Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Polyamine Synthesis Inhibition"'
Autor:
Lucía González Gutiérrez
Colorectal cancer is one of the most prevalent and deadly forms of cancer, particularly in Spain. Ongoing clinical trials are aimed at preventing colorectal cancer, especially in those patients at high risk. Combination of difluoromethylornithine (DF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15268bdc5495aacd1b9aaddeab7e3b2
https://doi.org/10.35376/10324/39406
https://doi.org/10.35376/10324/39406
Autor:
Sebastian Albinsson, Catarina Rippe, Lo Persson, Mario Grossi, Bengt-Olof Nilsson, Amalia Forte, Karl Swärd, Otto Phanstiel, Per Hellstrand, Azra Alajbegovic
Publikováno v:
Journal of Cellular Physiology. 231:1334-1342
Increased vascular smooth muscle cell (VSMC) proliferation is a factor in atherosclerosis and injury-induced arterial (re) stenosis. Inhibition of polyamine synthesis by α-difluoro-methylornithine (DFMO), an irreversible inhibitor of ornithine decar
Autor:
Maribel Antonello Rubin, Carlos Fernando Mello, John M. Littleton, Rukhsana Sultana, Susan Barron, D. Allan Butterfield
Publikováno v:
Alcoholism: Clinical and Experimental Research. 31:887-894
Background: Ethanol exposure and withdrawal during central nervous system development can cause oxidative stress and produce severe and long-lasting behavioral and morphological alterations in which polyamines seem to play an important role. However,
Autor:
Rodney C. Diaz, Karen Jo Doyle, Michael Anne Gratton, Ebenezer N. Yamoah, Weihong Feng, Liping Nie
Publikováno v:
Journal of Biological Chemistry. 280:15097-15102
l-α-Difluoromethylornithine (DFMO) is a chemopreventive agent for colon cancer in clinical trials. Yet, the drug produces an across-frequency elevation of the hearing threshold, suggesting that DFMO may affect a common trait along the cochlear spira
Publikováno v:
Journal of Vascular Research. 41:141-147
Vascular smooth muscle cell migration, occurring after intimal injury, is a substantial clinical problem in atherosclerosis and restenosis after stenting. Here we investigate the effects of polyamine synthesis inhibition on vascular smooth muscle cel
Autor:
Åke Sjöholm
Publikováno v:
Anti-Cancer Drugs. 4:259-264
The short-chain carboxylic acid sodium butyrate is known to induce differentiation in several cell systems. In this paper we have investigated the effect of sodium butyrate on the growth rate and hormone content and secretion in clonal rat insulinoma
Publikováno v:
Amino acids. 36(2)
Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC). Arginine may alternatively be metabolised to NO via NO synthase. Here we study if vascular smoo
Autor:
Dominique Fage, Carole Voltz, Bernard Scatton, Anna Porcella, Frédérique Bourdio, Jesus Benavides, C.J. Carter
Publikováno v:
Neurological Research. 14:181-183
N-Methyl-o-aspartate (NMD A) receptor activation selectively releases the poly amines spermine and spermidine from the rat striatum in vivo. The intrastriatal injection of spermine or spermidine is neurotoxicbut this toxicity is not blocked by MK-801
Publikováno v:
Scopus-Elsevier
The polyamines putrescine, spermidine and spermine, are ubiquitous intracellular metabolites associated with growth and protein synthesis. In this study effects of polyamine synthesis inhibition on bladder growth, polyamine levels and mechanical prop
Autor:
Shewan M. Aziz, Jack W. Olson, Pamela S. Newman, S. Tofiq, Santosh S. Arcot, Edward E. Soltis, David W. Lipke, Hongtao Guo
Publikováno v:
Clinical and experimental hypertension (New York, N.Y. : 1993). 19(3)
While a number of factors may initiate structural alterations within the cardiovascular system in response to hypertension, there are obligate cellular signaling mechanisms, such as the polyamines, through which they must operate. This study examined