Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Polla, Magnus"'
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Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors
Autor: Elena Reckzeh, Dennis Schade, Marc N. Hirt, Polla Magnus, Tessa Werner, Fabian Wesseler, Thomas Eschenhagen, Daniel Längle, Lauren Drowley, Niklas Schaumann, Alleyn T. Plowright
Publikováno v: ChemMedChem. 14:810-822
Innovative therapeutic modalities for pharmacological intervention of transforming growth factor β (TGFβ)-dependent diseases are of great value. b-Annelated 1,4-dihydropyridines (DHPs) might be such a class, as they induce TGFβ receptor type II de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818170e16bcc4f69a400db4b65496d4c
https://doi.org/10.1002/cmdc.201900036
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4
Discovery of AZD8165 – a clinical candidate from a novel series of neutral thrombin inhibitors
Autor: C. Wern, Y. Örtengren, M. Strimfors, Ulf Eriksson, S. Nielsen, A.-C. Egnell, Ulf Bredberg, Joakim Bergman, T. Skjaeret, S. Pehrsson, Jonas Brånalt, K.-J. Hoffman, K. Abrahamsson, Ingemar Nilsson, Maria Ölwegård-Halvarsson, Polla Magnus, David Gustafsson, P. Andersson
Publikováno v: MedChemComm. 7:272-281
A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions. This work resulted in the identification of the highly potent thrombin inhibitor compou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d88096e0917304c2cecfe1fa4717862b
https://doi.org/10.1039/c5md00479a
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5
Akademický článek
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6
Akademický článek
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7
The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1
Autor: Lisbeth Kristensson, Maria Sörhede Winzell, Sam D. Groombridge, Piotr Raubo, Andrea Ahnmark, William McCoull, Monika Sundqvist, Susanna Myhre, Polla Magnus, Ann-Christin Nyström, Linda Sundström, Mats Någård
Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0189060 (2017)
PLoS ONE
The mechanism behind the glucose lowering effect occurring after specific activation of GPR120 is not completely understood. In this study, a potent and selective GPR120 agonist was developed and its pharmacological properties were compared with the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d403700840ffcd7ea5ecb0444d62da4b
http://europepmc.org/articles/PMC5716539?pdf=render
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8
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway
Autor: Elise J. Needham, Maryam Clausen, Benjamin L. Parker, Alleyn T. Plowright, Henrik Andersson, Aurélie Bornot, Mei Ding, Gregory A. Quaife-Ryan, Polla Magnus, Richard J. Mills, Qing-Dong Wang, James E. Hudson, Enzo R. Porrello, Lauren Drowley, Holly K. Voges, David E. James, Ian P. Barrett, David A. Elliott
Publikováno v: Cell Stem Cell. 24:895-907.e6
We have previously developed a high-throughput bioengineered human cardiac organoid (hCO) platform, which provides functional contractile tissue with biological properties similar to native heart tissue, including mature, cell-cycle-arrested cardiomy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884879c4b8dc8ea4cd246ae2f996c1c8
https://doi.org/10.1016/j.stem.2019.03.009
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10
Akademický článek
Composite multi-parameter ranking of real and virtual compounds for design of MC4R agonists: Renaissance of the Free-Wilson methodology.
Autor: Nilsson, Ingemar1 Ingemar.nilsson@astrazeneca.com, Polla, Magnus1 Magnus.polla@astrazeneca.com
Publikováno v: Journal of Computer-Aided Molecular Design. Oct2012, Vol. 26 Issue 10, p1143-1157. 15p. 1 Color Photograph, 2 Diagrams, 3 Charts, 8 Graphs.
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