz, Michel C. Nussenzweig, Theodora Hatziioannou, Christian Gaebler, Pamela J. Bjorkman
Publikováno v:
Nature Communications
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e838e15e9cc9381883aa43b2498be99
https://doi.org/10.1101/2021.03.17.435863
https://doi.org/10.1101/2021.03.17.435863
Autor:
Shlomo Finkin, Fabian Schmidt, Christopher O. Barnes, Theodora Hatziioannou, Frauke Muecksch, Michel C. Nussenzweig, Christian Gaebler, Yiska Weisblum, Marianna Agudelo, Zijun Wang, Marina Caskey, Davide F. Robbiani, Daniel Poston, Tyler N. Starr, Alice Cho, Jesse D. Bloom, Allison J. Greaney, Pamela J. Bjorkman, Paul D. Bieniasz
Publikováno v:
Nature Communications
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dee31288f1f2e0370b41397d0ca5b4