Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Polizzi KM"'
Autor:
Shmool, TA, Martin, LK, Bui-Le, L, Moya-Ramirez, I, Kotidis, P, Matthews, RP, Venter, GA, Kontoravdi, C, Polizzi, KM, Hallett, JP
Publikováno v:
Chemical Science
Understanding protein folding in different environmental conditions is fundamentally important for predicting protein structures and developing innovative antibody formulations. While the thermodynamics and kinetics of folding and unfolding have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7185aa8643dad6a9bea1cfa5cce39801
https://doi.org/10.1039/d1sc02520a
https://doi.org/10.1039/d1sc02520a
Autor:
Aw, R, De Wachter, C, Laukens, B, De Rycke, R, De Bruyne, M, Bell, D, Callewaert, N, Polizzi, KM
The structural organization of the Golgi stacks in mammalian cells is intrinsically linked to function, including glycosylation, but the role of morphology is less clear in lower eukaryotes. Here we investigated the link between the structural organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::cd6f51d73e14c6567d9dce896872a77b
http://hdl.handle.net/10044/1/85103
http://hdl.handle.net/10044/1/85103
Transient gene expression (TGE) is a methodology employed in bioprocessing for the fast provision of recombinant protein material. Mild hypothermia is often introduced to overcome the low yield typically achieved with TGE and improve specific protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::63db753d8333b54cd5f7b49c48a4a64d
http://hdl.handle.net/10044/1/50815
http://hdl.handle.net/10044/1/50815
The use of the recombinant expression platform Pichia pastoris to produce pharmaceutically important proteins has been investigated over the past 30 years. Compared to mammalian cultures, expression in P. pastoris is cheaper and faster, potentially l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::ff5f42dcc7324d05214e44c86ed4f540
http://hdl.handle.net/10044/1/45699
http://hdl.handle.net/10044/1/45699
Biologics are a promising new class of drugs based on complex macromolecules such as proteins and nucleic acids. However, delivery of these macromolecules into the cytoplasm of target cells remains a significant challenge. Here we present one potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::2569047383e65f31399c4c92afa1ad24
http://hdl.handle.net/10044/1/45042
http://hdl.handle.net/10044/1/45042
Many high-value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimise the productivity of these cultures it is important to monitor cellular metabolism, for example the utilisa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::ec7c7d1aea1f64e364db9b6bf3289a85
http://hdl.handle.net/10044/1/44165
http://hdl.handle.net/10044/1/44165
Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (qmAb) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc-glycosylation and the mechanism behind changes in the glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::da747dc535f4df2e0d542cea7a802de3
http://hdl.handle.net/10044/1/42617
http://hdl.handle.net/10044/1/42617
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