Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Polla Magnus"'
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 April 2014 22(7):2261-2268
Autor:
Elena Reckzeh, Dennis Schade, Marc N. Hirt, Polla Magnus, Tessa Werner, Fabian Wesseler, Thomas Eschenhagen, Daniel Längle, Lauren Drowley, Niklas Schaumann, Alleyn T. Plowright
Publikováno v:
ChemMedChem. 14:810-822
Innovative therapeutic modalities for pharmacological intervention of transforming growth factor β (TGFβ)-dependent diseases are of great value. b-Annelated 1,4-dihydropyridines (DHPs) might be such a class, as they induce TGFβ receptor type II de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818170e16bcc4f69a400db4b65496d4c
https://doi.org/10.1002/cmdc.201900036
https://doi.org/10.1002/cmdc.201900036
Autor:
Polla, Magnus O., Tottie, Louise, Nordén, Carita, Linschoten, Marcel, Müsil, Djordje, Trumpp-Kallmeyer, Susanne, Aukrust, Inger R., Ringom, Rune, Holm, Kjetil H., Neset, Siren M., Sandberg, Marcel, Thurmond, John, Yu, Peng, Hategan, Georgeta, Anderson, Herb
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 March 2004 12(5):1151-1175
Autor:
C. Wern, Y. Örtengren, M. Strimfors, Ulf Eriksson, S. Nielsen, A.-C. Egnell, Ulf Bredberg, Joakim Bergman, T. Skjaeret, S. Pehrsson, Jonas Brånalt, K.-J. Hoffman, K. Abrahamsson, Ingemar Nilsson, Maria Ölwegård-Halvarsson, Polla Magnus, David Gustafsson, P. Andersson
Publikováno v:
MedChemComm. 7:272-281
A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions. This work resulted in the identification of the highly potent thrombin inhibitor compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d88096e0917304c2cecfe1fa4717862b
https://doi.org/10.1039/c5md00479a
https://doi.org/10.1039/c5md00479a
Autor:
Lisbeth Kristensson, Maria Sörhede Winzell, Sam D. Groombridge, Piotr Raubo, Andrea Ahnmark, William McCoull, Monika Sundqvist, Susanna Myhre, Polla Magnus, Ann-Christin Nyström, Linda Sundström, Mats Någård
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189060 (2017)
PLoS ONE
PLoS ONE
The mechanism behind the glucose lowering effect occurring after specific activation of GPR120 is not completely understood. In this study, a potent and selective GPR120 agonist was developed and its pharmacological properties were compared with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d403700840ffcd7ea5ecb0444d62da4b
http://europepmc.org/articles/PMC5716539?pdf=render
http://europepmc.org/articles/PMC5716539?pdf=render
Autor:
Elise J. Needham, Maryam Clausen, Benjamin L. Parker, Alleyn T. Plowright, Henrik Andersson, Aurélie Bornot, Mei Ding, Gregory A. Quaife-Ryan, Polla Magnus, Richard J. Mills, Qing-Dong Wang, James E. Hudson, Enzo R. Porrello, Lauren Drowley, Holly K. Voges, David E. James, Ian P. Barrett, David A. Elliott
Publikováno v:
Cell Stem Cell. 24:895-907.e6
We have previously developed a high-throughput bioengineered human cardiac organoid (hCO) platform, which provides functional contractile tissue with biological properties similar to native heart tissue, including mature, cell-cycle-arrested cardiomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884879c4b8dc8ea4cd246ae2f996c1c8
https://doi.org/10.1016/j.stem.2019.03.009
https://doi.org/10.1016/j.stem.2019.03.009
Autor:
Polla Magnus, Lauren Drowley, Alleyn T. Plowright, Daniel Längle, Marc N. Hirt, Dennis Schade, Niklas Schaumann, Elena Reckzeh, Fabian Wesseler, Tessa Werner, Thomas Eschenhagen
Publikováno v:
ChemMedChem. 14:796-796
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3051c332c381ac34e413f4628e35c70
https://doi.org/10.1002/cmdc.201900212
https://doi.org/10.1002/cmdc.201900212
Autor:
Nilsson, Ingemar1 Ingemar.nilsson@astrazeneca.com, Polla, Magnus1 Magnus.polla@astrazeneca.com
Publikováno v:
Journal of Computer-Aided Molecular Design. Oct2012, Vol. 26 Issue 10, p1143-1157. 15p. 1 Color Photograph, 2 Diagrams, 3 Charts, 8 Graphs.
Autor:
Jan Kihlberg, Staffan Karlsson, Joakim Bergman, Polla Magnus, Vincent Andersson, Gunnar Grönberg, David Gustafsson, Jonas Brånalt, Fredrik Bergström
Publikováno v:
Journal of medicinal chemistry. 59(14)
The only oral direct thrombin inhibitors that have reached the market, ximelagatran and dabigatran etexilat, are double prodrugs with low bioavailability in humans. We have evaluated an alternative strategy: the preparation of a nonpeptidic, polar di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47650fd9a39eed267f9066c335bf301
https://pubmed.ncbi.nlm.nih.gov/27347787
https://pubmed.ncbi.nlm.nih.gov/27347787
Autor:
Längle, Daniel, Werner, Tessa R., Wesseler, Fabian, Reckzeh, Elena, Schaumann, Niklas, Drowley, Lauren, Polla, Magnus, Plowright, Alleyn T., Hirt, Marc N., Eschenhagen, Thomas, Schade, Dennis
Publikováno v:
ChemMedChem; 4/17/2019, Vol. 14 Issue 8, p810-822, 13p