Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Polina Lyuboslavsky"'
Autor:
Curran Sidhu, Frank E. McDonald, Noah A. Setterholm, Eldon E. Geisert, Polina Lyuboslavsky, Micah A Chrenek, Jeffrey H Boatright, Susov Dhakal, Jana T Sellers, P. Michael Iuvone, Li He
Publikováno v:
J Neurotrauma
Pressure waves from explosions or other traumatic events can damage the neurons of the eye and visual centers of the brain, leading to functional loss of vision. There are currently few treatments for such injuries that can be deployed rapidly to mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f21dcd74fcd501329001b1364caf8c0
https://doi.org/10.1089/neu.2020.7392
https://doi.org/10.1089/neu.2020.7392
Autor:
George W. Koszalka, Kamalesh P. Ruppa, Polina Lyuboslavsky, David S. Menaldino, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, Zackery W. Dentmon, Lawrence J. Wilson, Scott J. Myers, Robert Zaczek, Yesim Altas Tahirovic
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:41-52
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B-selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c1e8e93e3ee0c58291395f09218349
https://doi.org/10.1124/jpet.120.000370
https://doi.org/10.1124/jpet.120.000370
Publikováno v:
Genome Res
A wealth of genetic information is available describing single-nucleotide variants in the human population that appear to be well-tolerated and in and of themselves do not confer disease. These variant data sets contain signatures about the protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f664a59e1db2d49e7044a0fabd00c52
https://doi.org/10.1101/gr.275528.121
https://doi.org/10.1101/gr.275528.121
Autor:
Scott J, Myers, Kamalesh P, Ruppa, Lawrence J, Wilson, Yesim A, Tahirovic, Polina, Lyuboslavsky, David S, Menaldino, Zackery W, Dentmon, George W, Koszalka, Robert, Zaczek, Raymond J, Dingledine, Stephen F, Traynelis, Dennis C, Liotta
Publikováno v:
J Pharmacol Exp Ther
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B–selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db965d485c48ecef3089d635d22d3940
https://pubmed.ncbi.nlm.nih.gov/34493631
https://pubmed.ncbi.nlm.nih.gov/34493631
Autor:
Jana T Sellers, Jessica M. Hamm, Jendayi A Dixon, Yun Z. Le, Micah A Chrenek, P. Michael Iuvone, Polina Lyuboslavsky, Zhijing Zhang, Christophe P. Ribelayga, Shuo Zhang
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The present study tested the hypothesis that connexin-36 (Cx36) and gap junctions between photoreceptor cells contribute to the circadian rhythm of the photopic electroretinogram (ERG) b-wave amplitude. Methods Cone-specific disruption of Cx3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1757daefb6db9a8808f909a1954e4ed7
http://europepmc.org/articles/PMC7415284
http://europepmc.org/articles/PMC7415284
Autor:
Polina Lyuboslavsky, Kenkichi Baba, Jana T Sellers, Micah A Chrenek, Claudia Gargini, Ilaria Piano, Gianluca Tosini, P. Michael Iuvone, Li He, Shuo Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 115:13099-13104
The mammalian retina contains an autonomous circadian clock system that controls many physiological functions within this tissue. Previous studies on young mice have reported that removal of the key circadian clock gene Bmal1 from the retina affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da023cb291064c301914fa85e493dcd5
https://doi.org/10.1073/pnas.1808137115
https://doi.org/10.1073/pnas.1808137115
Autor:
Polina Lyuboslavsky, Felix L Struebing, Micah A Chrenek, P. Michael Iuvone, Ying Li, Eldon E. Geisert, Curran Sidhu, Rebecca King
Publikováno v:
Journal of Neurotrauma. 35:118-129
Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b08de59d937845d05f6abe09faf73e
https://doi.org/10.1089/neu.2017.5104
https://doi.org/10.1089/neu.2017.5104
Autor:
Lawrence J. Wilson, Scott J. Myers, Polina Lyuboslavsky, Talaignair N. Venkatraman, Daniel T. Laskowitz, Christopher D. Lascola, Haichen Wang, Michael L. James
Publikováno v:
Neurocritical Care. 20:119-131
Despite intensive research, neurological morbidity from delayed cerebral ischemia remains common after aneurysmal subarachnoid hemorrhage (SAH). In the current study, we evaluate the neuroprotective effects of a pH-dependent GluN2B subunit-selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf5b782ebdeee66a6272c2537164af9
https://doi.org/10.1007/s12028-013-9944-9
https://doi.org/10.1007/s12028-013-9944-9
Autor:
Scott J. Myers, Phuong Le, Raymond Dingledine, Dennis C. Liotta, Hasan A. Irier, Adam French, Matthew T. Geballe, Yesim Altas Tahirovic, Robert Kotloski, Ewa Gruszecka-Kowalik, Woo-Baeg Choi, Hongjie Yuan, Lawrence J. Wilson, Stephen F. Traynelis, Polina Lyuboslavsky, James O. McNamara, James P. Snyder, Keith W Easterling
Publikováno v:
Journal of Medicinal Chemistry. 51:5506-5521
Enantiomeric propanolamines have been identified as a new class of NR2B-selective NMDA receptor antagonists. The most effective agents are biaryl structures, synthesized in six steps with overall yields ranging from 11-64%. The compounds are potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873377656192885b3c6bec2d946da06f
https://doi.org/10.1021/jm8002153
https://doi.org/10.1021/jm8002153
Autor:
Jeremy Barber, Thomas F. Murray, Hongjie Yuan, Cara Mosley, Polina Lyuboslavsky, Katherine L. Nicholson, Shashank M. Dravid, Antoine G. Almonte, Robert L. Balster, Phuong Le, Adam French, Kevin Erreger, Stephen F. Traynelis, Ernest E. Murray
Publikováno v:
The Journal of Physiology. 581:107-128
We have compared the potencies of structurally distinct channel blockers at recombinant NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D receptors. The IC50 values varied with stereochemistry and subunit composition, suggesting that it may be possible to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0684eaacdd1e0c2754c12395dac9d6
https://doi.org/10.1113/jphysiol.2006.124958
https://doi.org/10.1113/jphysiol.2006.124958