Zobrazeno 1 - 10
of 642
pro vyhledávání: '"Poly (ADP-ribose) polymerase (PARP)"'
Autor:
Jiayi Li, Ziqi Jia, Lin Dong, Heng Cao, Yansong Huang, Hengyi Xu, Zhixuan Xie, Yiwen Jiang, Xiang Wang, Jiaqi Liu
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-32 (2024)
Abstract DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic i
Externí odkaz:
https://doaj.org/article/022406c0024840c49cd64f88da50a85b
Autor:
Elias Obeid, Rohan C. Parikh, Elizabeth Esterberg, Bhakti Arondekar, Abigail Hitchens, Lillian Shahied Arruda, Alexander Niyazov, Kristen Whitaker
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
AimTo examine clinical characteristics, real-world treatment patterns, and health outcomes among patients with germline BRCA1/2-mutated, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer (ABC).MethodsA retrospective an
Externí odkaz:
https://doaj.org/article/87cee8aa415a4c878d1bef57e7b50c16
Akademický článek
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Autor:
Algethami M, Kulkarni S, Sadiq MT, Tang HKC, Brownlie J, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S
Publikováno v:
Cancer Management and Research, Vol Volume 14, Pp 3469-3483 (2022)
Mashael Algethami,1 Sanat Kulkarni,2 Maaz T Sadiq,3 Hiu KC Tang,4 Juliette Brownlie,1 Jennie N Jeyapalan,1 Nigel P Mongan,1 Emad A Rakha,1 Srinivasan Madhusudan1,4 1Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, Univ
Externí odkaz:
https://doaj.org/article/8ed69deddd3147c7843bb982e05d5b93
Autor:
Takao Karasawa, Riko Sato, Tadaatsu Imaizumi, Shun Hashimoto, Masashi Fujita, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Kiminori Terui, Hiroshi Tanaka
Publikováno v:
Renal Failure, Vol 44, Iss 1, Pp 137-145 (2022)
Background Sustained type I interferon (IFN) activation via Toll-like receptor (TLR) 3, 7 and 9 signaling has been reported to play a pivotal role in the development of lupus nephritis (LN). Although type I IFN activation has been shown to induce int
Externí odkaz:
https://doaj.org/article/8be58796b43b485d9d516880d6fab906
Autor:
Aikaterini Tsantikidi, Eirini Papadopoulou, Vasiliki Metaxa-Mariatou, George Kapetsis, Georgios Tsaousis, Angeliki Meintani, Chrysiida Florou-Chatzigiannidou, Maria Gazouli, Christos Papadimitriou, Eleni Timotheadou, Athanasios Kotsakis, Anastasios Boutis, Ioannis Boukovinas, Eleftherios Kampletsas, Loukas Kontovinis, Elena Fountzilas, Charalampos Andreadis, Charisios Karanikiotis, Dimitrios Filippou, Georgios Theodoropoulos, Mustafa Özdoğan, George Nasioulas
Publikováno v:
Diagnostics, Vol 13, Iss 18, p 2962 (2023)
Several tumor types have been efficiently treated with PARP inhibitors (PARPis), which are now approved for the treatment of ovarian, breast, prostate, and pancreatic cancers. The BRCA1/2 genes and mutations in many additional genes involved in the H
Externí odkaz:
https://doaj.org/article/d2ca410e5d3c42a1ae693c3b0eb61e8b
Autor:
Emad Matanes, Vanessa M. López-Ozuna, David Octeau, Tahira Baloch, Florentin Racovitan, Amandeep Kaur Dhillon, Roy Kessous, Oded Raban, Liron Kogan, Shannon Salvador, Susie Lau, Walter H. Gotlieb, Amber Yasmeen
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundPoly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair interruption and consequently induces cell death. This study aims to evaluate the eff
Externí odkaz:
https://doaj.org/article/0d9e891b94894a599e68b3cae7e6c7f2
Autor:
Katarzyna Rygiel
Publikováno v:
European Medical Journal Oncology, Vol 7, Iss 1, Pp 68-76 (2019)
Inhibitors of poly(ADP-ribose) polymerase (PARP), such as olaparib and talazoparib, have recently been approved as therapies for BRCA-mutated human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (BC). In addition, olapari
Externí odkaz:
https://doaj.org/article/7ba1e66b764543718ef568ea47b5e021
Publikováno v:
Regulatory Mechanisms in Biosystems, Vol 10, Iss 4, Pp 513-519 (2019)
The complications of both first and second types of diabetes mellitus patients are important cause of decline in quality of life and mortality worldwide. Diabetic retinopathy (DR) is a widespread complication that affects almost 60% of patients with
Externí odkaz:
https://doaj.org/article/2c130c4a9d664bd788bc73f279c92945
Autor:
Paul Lesueur, Justine Lequesne, Jean-Michel Grellard, Audrey Dugué, Elodie Coquan, Pierre-Emmanuel Brachet, Julien Geffrelot, William Kao, Evelyne Emery, David Hassanein Berro, Laurent Castera, Nicolas Goardon, Joëlle Lacroix, Marie Lange, Aurélie Capel, Alexandra Leconte, Benoit Andre, Angélique Léger, Anaïs Lelaidier, Bénédicte Clarisse, Dinu Stefan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Despite multimodality treatments including neurosurgery, radiotherapy and chemotherapy, glioblastoma (GBM) prognosis remains poor. GBM is classically considered as a radioresistant tumor, because of its high local recurrence rate,
Externí odkaz:
https://doaj.org/article/dee3a7bd8220456fb49a0c557986b2f3