Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Polina V. Zhdanova"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4119-4132 (2024)
8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for
Externí odkaz:
https://doaj.org/article/63d33fd6e14f4273bded503fcbdf8732
Autor:
Kristina V. Klabenkova, Polina V. Zhdanova, Ekaterina A. Burakova, Sergei N. Bizyaev, Alesya A. Fokina, Dmitry A. Stetsenko
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2007 (2024)
Staudinger reaction on the solid phase between an electronodeficit organic azide, such as sulfonyl azide, and the phosphite triester formed upon phosphoramidite coupling is a convenient method for the chemical modification of oligonucleotides at the
Externí odkaz:
https://doaj.org/article/aed8b7d6f7e0410e8053bd43d3ff61a6
Autor:
Lyubov Yu. Kanazhevskaya, Alexey A. Gorbunov, Maria V. Lukina, Denis A. Smyshliaev, Polina V. Zhdanova, Alexander A. Lomzov, Vladimir V. Koval
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1145 (2024)
Non-heme dioxygenases of the AlkB family hold a unique position among enzymes that repair alkyl lesions in nucleic acids. These enzymes activate the Fe(II) ion and molecular oxygen through the coupled decarboxylation of the 2-oxoglutarate co-substrat
Externí odkaz:
https://doaj.org/article/854324c4930541b6af0cfd32e40ec738
Publikováno v:
Data, Vol 8, Iss 3, p 57 (2023)
Fe(II)/2OG-dependent dioxygenases of the AlkB family catalyze a direct removal of alkylated damages in the course of DNA and RNA repair. A human homolog of the E. coli AlkB ALKBH3 protein is able to hydroxylate N1-methyladenine, N3-methylcytosine, an
Externí odkaz:
https://doaj.org/article/54a787627072499cae5acae3069d2673
Autor:
Polina V. Zhdanova, Alexander A. Ishchenko, Alexander A. Chernonosov, Dmitry O. Zharkov, Vladimir V. Koval
Publikováno v:
Data in Brief, Vol 40, Iss , Pp 107760- (2022)
This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the s
Externí odkaz:
https://doaj.org/article/75de9ea7c04541e68d30a3299a8f32d2
Autor:
Svetlana V. Baranova, Polina V. Zhdanova, Alexander A. Lomzov, Vladimir V. Koval, Alexander A. Chernonosov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13889 (2022)
Genome-editing systems, being some of the key tools of molecular biologists, represent a reasonable hope for progress in the field of personalized medicine. A major problem with such systems is their nonideal accuracy and insufficient selectivity. Th
Externí odkaz:
https://doaj.org/article/52a25fde6be0441c9995ab27cdf2d5e2
Autor:
Polina V. Zhdanova, Alexander A. Lomzov, Daria V. Prokhorova, Grigory A. Stepanov, Alexander A. Chernonosov, Vladimir V. Koval
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8891 (2022)
Most processes of the recognition and formation of specific complexes in living systems begin with collisions in solutions or quasi-solutions. Then, the thermodynamic regulation of complex formation and fine tuning of complexes come into play. Precis
Externí odkaz:
https://doaj.org/article/e75ee20621e44191a1c920d3811b3660
Autor:
Polina V. Zhdanova, Alexander A. Chernonosov, Daria V. Prokhorova, Grigory A. Stepanov, Lyubov Yu. Kanazhevskaya, Vladimir V. Koval
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1129 (2022)
The Cas9 endonuclease is an essential component of the CRISPR–Cas-based genome editing tools. The attainment of high specificity and efficiency of Cas9 during targetted DNA cleavage is the main problem that limits the clinical application of the CR
Externí odkaz:
https://doaj.org/article/cbbe6a058f5045138a2c2af5aed7e9f4
Autor:
Polina V, Zhdanova, Alexander A, Chernonosov, Daria V, Prokhorova, Grigory A, Stepanov, Lyubov Yu, Kanazhevskaya, Vladimir V, Koval
Publikováno v:
International journal of molecular sciences. 23(3)
The Cas9 endonuclease is an essential component of the CRISPR-Cas-based genome editing tools. The attainment of high specificity and efficiency of Cas9 during targetted DNA cleavage is the main problem that limits the clinical application of the CRIS
Autor:
Vladimir V. Koval, Dmitry O. Zharkov, Polina V. Zhdanova, Alexander A. Ishchenko, A. A. Chernonosov
Publikováno v:
Journal of Molecular Biology. 434:167334
Base excision DNA repair (BER) is necessary for removal of damaged nucleobases from the genome and their replacement with normal nucleobases. BER is initiated by DNA glycosylases, the enzymes that cleave the N-glycosidic bonds of damaged deoxynucleot