Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Pollock KM"'
Autor:
Writing Committee for the REMAP-CAP Investigators, Lawler, PR, Derde, LPG, Van de Veerdonk, FL, McVerry, BJ, Huang, DT, Berry, LR, Lorenzi, E, Van Kimmenade, R, Gommans, F, Vaduganathan, M, Leaf, DE, Baron, RM, Kim, EY, Frankfurter, C, Epelman, S, Kwan, Y, Grieve, R, O'Neill, S, Sadique, Z, Puskarich, M, Marshall, JC, Higgins, AM, Mouncey, PR, Rowan, KM, Al-Beidh, F, Annane, D, Arabi, YM, Au, C, Beane, A, Van Bentum-Puijk, W, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Burrell, A, Buzgau, A, Buxton, M, Cecconi, M, Cheng, AC, Cove, M, Detry, MA, Estcourt, LJ, Ezekowitz, J, Fitzgerald, M, Gattas, D, Godoy, LC, Goossens, H, Haniffa, R, Harrison, DA, Hills, T, Horvat, CM, Ichihara, N, Lamontagne, F, Linstrum, KM, McAuley, DF, McGlothlin, A, McGuinness, SP, McQuilten, Z, Murthy, S, Nichol, AD, Owen, DRJ, Parke, RL, Parker, JC, Pollock, KM, Reyes, LF, Saito, H, Santos, MS, Saunders, CT, Seymour, CW, Shankar-Hari, M, Singh, V, Turgeon, AF, Turner, AM, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, Berry, S, Gordon, AC, McArthur, CJ, Webb, SA
IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. OBJECTIVE: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::063b737fa1cd9108ed66af2f4c2faae0
http://hdl.handle.net/10044/1/104002
http://hdl.handle.net/10044/1/104002
Autor:
Robbins, AJ, Che Bakri, NA, Toke-Bjolgerud, E, Edwards, A, Vikraman, A, Michalsky, C, Fossler, M, Lemm, N-M, Medhipour, S, Budd, W, Gravani, A, Hurley, L, Kapil, V, Jackson, A, Lonsdale, D, Latham, V, Laffan, M, Chapman, N, Cooper, N, Szydlo, R, Boyle, J, Pollock, KM, Owen, D
COVID-19 causes significant thrombosis and coagulopathy, with elevated D-dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear, one hypothesis is that loss of Angiotensin Converting Enzyme 2 activity during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::3e3d7b622de10bd9668381a94fcf724b
http://hdl.handle.net/10044/1/100559
http://hdl.handle.net/10044/1/100559
Autor:
Liu, Z, Le, K, Zhou, X, Alexander, J, Lin, S, Bewshea, C, Chanchlani, N, Nice, R, McDonald, T, Lamb, C, Sebastian, S, Kok, K, Lees, C, Hart, A, Pollok, R, Boyton, R, Altmann, DM, Pollock, KM, Goodhand, J, Kennedy, N, Ahmad, T, Powell, N
Background: Anti-tumour necrosis factor (TNF) drugs such as infliximab are associated with attenuated antibody responses after COVID-19 vaccination. It is unknown how infliximab impacts vaccine-induced serological responses against highly transmissib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::be8005ae711ecf2c0960167252029a8a
http://hdl.handle.net/10044/1/100318
http://hdl.handle.net/10044/1/100318
Autor:
Fidler, S, Fox, J, Tipoe, T, Longet, S, Tipton, T, Abeywickrema, M, Adele, S, Alagaratnam, J, Ali, M, Aley, PK, Aslam, S, Balasubramanian, A, Bara, A, Bawa, T, Brown, A, Brown, H, Cappuccini, F, Davies, S, Fowler, J, Godfrey, L, Goodman, AL, Hilario, K, Hackstein, CP, Mathew, M, Mujadidi, YF, Packham, A, Petersen, C, Plested, E, Pollock, KM, Ramasamy, MN, Robinson, H, Robinson, N, Rongkard, P, Sanders, H, Serafimova, T, Spence, N, Waters, A, Woods, D, Zacharopoulou, P, Barnes, E, Dunachie, S, Goulder, P, Klenerman, P, Winston, A, Hill, AVS, Gilbert, SC, Carroll, M, Pollard, AJ, Lambe, T, Ogbe, A, Frater, J
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
BACKGROUND: People with HIV on antiretroviral therapy with good CD4 T cell counts make effective immune responses following vaccination against SARS-CoV-2. There are few data on longer term responses and the impact of a booster dose. METHODS: Adults
Autor:
Szubert, AJ, Pollock, KM, Cheeseman, HM, Alagaratnam, J, Bern, H, Bird, O, Boffito, M, Byrne, R, Cole, T, Cosgrove, CA, Faust, SN, Fidler, S, Galiza, E, Hassanin, H, Kalyan, M, Libri, V, McFarlane, LR, Milinkovic, A, O'Hara, J, Owen, DR, Owens, D, Pacurar, M, Rampling, T, Skene, S, Winston, A, Woolley, J, Yim, YTN, Dunn, DT, McCormack, S, Shattock, RJ, COVAC 1 Study Team
Publikováno v:
eClinicalMedicine. 56:101823
Background: lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative and seropositive individuals aged 18–75. Methods: a phase 2a expanded safety and immunogenicity study of a sa
Autor:
Feng, S, Phillips, DJ, White, T, Sayal, H, Aley, PK, Bibi, S, Dold, C, Fuskova, M, Gilbert, SC, Hirsch, I, Humphries, HE, Jepson, B, Kelly, EJ, Plested, E, Shoemaker, K, Thomas, KM, Vekemans, J, Villafana, TL, Lambe, T, Pollard, AJ, Voysey, M, Adlou, S, Allen, L, Angus, B, Anslow, R, Asselin, M-C, Baker, N, Baker, P, Barlow, T, Beveridge, A, Bewley, KR, Brown, P, Brunt, E, Buttigieg, KR, Camara, S, Charlton, S, Chiplin, E, Cicconi, P, Clutterbuck, EA, Collins, AM, Coombes, NS, Clemens, SAC, Davison, M, Demissie, T, Dinesh, T, Douglas, AD, Duncan, CJA, Emary, KRW, Ewer, KJ, Felle, S, Ferreira, DM, Finn, A, Folegatti, PM, Fothergill, R, Fraser, S, Garlant, H, Gatcombe, L, Godwin, KJ, Goodman, AL, Green, CA, Hallis, B, Hart, TC, Heath, PT, Hill, H, Hill, AVS, Jenkin, D, Kasanyinga, M, Kerridge, S, Knight, C, Leung, S, Libri, V, Lillie, PJ, Marinou, S, McGlashan, J, McGregor, AC, McInroy, L, Minassian, AM, Mujadidi, YF, Penn, EJ, Petropoulos, CJ, Pollock, KM, Proud, PC, Provstgaard-Morys, S, Rajapaska, D, Ramasamy, MN, Sanders, K, Shaik, I, Singh, N, Smith, A, Snape, MD, Song, R, Shrestha, S, Sutherland, RK, Thomson, EC, Turner, DPJ, Webb-Bridges, A, Wrin, T, Williams, CJ
Publikováno v:
Nature Medicine
The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data from a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222)
Antiretroviral therapy (ART) has improved survival into adulthood for young people with perinatally acquired HIV-1 (yp-PaHIV), but long-term prognosis remains unclear. We hypothesized that on-going immune activation, re fl ected in the failure of CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::5e6a214cd7fa3c4f0e2dc83621bccea5
http://hdl.handle.net/10044/1/56451
http://hdl.handle.net/10044/1/56451
Publikováno v:
HIV Medicine; Feb2020, Vol. 21 Issue 2, p109-118, 10p
Autor:
Pollock, KM, Montamat-Sicotte, DJ, Cooke, GS, Kapembwa, MS, Kon, OM, Grass, L, Sampson, RD, Taylor, GP, Lalvani, A
HIV-infected individuals with severe immunodeficiency are at risk of opportunistic infection (OI). Tuberculosis (TB) may occur without substantial immune suppression suggesting an early and sustained adverse impact of HIV on Mycobacterium tuberculosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::0320607b23f7053044999aa9405cec14
http://hdl.handle.net/10044/1/41030
http://hdl.handle.net/10044/1/41030
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