Výsledky vyhledávání - "Polina I. Koroleva"

Akademický článek

Improving the Efficiency of Electrocatalysis of Cytochrome P450 3A4 by Modifying the Electrode with Membrane Protein Streptolysin O for Studying the Metabolic Transformations of Drugs

Autor: Polina I. Koroleva, Andrei A. Gilep, Sergey V. Kraevsky, Tatiana V. Tsybruk, Victoria V. Shumyantseva

Publikováno v: Biosensors, Vol 13, Iss 4, p 457 (2023)

In the present work, screen-printed electrodes (SPE) modified with a synthetic surfactant, didodecyldimethylammonium bromide (DDAB) and streptolysin O (SLO) were prepared for cytochrome P450 3A4 (CYP3A4) immobilization, direct non-catalytic and catal

Externí odkaz: https://doaj.org/article/c8364465c1f2433e91bdc428db511bfb

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Approaches for increasing the electrocatalitic efficiency of cytochrome P450 3A4

Autor: Victoria V. Shumyantseva, Polina I. Koroleva, Tatiana V. Bulko, Tatyana V. Shkel, Andrei A. Gilep, Alexander V. Veselovsky

Publikováno v: Bioelectrochemistry (Amsterdam, Netherlands). 149

The electrochemically driven cytochrome P450 reactions have great promise as drug sensing device, new drug searching tool and bioreactor with broad synthetic application. In the present work, we proposed approaches for the increasing the efficiency o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9637ea6b6e3993d8501cad6576a2625f
https://pubmed.ncbi.nlm.nih.gov/36198256

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Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity

Autor: Victoria V. Shumyantseva, Tatiana V. Bulko, Polina I. Koroleva, Evgeniya V. Shikh, Anna A. Makhova, Maryia S. Kisel, Irina V. Haidukevich, Andrei A. Gilep

Publikováno v: Processes; Volume 10; Issue 2; Pages: 383

The electrochemical properties of cytochrome P450 2C9 (CYP2C9) and polymorphic modifications P450 2C9*2 (CYP2C9*2) and P450 2C9*3 (CYP2C9*3) were studied. To analyze the comparative electrochemical and electrocatalytic activity, the enzymes were immo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d2a4b3d76dc95a9d7b3dc8af2f8411

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Predicting drug-drug interactions by electrochemically driven cytochrome P450 3A4 reactions

Autor: Sergei A. Usanov, Gennady V Sergeev, Tatiana V Bulko, Victoria V. Shumyantseva, Polina I Koroleva

Publikováno v: Drug metabolism and personalized therapyReferences. 37(3)

Objectives Human cytochrome P450 3A4 is the most abundant hepatic and intestinal Phase I enzyme that metabolizes approximately 60% marketed drugs. Simultaneous administration of several drugs may result in appearance of drug–drug interaction. Due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f0e005c416f76a100739165cfefcfa
https://pubmed.ncbi.nlm.nih.gov/34860476

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Human Cytochrome P450 2C9 and its Polymorphic Modifications: Electroanalysis, Catalytic Properties and Approaches to the Regulation of Enzymatic Activity

Autor: Polina I Koroleva, E. V. Shich, I. V. Haidukevich, Tatiana V. Bulko, Maria Kisel, Victoria V. Shumyantseva, Andrei A. Gilep, Anna Makhova

Publikováno v: SSRN Electronic Journal.

The electrochemical properties of cytochrome P450 2C9 (CYP2C9) and polymorphic modifications P450 2C9*2 (CYP2C9*2) and P450 2C9*3 (CYP2C9*3) were studied. To analyze the comparative catalytic activity, the enzymes were immobilized on electrodes modif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bece015be8e147336156722f311c3ba
https://doi.org/10.2139/ssrn.3924307

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