Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.

Autor: Sanmarco LM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Rone JM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Polonio CM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Fernandez Lahore G; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Giovannoni F; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Ferrara K; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Gutierrez-Vazquez C; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Li N; Synlogic Therapeutics, Cambridge, MA, USA., Sokolovska A; Synlogic Therapeutics, Cambridge, MA, USA., Plasencia A; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Faust Akl C; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Nanda P; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Heck ES; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Li Z; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Lee HG; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Chao CC; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Rejano-Gordillo CM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Fonseca-Castro PH; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Illouz T; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Linnerbauer M; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Kenison JE; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Barilla RM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Farrenkopf D; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Stevens NA; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Piester G; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Chung EN; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Dailey L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kuchroo VK; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Hava D; Synlogic Therapeutics, Cambridge, MA, USA., Wheeler MA; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Clish C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nowarski R; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Balsa E; Centro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain., Lora JM; Synlogic Therapeutics, Cambridge, MA, USA., Quintana FJ; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. fquintana@rics.bwh.harvard.edu.

Publikováno v: Nature [Nature] 2023 Aug; Vol. 620 (7975), pp. 881-889. Date of Electronic Publication: 2023 Aug 09.

Identification of astrocyte regulators by nucleic acid cytometry.

Autor: Clark IC; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering, College of Engineering, California Institute for Quantitative Biosciences, QB3, University of California Berkeley, Berkeley, CA, USA., Wheeler MA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee HG; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Li Z; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sanmarco LM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Thaploo S; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Polonio CM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Shin SW; Department of Bioengineering, College of Engineering, California Institute for Quantitative Biosciences, QB3, University of California Berkeley, Berkeley, CA, USA., Scalisi G; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Henry AR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Rone JM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Giovannoni F; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Charabati M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Akl CF; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Aleman DM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zandee SEJ; Neuroimmunology Research Lab, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada., Prat A; Neuroimmunology Research Lab, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada., Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Boritz EA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. fquintana@rics.bwh.harvard.edu., Abate AR; Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA. adam@abatelab.org.

Publikováno v: Nature [Nature] 2023 Feb; Vol. 614 (7947), pp. 326-333. Date of Electronic Publication: 2023 Jan 04.

SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes.

Autor: de Oliveira LG; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil., de Souza Angelo Y; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil., Yamamoto P; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil., Carregari VC; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil., Crunfli F; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil., Reis-de-Oliveira G; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil., Costa L; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil., Vendramini PH; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil., Duque ÉA; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Dos Santos NB; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Firmino EM; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology-Ribeirão Preto Medical School-University of São Paulo, Ribeirão Preto, Brazil., Paiva IM; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology-Ribeirão Preto Medical School-University of São Paulo, Ribeirão Preto, Brazil., Almeida GM; Department of Biocehmistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Sebollela A; Department of Biocehmistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Polonio CM; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil., Zanluqui NG; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil., de Oliveira MG; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil., da Silva P; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil., Davanzo GG; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil., Ayupe MC; Laboratory of Mucosal Immunology, Department of Immunology-Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., Salgado CL; Laboratory of Mucosal Immunology, Department of Immunology-Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., de Souza Filho AF; Laboratory of Applied Research in Mycobacteria, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., de Araújo MV; Laboratory of Applied Research in Mycobacteria, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Silva-Pereira TT; Laboratory of Applied Research in Mycobacteria, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., de Almeida Campos AC; Scientific Platform Pasteur - USP, University of São Paulo, São Paulo, SP, Brazil., Góes LGB; Scientific Platform Pasteur - USP, University of São Paulo, São Paulo, SP, Brazil., Dos Passos Cunha M; Scientific Platform Pasteur - USP, University of São Paulo, São Paulo, SP, Brazil., Caldini EG; Laboratory of Cellular Biology (LIM 59), School of Medicine, University of São Paulo, São Paulo, SP, Brazil., D'Império Lima MR; Department of Immunology, University of São Paulo, São Paulo, SP, Brazil., Fonseca DM; Laboratory of Mucosal Immunology, Department of Immunology-Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., de Sá Guimarães AM; Laboratory of Applied Research in Mycobacteria, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Minoprio PC; Scientific Platform Pasteur - USP, University of São Paulo, São Paulo, SP, Brazil., Munhoz CD; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Mori CMC; Department of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, São Paulo, SP, Brazil., Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil., Cunha TM; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology-Ribeirão Preto Medical School-University of São Paulo, Ribeirão Preto, Brazil., Martins-de-Souza D; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil.; D'Or Institute for Research and Education (IDOR), São Paulo, SP, Brazil.; Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, SP, Brazil., Peron JPS; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, São Paulo, SP, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, SP, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.

Publikováno v: Journal of neurochemistry [J Neurochem] 2022 Oct; Vol. 163 (2), pp. 113-132. Date of Electronic Publication: 2022 Aug 15.

Effect of Rapamycin on MOG-Reactive Immune Cells and Lipopolysaccharide-Activated Microglia: An In Vitro Approach for Screening New Therapies for Multiple Sclerosis.

Autor: Borim PA; Graduate Program in Tropical Diseases, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Mimura LAN; Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil., Zorzella-Pezavento SFG; Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil., Polonio CM; Institute of Biomedical Sciences, University of São Paulo (ICB IV/USP), São Paulo, Brazil., Peron JPS; Institute of Biomedical Sciences, University of São Paulo (ICB IV/USP), São Paulo, Brazil., Sartori A; Graduate Program in Tropical Diseases, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.; Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil., Fraga-Silva TFC; Graduate Program in Tropical Diseases, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.

Publikováno v: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2022 Apr; Vol. 42 (4), pp. 153-160. Date of Electronic Publication: 2022 Apr 06.

ZIKV Infection and miRNA Network in Pathogenesis and Immune Response.

Autor: Polonio CM; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Laboratory of Neuroimmunology of Arboviruses, Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-020, Brazil., Peron JPS; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Laboratory of Neuroimmunology of Arboviruses, Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-020, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo, São Paulo 01246-000, Brazil.

Publikováno v: Viruses [Viruses] 2021 Oct 04; Vol. 13 (10). Date of Electronic Publication: 2021 Oct 04.