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Single-cell transcriptional landscapes reveal HIV-1-driven aberrant host gene transcription as a potential therapeutic target.

Autor: Liu R; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA., Yeh YJ; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA., Varabyou A; Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Collora JA; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA., Sherrill-Mix S; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Talbot CC Jr; Institute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Mehta S; Yale Center for Genome Analysis, Yale University, New Haven, CT 06519, USA., Albrecht K; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA., Hao H; Institute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Zhang H; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA., Pollack RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Beg SA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Calvi RM; Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA., Hu J; Vaccine Research Center, National Institute of Health, Bethesda, MD 20892, USA., Durand CM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Ambinder RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Hoh R; Department of Medicine, University of California, San Francisco, CA 94110, USA., Deeks SG; Department of Medicine, University of California, San Francisco, CA 94110, USA., Chiarella J; Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA., Spudich S; Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA., Douek DC; Vaccine Research Center, National Institute of Health, Bethesda, MD 20892, USA., Bushman FD; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Pertea M; Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Ho YC; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. ya-chi.ho@yale.edu.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 May 13; Vol. 12 (543).

Bystander automated external defibrillator application in non-shockable out-of-hospital cardiac arrest.

Autor: Pollack RA; Johns Hopkins University School of Medicine, 1812 Ashland Ave. Suite 110, Baltimore, MD 21205, United States. Electronic address: rpollac5@jhmi.edu., Brown SP; University of Washington School of Public Health, 6200 NE 74th St., Building 29, Suite 250, Seattle, WA 98115, United States. Electronic address: spes@uw.edu., May S; University of Washington School of Public Health, 6200 NE 74th St., Building 29, Suite 250, Seattle, WA 98115, United States. Electronic address: sjmay@uw.edu., Rea T; University of Washington School of Medicine, 325 Ninth Ave., Seattle, WA 98104, United States. Electronic address: rea123@u.washington.edu., Kudenchuk PJ; University of Washington School of Medicine, 1959 NE Pacific St., 3rd Floor, Seattle, WA 98195, United States. Electronic address: kudenchu@u.washington.edu., Weisfeldt ML; Johns Hopkins University School of Medicine, 1812 Ashland Ave. Suite 110, Baltimore, MD 21205, United States. Electronic address: mlw5@jhmi.edu.

Publikováno v: Resuscitation [Resuscitation] 2019 Apr; Vol. 137, pp. 168-174. Date of Electronic Publication: 2019 Feb 18.

Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests.

Autor: Pollack RA; Johns Hopkins University School of Medicine, Baltimore, MD (R.A.P., M.W.)., Brown SP; Department of Biostatistics (S.P.B.)., Rea T; University of Washington, Seattle (T.R., P.K.).; King County Emergency Medical Services, Public Health, Seattle, WA (T.R., P.K.)., Aufderheide T; Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee (T.A., J.J.)., Barbic D; Department of Emergency Medicine, University of British Columbia, Vancouver, Canada (D.B., J.C.)., Buick JE; Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Canada (J.E.B, L.M.)., Christenson J; Department of Emergency Medicine, University of British Columbia, Vancouver, Canada (D.B., J.C.)., Idris AH; Departments of Emergency Medicine and Internal Medicine, University of Texas Southwestern Medical Center, Dallas (A.H.I.)., Jasti J; Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee (T.A., J.J.)., Kampp M; Department of Emergency Medicine, Oregon Health and Science University, Portland (M.K.)., Kudenchuk P; University of Washington, Seattle (T.R., P.K.).; King County Emergency Medical Services, Public Health, Seattle, WA (T.R., P.K.)., May S; Johns Hopkins University School of Medicine, Baltimore, MD (R.A.P., M.W.)., Muhr M; Clark County Emergency Medical Services, Vancouver, WA (M.M.)., Nichol G; University of Washington-Harborview Center for Prehospital Emergency Care, Seattle (G.N.)., Ornato JP; Department of Emergency Medicine, Virginia Commonwealth University, Richmond (J.P.O.)., Sopko G; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (G.S.)., Vaillancourt C; Department of Emergency Medicine, Ottawa Hospital Research Institute, University of Ottawa, Canada (C.V.)., Morrison L; Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Canada (J.E.B, L.M.).; Division of Emergency Medicine, Department of Medicine, University of Toronto, Ottawa, Canada (L.M.)., Weisfeldt M; Johns Hopkins University School of Medicine, Baltimore, MD (R.A.P., M.W.) mlw5@jhmi.edu.

Publikováno v: Circulation [Circulation] 2018 May 15; Vol. 137 (20), pp. 2104-2113. Date of Electronic Publication: 2018 Feb 26.

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.

Autor: Pollack RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Jones RB; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Pertea M; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Bruner KM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Martin AR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Thomas AS; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Capoferri AA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA., Beg SA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA., Huang SH; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Karandish S; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Hao H; Deep Sequencing & Microarray Core, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Halper-Stromberg E; University of Colorado, Aurora, CO 80045, USA., Yong PC; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Kovacs C; Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Maple Leaf Medical Clinic, Toronto, ON M5G 1K2, Canada., Benko E; Maple Leaf Medical Clinic, Toronto, ON M5G 1K2, Canada., Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA., Ho YC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: yho10@jhmi.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2017 Apr 12; Vol. 21 (4), pp. 494-506.e4.