Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: Results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study

Autor: Chanchlani, N, Lin, S, Auth, MK, Lee, CL, Robbins, H, Looi, S, Murugesan, SV, Riley, T, Preston, C, Stephenson, S, Cardozo, W, Sonwalkar, SA, Allah-Ditta, M, Mansfield, L, Durai, D, Baker, M, London, I, London, E, Gupta, S, Di Mambro, A, Murphy, A, Gaynor, E, Jones, KDJ, Claridge, A, Sebastian, S, Ramachandran, S, Selinger, CP, Borg-Bartolo, SP, Knight, P, Sprakes, MB, Burton, J, Kane, P, Lupton, S, Fletcher, A, Gaya, DR, Colbert, R, Seenan, JP, MacDonald, J, Lynch, L, McLachlan, I, Shields, S, Hansen, R, Gervais, L, Jere, M, Akhtar, M, Black, K, Henderson, P, Russell, RK, Lees, CW, Derikx, LAAP, Lockett, M, Betteridge, F, De Silva, A, Hussenbux, A, Beckly, J, Bendall, O, Hart, JW, Thomas, A, Hamilton, B, Gordon, C, Chee, D, McDonald, TJ, Nice, R, Parkinson, M, Gardner-Thorpe, H, Butterworth, JR, Javed, A, Al-Shakhshir, S, Yadagiri, R, Maher, S, Pollok, RCG, Ng, T, Appiahene, P, Donovan, F, Lok, J, Chandy, R, Jagdish, R, Baig, D, Mahmood, Z, Marsh, L, Moss, A, Abdulgader, A, Kitchin, A, Walker, GJ, George, B, Lim, Y-H, Gulliver, J, Bloom, S, Theaker, H, Carlson, S, Cummings, JRF, Livingstone, R, Beale, A, Carter, JO, Bell, A, Coulter, A, Snook, J, Stone, H, Kennedy, NA, Goodhand, JR, Ahmad, T, IMSAT study investigators

BACKGROUND: Anti-drug antibodies are associated with treatment failure to anti-TNF agents in patients with inflammatory bowel disease (IBD). AIM: To assess whether immunogenicity to a patient's first anti-TNF agent would be associated with immunogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::39d735bb09a4a7716e305b56c8e08c0b

Stoma formation in Crohn's Disease and the likelihood of antidepressant use: a population-based cohort study

Autor: Blackwell, J, Saxena, S, Jayasooriya, N, Petersen, I, Hotopf, M, Creese, H, Bottle, A, Pollok, RCG, POP-IBD study group

BACKGROUND AND AIMS: The impact of a temporary or permanent stoma on mental health in Crohn's Disease (CD) is unknown. AIM: To examine the association between intestinal surgery and stoma formation and subsequent antidepressant medication (ADM) use.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::8ec3d62f958d31da320af444c2bb56fc

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

Autor: Walker, GJ, Harrison, JW, Heap, GA, Voskuil, MD, Andersen, V, Anderson, CA, Ananthakrishnan, AN, Barrett, JC, Beaugerie, L, Bewshea, CM, Cole, AT, Cummings, FR, Daly, MJ, Ellul, P, Fedorak, RN, Festen, EAM, Florin, TH, Gaya, DR, Halfvarson, J, Hart, AL, Heerasing, NM, Hendy, P, Irving, PM, Jones, SE, Koskela, J, Lindsay, JO, Mansfield, JC, McGovern, D, Parkes, M, Pollok, RCG, Ramakrishnan, S, Rampton, DS, Rivas, MA, Russell, RK, Schultz, M, Sebastian, S, Seksik, P, Singh, A, So, K, Sokol, H, Subramaniam, K, Todd, A, Annese, V, Weersma, RK, Xavier, R, Ward, R, Weedon, MN, Goodhand, JR, Kennedy, NA, Ahmad, T, Holden, AL, Andrews, J, Auth, M, Babu, S, Bampton, P, Banim, P, Barnes, T, Basude, D, Beckly, J, Bell, A, Bell, S, Bhandari, P, Bloom, S, Border, D, Bredin, F, Brookes, MJ, Brown, M, Calvert, C, Campbell, D, Chanchlani, N, Chaudhary, B, Chaudhary, R, Chung-Faye, G, Colleypriest, B, Connor, S, Cooney, R, Cooper, S, Creed, TJ, Croft, N, Cullen, S, D'Amato, M, Dalal, H, Daneshmend, TK, Das, D, Delaney, M, Desilva, S, Dhar, A, Dharmasiri, S, Direkze, N, Dunckley, P, Elphick, D, Everett, SM, Feeney, M, Fell, J, Foley, S, Franke, A, Gavin, D, Gee, I, Ghosh, D, Goldsmith, C, Gorard, D, Gordon, JN, Gore, S, Green, J, Grimes, D, Hamill, G, Harbord, M, Hart, J, Hawkey, C, Iqbal, T, Ireland, A, Johnson, M, Jones, C, Kanegasundaram, S, Karban, A, Katsanos, KH, Kiparissi, F, Kirkham, S, Lal, S, Langlands, S, Lawrance, IC, Lees, CW, Lev-Tzion, R, Levison, S, Lewis, SJ, Li, A, Limdi, J, Lin, S, Lobo, A, Lockett, M, Loehry, J, MacDonald, C, MacFaul, G, Mahmood, T, Mann, S, Mawdsley, J, Mazhar, Z, McGovern, JF, McNair, A, Modi, A, Monahan, K, Moran, A, Morris, M-A, Mortimore, M, Mowat, C, Muhammed, R, Murray, CDR, Olivier, H, Orchard, TR, Panter, S, Patel, V, Phillips, R, Prasad, N, Preston, C, Radford-Smith, G, Rajasekhar, P, Roy, D, Saich, R, Satsangi, J, Schreiber, S, Sen, S, Shah, N, Shenderay, R, Shenoy, A, Shutt, J, Silverberg, M, Simmons, A, Simmons, J, Singh, S, Smith, M, Snook, JA, Sonwalker, S, Stevens, CR, Sturniolo, G, Subramanian, S, Thomas, A, Tighe, M, Torrente, F, Tremelling, M, Tsianos, E, Vani, D, Walsh, A, Watermeyer, G, Watts, D, Watts, G, Weaver, S, Wesley, E, Willmott, A, Yearsley, K, Zambar, V, Zeissig, S

Publikováno v: JAMA, 321(8), 773-785. AMER MEDICAL ASSOC

Funding Information: reported serving as a consultant for AbbVie UK; receiving honoraria from Falk and AbbVie UK; receiving grants from Crohn’s & Colitis UK and Tillott’s Pharmaceuticals; having a fellowship from the UK National Institute for Hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8d78d1552e80b56aa35df97ff0b107
http://hdl.handle.net/10138/308428

Diagnostic imaging and radiation exposure in inflammatory bowel disease

Autor: Zakeri, N, Pollok, RCG

Diagnostic imaging plays a key role in the diagnosis and management of inflammatory bowel disease (IBD). However due to the relapsing nature of IBD, there is growing concern that IBD patients may be exposed to potentially harmful cumulative levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3a922198c6b364d0f84f43d176d3166c

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