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Akademický článek

A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy

Autor: Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-20 (2021)

Abstract Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to de

Externí odkaz: https://doaj.org/article/4e74d57df4f94a0fbb9a416bc7ae9cce

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Akademický článek

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Akademický článek

Peptide Vaccine Combined Adjuvants Modulate Anti-tumor Effects of Radiation in Glioblastoma Mouse Model

Autor: Thi-Anh-Thuy Tran, Young-Hee Kim, Thi-Hoang-Oanh Duong, Shin Jung, In-Young Kim, Kyung-Sub Moon, Woo-Youl Jang, Hyun-Ju Lee, Je-Jung Lee, Tae-Young Jung

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Glioblastoma, the most common aggressive cancer, has a poor prognosis. Among the current standard treatment strategies, radiation therapy is the most commonly recommended. However, it is often unsuccessful at completely eliminating the cancer from th

Externí odkaz: https://doaj.org/article/6795bd6af7004fed9384f30e1803b458

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Akademický článek

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Akademický článek

A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer

Autor: Patrick M. Dillon, Gina R. Petroni, Mark E. Smolkin, David R. Brenin, Kimberly A. Chianese-Bullock, Kelly T. Smith, Walter C. Olson, Ibrahim S. Fanous, Carmel J. Nail, Christiana M. Brenin, Emily H. Hall, Craig L. Slingluff

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-10 (2017)

Abstract Background Breast cancer remains a leading cause of cancer death worldwide. There is evidence that immunotherapy may play a role in the eradication of residual disease. Peptide vaccines for immunotherapy are capable of durable immune memory,

Externí odkaz: https://doaj.org/article/6b7cf945a9c4403e807ea3f6e96728ea

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Akademický článek

The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial

Autor: Donald T. Weed, Serena Zilio, Isildinha M. Reis, Zoukaa Sargi, Marianne Abouyared, Carmen R. Gomez-Fernandez, Francisco J. Civantos, Carla P. Rodriguez, Paolo Serafini

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and recurrence of human malignancies and in restraining the efficacy of adjuvant therapies. We have previously shown that Tadalafil lowers MDSCs and regulatory T cells (Treg)

Externí odkaz: https://doaj.org/article/77b8496b93dd4a6e97bb4902bd76abdf

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Akademický článek

Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial

Autor: Mansi Saxena, Rachel L. Sabado, Melissa La Mar, Hiroshi Mohri, Andres M. Salazar, Hanqing Dong, Joel Correa Da Rosa, Martin Markowitz, Nina Bhardwaj, Elizabeth Miller

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Objective: Toll-like receptor-3 agonist Poly-ICLC has been known to activate immune cells and induce HIV replication in pre-clinical experiments. In this study we investigated if Poly-ICLC could be used for disrupting HIV latency while simultaneously

Externí odkaz: https://doaj.org/article/8882ec04a6a34d43ab8b7793ad5b0f59

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A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy

Autor: Sanne van der Heijden, Zwi N. Berneman, Filip Lardon, An Wouters, Evelien Smits, Jorrit De Waele, Tias Verhezen, Marc Peeters

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-20 (2021)
Journal of Experimental and Clinical Cancer Research
Journal of Experimental & Clinical Cancer Research : CR

Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to develop dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b1cdb004c993eac015a6f23ce4ea20
https://doaj.org/article/4e74d57df4f94a0fbb9a416bc7ae9cce

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