Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Polinka Hernandez-Pliego"'
Autor:
Carme Mont, Polinka Hernandez-Pliego, Toni Cañete, Ignasi Oliveras, Cristóbal Río-Álamos, Gloria Blázquez, Regina López-Aumatell, Esther Martínez-Membrives, Adolf Tobeña, Jonathan Flint, Alberto Fernández-Teruel, Richard Mott
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3283-3291 (2018)
In this study we investigate the effects of parent of origin on complex traits in the laboratory rat, with a focus on coping style behavior in stressful situations. We develop theory, based on earlier work, to partition heritability into a component
Externí odkaz:
https://doaj.org/article/ad2464890eba4978b5d26878b8bd9bfe
Autor:
Polinka Hernandez-Pliego, Daniel Biggs, Samy Alghadban, Peter Donnelly, Chris Preece, Daniela Moralli, Gang Zhang, Simon Myers, Philipp W. Becker, Anjali Gupta Hinch, Alberto Cebrian-Serrano, Benjamin Davies
Publikováno v:
Molecular Biology and Evolution
Sterility or subfertility of male hybrid offspring is commonly observed. This phenomenon contributes to reproductive barriers between the parental populations, an early step in the process of speciation. One frequent cause of such infertility is a fa
Autor:
Amine Bouchareb, Samy Alghadban, Robert Hinch, Chris Preece, Daniel Biggs, Benjamin Davies, Polinka Hernandez-Pliego
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
CRISPR/Cas9 machinery delivered as ribonucleoprotein (RNP) to the zygote has become a standard tool for the development of genetically modified mouse models. In recent years, a number of reports have demonstrated the effective delivery of CRISPR/Cas9
Autor:
Jérôme Nicod, Joseph Wood, Jean-Marie Launay, Benjamin K Yee, Arimantas Lionikas, Connie R. Bezzina, Amarjit Bhomra, Jacques Callebert, Robert W. Davies, Martin Fray, Tertius Hough, Cormac Cosgrove, Barbara Nell, Leo Goodstadt, Elisabeth M. Lodder, Richard Mott, Hayley Phelps, Jonathan Flint, Paul Klenerman, Vikte Lionikaite, Paul Franken, Steve D. M. Brown, Paul Potter, Carl Hassett, Yigal M. Pinto, Sara Wells, Alison Walling, Richard M. Aspden, Nasrin Bopp, Russell Joynson, David J. Adams, Jennifer S. Gregory, Rebecca E. McIntyre, Nick P. Talbot, Tom Weaver, Na Cai, David A. Blizard, Mark Harrison, Polinka Hernandez-Pliego, Carol Ann Remme, Peter A. Robbins, Clare Rowe
Publikováno v:
Nature genetics, 48(8), 912-918. Nature Publishing Group
Nature genetics
Nature Genetics
Nature Genetics, vol. 48, no. 8, pp. 912-918
Nature genetics
Nature Genetics
Nature Genetics, vol. 48, no. 8, pp. 912-918
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we
Autor:
Regina López-Aumatell, Carme Mont, Cristóbal Río-Álamos, Alberto Fernández-Teruel, Esther Martínez-Membrives, Polinka Hernandez-Pliego, Toni Cañete, Ignasi Oliveras, Gloria Blazquez, Jonathan Flint, Richard Mott, Adolf Tobeña
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3283-3291 (2018)
G3: Genes|Genomes|Genetics
Universitat Autònoma de Barcelona
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3283-3291 (2018)
G3: Genes|Genomes|Genetics
Altres ajuts: This work was partially supported by the Wellcome Trust core grant 090532/Z/09/Z (to C.M, P.H.P, J.F, R.M.), and by grants MINECO, DGR and "ICREA-Academia2013" (to A.F-T). In this study we investigate the effects of parent of origin on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e53d38cf196c8079e421956242688d
https://ddd.uab.cat/record/227995
https://ddd.uab.cat/record/227995
Autor:
Richard Mott, Sendu Bala, Richard Durbin, Christoffer Nellåker, Wei Yuan, Bret A. Payseur, José Afonso Guerra-Assunção, Polinka Hernandez-Pliego, Leah Rae Donahue, Deborah Janowitz, Nick Furlotte, Kim Wong, Rebecca E. McIntyre, Guy Slater, Jérôme Nicod, Thomas M. Keane, Eleazar Eskin, David J. Adams, L van der Weyden, Andrew Edwards, Charles A. Steward, Chris P. Ponting, Xiangchao Gan, Michael A. White, T G Belgard, Amarjit Bhomra, Leo Goodstadt, Ian J. Jackson, Laura G. Reinholdt, Petr Danecek, Jonathan Flint, Martin Goodson, Jim Stalker, Anne Czechanski, Helen Whitley, Peter L. Oliver, Binnaz Yalcin, Ewan Birney, Andreas Heger, Avigail Agam, James Cleak
Publikováno v:
Keane, T M, Goodstadt, L, Danecek, P, White, M A, Wong, K, Yalcin, B, Heger, A, Agam, A, Slater, G, Goodson, M, Furlotte, N A, Eskin, E, Nellåker, C, Whitley, H, Cleak, J, Janowitz, D, Hernandez-Pliego, P, Edwards, A, Belgard, T G, Oliver, P L, McIntyre, R E, Bhomra, A, Nicod, J, Gan, X, Yuan, W, van der Weyden, L, Steward, C A, Bala, S, Stalker, J, Mott, R, Durbin, R, Jackson, I J, Czechanski, A, Guerra-Assunção, J A, Donahue, L R, Reinholdt, L G, Payseur, B A, Ponting, C, Birney, E, Flint, J & Adams, D J 2011, ' Mouse genomic variation and its effect on phenotypes and gene regulation ', Nature, vol. 477, no. 7364, pp. 289-94 . https://doi.org/10.1038/nature10413
Nature
Nature, 2011, 477, pp.289-294. ⟨10.1038/nature10413⟩
Nature
Nature, 2011, 477, pp.289-294. ⟨10.1038/nature10413⟩
International audience; We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to exam
Autor:
Richard Mott, James Cleak, Deborah Janowitz, Jérôme Nicod, Thomas M. Keane, Helen Whitley, David J. Adams, Amarjit Bhomra, Christoffer Nellåker, Binnaz Yalcin, Martin Goodson, Rebekah Dutton, Kim Wong, Leo Goodstadt, Jonathan Flint, Avigail Agam, Polinka Hernandez-Pliego, Xiangchao Gan
Publikováno v:
Nature
Nature, 2011, 477, pp.326-329. ⟨10.1038/nature10432⟩
Nature, 2011, 477, pp.326-329. ⟨10.1038/nature10432⟩
International audience; Structural variation is widespread in mammalian genomes and is an important cause of disease, but just how abundant and important structural variants (SVs) are in shaping phenotypic variation remains unclear. Without knowing h
Autor:
Gloria Blázquez, Elia Vicens-Costa, Alberto Fernández-Teruel, Esther Martínez-Membrives, Delyth Graham, Max Brenner, William Valdar, Richard R. Copley, Percio S. Gulko, Eva E. Redei, Amennai Daniel Beyeen, Johan Öckinger, Rikard Holmdahl, Polinka Hernandez-Pliego, Martina Johannesson, Richard Mott, Tomas Olsson, Toni Cañete, Adolf Tobeña, Pernilla Stridh, Marc Guitart-Masip, Dominique Gauguier, Jonatan Tuncel, Regina López-Aumatell, Jonathan Flint, Lydia Giménez-Llort, Margarita Diez, Cristina Fernández-Santamaría, Anna F. Dominiczak
Publikováno v:
Genome research. 19(1)
The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular, neuroscience, and exercise physiology exists in the literat
Autor:
Polinka Hernandez-Pliego, Robert M. J. Deacon, Shoumo Bhattacharya, Stephanie Burnett, William Valdar, Youming Zhang, Graciela Nunez, Dominique Gauguier, Jonathan Flint, Leah C. Solberg, Richard Mott, Peter C. Burns, Tertius Hough, Douglas R. Higgs, William O.C.M. Cookson, J. Nicholas P. Rawlins, Paul Klenerman, Amy M. Taylor, Stuart Davidson, Carmen Arboledas-Hita
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 17(2)
Whole-genome genetic association studies in outbred mouse populations represent a novel approach to identifying the molecular basis of naturally occurring genetic variants, the major source of quantitative variation between inbred strains of mice. Me