Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Polina Povarnina"'
Autor:
Aleksey Tarasiuk, Tatiana Gudasheva, Armen Mezhlumyan, Polina Povarnina, Nellya Sazonova, Anna Tallerova, Sergey Seredenin
Publikováno v:
Pharmaceuticals; Volume 15; Issue 3; Pages: 284
Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and
Publikováno v:
Medicinal Research Reviews. 41:2746-2774
To overcome the limitations of the clinical use of neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), scientists have been trying to create their low-molecular-weight mimetics having improved pharmacokinetic propert
Autor:
I. O. Logvinov, Armen G. Mezhlumyan, Anna V. Tallerova, Polina Povarnina, Tatiana A Gudasheva, T. A. Antipova, Yulia N. Firsova, Sergey B. Seredenin
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 252, p 252 (2021)
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 252, p 252 (2021)
Volume 11
Issue 2
A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo
Autor:
S. B. Seredenin, Anna V. Nadorova, Tatiana A Gudasheva, Tatiana A. Antipova, Sergei V. Nikolaev, L. G. Kolik, Anna V. Tallerova, Yulia N. Firsova, Polina Povarnina, Ksenia N. Koliasnikova
Previously it was shown that neuropeptide cyclo-L-prolylglycine (CPG) is a positive modulator of AMPA receptors, which increases BDNF level in neuronal cell cultures. The spectrum of CPG’s pharmacological effects corresponds to that of BDNF. Dipept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d74448889a8a2f193e70a77efae6b0
https://doi.org/10.5772/intechopen.91192
https://doi.org/10.5772/intechopen.91192
Autor:
Polina Povarnina, I. O. Logvinov, S. V. Kruglov, Sergey B. Seredenin, Dmitry M. Nikiforov, Tatiana A. Antipova, Tatiana A Gudasheva
Publikováno v:
CNSneurological disorders drug targets. 20(10)
Background: A dimeric dipeptide mimetic of the BDNF loop 4, bis(N-monosuccinyl- L-seryl-L-lysine) hexamethylenediamide (GSB-106) activates TrkB, PI3K/AKT, MAPK/ ERK, and PLC-γ1, and was created at the V.V. Zakusov Research Institute of Pharmacology.
Autor:
Yasuaki Nakajima, Yoro Diallo, Masanori Tokunaga, Giuseppe Loverro, Kenro Kawada, A. N. Apangwa, Hiroaki Kawabe, E. O. Uzoigwe, E. Nzau-Ngoma, Sergey B. Seredenin, B. C. J. Bikuelo, Edoardo Di Naro, Anna Maria Caringella, Michel P. Guillemin, Akihisa Tasaki, Sarmishtha Chanda, Naoto Fujiwara, Katsumasa Saito, Salvatore Andrea Mastrolia, Yuusuke Kinugasa, Takashi Ito, Ryuhei Okada, Abdoulaye Séga Diallo, E. Mboloko, Pyrrhus Fotso, Kazuchika Ohno, Hajime Shinohara, Polina Povarnina, L. Mputu, O. A. Akobi, A. B. Mairami, Yutaka Tokairin, Oumar Faye, Tatsuyuki Kawano, S. A. Akinola, E. C. Akobi, M. Mukhtar Yola, Toshihiro Matsui, Divya Prakash, Leonardo Resta, Massimo Tartagni, Takuya Okada, Babacar Diao, Mario Vicino, N. H. Madugu, E. F. Emumwen, B. Kolawole, Luca Maria Schonauer, M. M. M. Kapend, Soma Mukherjee, Akihiro Hoshino, Yosuke Ariizumi, P. O. Uyigue, A. T. Otuneye, M. Mboloko, E. G. Emumwen, Nabeel K. Al Hamzawi, M. Muthayya, Takahiro Asakage, M. A. Abdul, Mais H. Abdallah, Taro Sugimoto, Radha Annamalai, Rajat Dutta, Elenin Haussam, Vipul Kumar Sharma, L. I. Audu, U. Bawa, Tanushri Mukherjee, Tatyana A. Gudasheva, Mama Sy Diallo, B. G. Malingisi, Alberta David Nsemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed32e840aa4d2646a2ae8a4a6249f070
https://doi.org/10.9734/bpi/rtcms/v5
https://doi.org/10.9734/bpi/rtcms/v5
Autor:
Sergey B. Seredenin, S. V. Kruglov, Polina Povarnina, Yulia N. Firsova, Tatiana A Gudasheva, Anna V. Tallerova, Аrmen G. Mezhlumyan, Tatiana A. Antipova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdddce9b5913b8d3f4f7365713ccd7cb
https://doi.org/10.5772/intechopen.88244
https://doi.org/10.5772/intechopen.88244
Autor:
Polina, Povarnina, N., Firsova, Yulia, V., Tallerova, Anna, G., Mezhlumyan, Аrmen, V., Kruglov, Sergey, A., tipova, Tatiana, A., Gudasheva, Tatiana, B., Seredenin, Sergey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=intech______::419aa16d8c1dbb9acc526f65b59e629d
http://www.intechopen.com/articles/show/title/the-bdnf-loop-4-dipeptide-mimetic-bis-n-monosuccinyl-l-seryl-l-lysine-hexamethylenediamide-is-active
http://www.intechopen.com/articles/show/title/the-bdnf-loop-4-dipeptide-mimetic-bis-n-monosuccinyl-l-seryl-l-lysine-hexamethylenediamide-is-active
Publikováno v:
Journal of Biomedical Science and Engineering. 11:100-107
The dimeric dipeptide mimetics of the brain derived neurotrophic factor (BDNF) loops 1 and 4 and nerve growth factor (NGF) loop 4 were designed and synthesized at the Zakusov Research Institute of Pharmacology. There are respectively bis-(N-monosucci
Publikováno v:
Current pharmaceutical design. 25(6)
The search for new highly-effective, fast-acting antidepressant drugs is extremely relevant. Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promisin