Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier.

Autor: Maram L; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA., Michael JM; Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA., Politte H; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA., Srirama VS; Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA., Hadji A; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA., Habibi M; Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Kelly MO; Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Brookheart RT; Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Finck BN; Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Hegazy L; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA., McCommis KS; Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA., Elgendy B; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, Missouri, 63110, USA. Electronic address: belgendy@wustl.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 11; Vol. 283, pp. 117150. Date of Electronic Publication: 2024 Dec 11.