Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Polina Furmanova"'
Autor:
Morgan S. A. Gilman, Polina Furmanova-Hollenstein, Gabriel Pascual, Angélique B. van ‘t Wout, Johannes P. M. Langedijk, Jason S. McLellan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in
Externí odkaz:
https://doaj.org/article/9532301d0812415caee29f9be8ded047
Autor:
Dirk Roymans, Sarhad S Alnajjar, Michael B Battles, Panchan Sitthicharoenchai, Polina Furmanova-Hollenstein, Peter Rigaux, Joke Van den Berg, Leen Kwanten, Marcia Van Ginderen, Nick Verheyen, Luc Vranckx, Steffen Jaensch, Eric Arnoult, Richard Voorzaat, Jack M. Gallup, Alejandro Larios-Mora, Marjolein Crabbe, Dymphy Huntjens, Pierre Raboisson, Johannes P. Langedijk, Mark R. Ackermann, Jason S McLellan, Sandrine Vendeville, Anil Koul
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in
Externí odkaz:
https://doaj.org/article/a53af0caadf64c108081ce0c70f541ee
Autor:
Harrison G Jones, Tina Ritschel, Gabriel Pascual, Just P J Brakenhoff, Elissa Keogh, Polina Furmanova-Hollenstein, Ellen Lanckacker, Jehangir S Wadia, Morgan S A Gilman, R Anthony Williamson, Dirk Roymans, Angélique B van 't Wout, Johannes P Langedijk, Jason S McLellan
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006935 (2018)
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and the elderly, and yet there remains no effective treatment or vaccine. The surface of the virion is decorated with the fusion glycoprotein (
Externí odkaz:
https://doaj.org/article/934d8568511a4a31a4fe4f3f7569d4dc
Autor:
Angélique B. van ‘t Wout, Jason S. McLellan, R. Anthony Williamson, Elissa Keogh, Tina Ritschel, Harrison G. Jones, Just P. J. Brakenhoff, Dirk Roymans, Ellen Lanckacker, Gabriel Pascual, Jehangir Wadia, Polina Furmanova-Hollenstein, Johannes P. M. Langedijk, Morgan S.A. Gilman
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006935 (2018)
PLoS Pathogens
PLoS Pathogens
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and the elderly, and yet there remains no effective treatment or vaccine. The surface of the virion is decorated with the fusion glycoprotein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de6a1fe3725bd9fca5136d670fc9090
http://europepmc.org/articles/PMC5856423?pdf=render
http://europepmc.org/articles/PMC5856423?pdf=render
Autor:
Sarhad Alnajjar, Alejandro Larios-Mora, Marjolein Crabbe, Dymphy Huntjens, Eric Arnoult, Nick Verheyen, Jason S. McLellan, Mark R. Ackermann, Jack M. Gallup, Anil Koul, Leen Kwanten, Michael B. Battles, Steffen Jaensch, Joke Van den Berg, Luc Vranckx, Marcia Van Ginderen, Dirk Roymans, Panchan Sitthicharoenchai, Richard Voorzaat, Peter Rigaux, Sandrine Vendeville, Pierre Jean-Marie Bernard Raboisson, Polina Furmanova-Hollenstein, Johannes P. M. Langedijk
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Respiratory syncytial virus is a major cause of acute lower respiratory tract infection in young children, immunocompromised adults, and the elderly. Intervention with small-molecule antivirals specific for respiratory syncytial virus presents an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57d4700de9a5f9e943935ea4ad35df5
https://pubmed.ncbi.nlm.nih.gov/28761099
https://pubmed.ncbi.nlm.nih.gov/28761099
Autor:
Jennifer Lum, Angelique van 't Wout, Jerome Custer, Polina Furmanova, Anthony Williamson, Jason S. McLellan, Gabriel Pasqual, Jay Wadia, Johannes P. M. Langedijk, Morgan S.A. Gilman
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:a312-a312
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0de50d45e700ddc2170eecd97232c3
https://doi.org/10.1107/s0108767318096885
https://doi.org/10.1107/s0108767318096885
Autor:
Carla Rohrer Bley, Martin Pruschy, Paul M.J. McSheehy, Katrin Orlowski, Polina Furmanova, Wolfram Jochum, Van Vuong
Publikováno v:
Clinical Cancer Research. 15:1335-1342
Purpose: The combined treatment modality of ionizing radiation (IR) and the clinically relevant microtubule-stabilizing compound patupilone (epothilone B, EPO906) is a promising approach for anticancer therapy. Here, we investigated the role of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15fd4bbd1bdd660921c6ecea84711f5
https://doi.org/10.1158/1078-0432.ccr-08-0969
https://doi.org/10.1158/1078-0432.ccr-08-0969
Autor:
Dirk Roymans, Anil Koul, Polina Furmanova-Hollenstein, Heather M. Costello, Michael B. Battles, Tim H. M. Jonckers, Steffen Jaensch, Luc Vranckx, Eric Arnoult, Johannes P. M. Langedijk, P. Vink, Supranee Chaiwatpongsakorn, Leen Kwanten, Jason S. McLellan, Mark E. Peeples
Respiratory syncytial virus (RSV) is a leading cause of pneumonia and bronchiolitis in young children and the elderly. Therapeutic small molecules have been developed that bind the RSV F glycoprotein and inhibit membrane fusion, yet their binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2203a2a9c35ee1bed9f9de1aea27f180
https://europepmc.org/articles/PMC4731865/
https://europepmc.org/articles/PMC4731865/
Autor:
Lies Bogaert, Myra N. Widjojoatmodjo, Roland Zahn, Polina Furmanova-Hollenstein, Jason S. McLellan, Daphné Truan, Ilona J. M. Bisschop, Anders Krarup, Pascale Bouchier, Johannes P. M. Langedijk, Hanneke Schuitemaker
Publikováno v:
Nature Communications
Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6746af14083c41e3bbc7a913956193
https://doi.org/10.1038/ncomms9143
https://doi.org/10.1038/ncomms9143
Autor:
James D. Marks, Maria Russeva, Yu Zhou, Jennifer L. Garrison, Polina Furmanova, Qing-An Yuan, Gregory P. Adams, Louis M. Weiner, Heidi H. Simmons, Tara Heitner, Jianlong Lou, Matthew K. Robinson, Eva M. Horak
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 20:603-613
The members of the epidermal growth factor receptor (EGFR) family are over expressed in a variety of malignancies and are frequently linked to aggressive disease and a poor prognosis. Although clinically effective monoclonal antibodies (MAbs) have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0d51ca3d9a71f51e2a77b78a3c7bf2
https://doi.org/10.1089/cbr.2005.20.603
https://doi.org/10.1089/cbr.2005.20.603