Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Pollyanna Goh"'
Autor:
Alexandra Botté, Jeanne Lainé, Laura Xicota, Xavier Heiligenstein, Gaëlle Fontaine, Amal Kasri, Isabelle Rivals, Pollyanna Goh, Orestis Faklaris, Jack-Christophe Cossec, Etienne Morel, Anne-Sophie Rebillat, Dean Nizetic, Graça Raposo, Marie-Claude Potier
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Abstract Enlarged early endosomes have been visualized in Alzheimer’s disease (AD) and Down syndrome (DS) using conventional confocal microscopy at a resolution corresponding to endosomal size (hundreds of nm). In order to overtake the diffraction
Externí odkaz:
https://doaj.org/article/26fd67e10b014d1ab8afbad372ac26f6
Autor:
Andrew M. Davidoff, Taosheng Chen, R. Kiplin Guy, Stephen White, Douglas R. Green, Junmin Peng, Chunxu Qu, Yong Cheng, Ashutosh Mishra, Jie J. Zheng, Zhenmei Li, Yinan Wu, Anang Shelat, Sourav Das, Brandon Young, Vincent A. Boyd, Su Sien Ong, Yingdi Wang, Ruoning Wang, Amit C. Nathwani, Pollyanna Goh, Ju Bao, Wenwei Lin, Jonathan Low, Jesse Davidson, Junfang Zhou, Rodrigo B. Interiano, Alaa M. AlTahan, Dongli Hu, Sandra Milasta, Jun Yang
Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone demethylases influence the viability and poor prognosis of neuroblastoma cells, where MYC is often over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e96065cdcf2a58b228dbe3422f2dd09
https://doi.org/10.1158/0008-5472.c.6508916
https://doi.org/10.1158/0008-5472.c.6508916
Autor:
Andrew M. Davidoff, Taosheng Chen, R. Kiplin Guy, Stephen White, Douglas R. Green, Junmin Peng, Chunxu Qu, Yong Cheng, Ashutosh Mishra, Jie J. Zheng, Zhenmei Li, Yinan Wu, Anang Shelat, Sourav Das, Brandon Young, Vincent A. Boyd, Su Sien Ong, Yingdi Wang, Ruoning Wang, Amit C. Nathwani, Pollyanna Goh, Ju Bao, Wenwei Lin, Jonathan Low, Jesse Davidson, Junfang Zhou, Rodrigo B. Interiano, Alaa M. AlTahan, Dongli Hu, Sandra Milasta, Jun Yang
Figure S1 shows siRNA screening in neuroblastoma cells. Figure S2 shows the dentification of ciclopirox that targets KDM4B. Figure S3 shows the CPX effect on other histone methyl marks. Figure S4 shows that CPX targets the Myc pathway. Figure S5 show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c093311ea8c98a81adeb8b227cbaf3d
https://doi.org/10.1158/0008-5472.22414205
https://doi.org/10.1158/0008-5472.22414205
Autor:
Pollyanna Goh, Regina Trollmann, Marielle Minere, Saad Hannan, Bernt Popp, Charlotte J. Maughan Jones, Aida Helana Binti Affandi, Trevor G. Smart, Dean Nizetic, Gary Warnes
Publikováno v:
The Journal of Neuroscience. 40:5518-5530
GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature prominently in excitability disorders and neurodevelopmental deficits following disruption to GABA
Publikováno v:
International Journal of Stem Cells
Mbd3 (Methyl-CpG binding domain protein), a core member of NuRD (nucleosome remodelling and deacetylation) is essential for embryogenesis. However, its role in reprogramming of somatic cells into induced pluripotent stem cells (iPSC) remains controve
Autor:
Jia Nee Foo, Andre Strydom, Xiaowei Shao, David Koschut, Goran Šimić, Željka Krsnik, Sarah Hamburg, Ivan Alić, Steven Havlicek, Hlin Kvartsberg, Jürgen Groet, Paul T. Francis, Yee Jie Yeap, Pollyanna Goh, Hilkka Soininen, Rosalyn Hithersay, John Hardy, Niamh L. O'Brien, Margaret Phillips, David Laurence Becker, N. Ray Dunn, Gunnar Brinkmalm, David Wallon, Gillian Gough, Henrik Zetterberg, Erik Portelius, Mark Turmaine, Aoife Murray, Jorge Ghiso, Kaj Blennow, Eleni Gkanatsiou, Agueda Rostagno, Carla M. Startin, Ivica Kostović, Konstantin Pervushin, Emanuela V. Volpi, Dean Nižetić, Joanne E. Martin, Dinko Mitrečić, Reinhard Brunmeir, Kin Y. Mok, Anne Rovelet-Lecrux
Publikováno v:
Molecular Psychiatry
A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09de58af74b7f90b471059b4fee6daab
https://doi.org/10.1038/s41380-020-0806-5
https://doi.org/10.1038/s41380-020-0806-5
Autor:
John Hardy, Aoife Murray, David Wallon, Dean Nizetic, Agueda Rostagno, Ivan Alić, Pollyanna Goh, Gillian Gough, Jorge Ghiso, Andre Strydom, Henrik Zetterberg, Erik Portelius, Eleni Gkanatsiou, Anne Rovelet-Lecrux, Paul T. Francis
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Jorge Ghiso, Agueda Rostagno, Steven Havlicek, Sarah Hamburg, Ivan Alić, Carla M. Startin, Rosalyn Hithersay, Eleni Gkanatsiou, David Koschut, Hlin Kvartsberg, Hilkka Soininen, Emanuela V. Volpi, Xiaowei Shao, Goran Šimić, Željka Krsnik, Dean Nižetić, Mark Turmaine, Joanne E. Martin, Jürgen Groet, Aoife Murray, Erik Portelius, Pollyanna Goh, Jia Nee Foo, Niamh L. O'Brien, Henrik Zetterberg, Andre Strydom, Yee Jie Yeap, David Wallon, Gillian Gough, John Hardy, Margaret Phillips, N. Ray Dunn, Dinko Mitrečić, Gunnar Brinkmalm, Reinhard Brunmeir, Kin Y. Mok, Anne Rovelet-Lecrux, Kaj Blennow, Ivica Kostović, Konstantin Pervushin, Paul T. Francis, David Laurence Becker
A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111391dc58615029c3c88bcbe66e06ec
Autor:
Niamh L. O'Brien, Jürgen Groet, Pollyanna Goh, Gillian Gough, Aoife Murray, Ivan Alić, Yee Jie Yeap, Dean Nizetic
Down Syndrome (DS) is a complex chromosomal disorder, with neurological issues, featuring among the symptoms. Primary neuronal cells and tissues are extremely useful, but limited both in supply and experimental manipulability. To better understand th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14b1690104b1e7420aceec76fc22e66
https://doi.org/10.1016/bs.pbr.2019.10.003
https://doi.org/10.1016/bs.pbr.2019.10.003
Autor:
Botté, Alexandra, Lainé, Jeanne, Xicota, Laura, Heiligenstein, Xavier, Fontaine, Gaëlle, Kasri, Amal, Rivals, Isabelle, Pollyanna Goh, Orestis Faklaris, Jack-Christophe Cossec, Morel, Etienne, Anne-Sophie Rebillat, Nizetic, Dean, Raposo, Graça, Potier, Marie-Claude
Additional file 2: Supplementary Table. Demographic description of fibroblasts from euploid individuals and individuals with DS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06defddba7ec30cccf25346c4884169b