Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Polina Denichenko"'
Autor:
Polina Denichenko, Maxim Mogilevsky, Antoine Cléry, Thomas Welte, Jakob Biran, Odelia Shimshon, Georgina D. Barnabas, Miri Danan-Gotthold, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Frédéric H. Allain, Tamar Geiger, Gil Levkowitz, Rotem Karni
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.
Externí odkaz:
https://doaj.org/article/56b48a0782e64173831607d2f384bb24
Autor:
Vered Ben-Hur, Polina Denichenko, Zahava Siegfried, Avi Maimon, Adrian Krainer, Ben Davidson, Rotem Karni
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 103-115 (2013)
Ribosomal S6 kinase 1 (S6K1) is a major mTOR downstream signaling molecule that regulates cell size and translation efficiency. Here, we report that short isoforms of S6K1 are overproduced in breast cancer cell lines and tumors. Overexpression of S6K
Externí odkaz:
https://doaj.org/article/ef605f8684744ead9409e441b207ff99
Autor:
Gil Levkowitz, Odelia Shimshon, Polina Denichenko, Antoine Cléry, Rotem Karni, Jakob Biran, Frédéric H.-T. Allain, Miri Danan-Gotthold, Maxim Mogilevsky, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Tamar Geiger, Georgina D. Barnabas, Thomas Welte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9386b254657bddea24726eaa05e26ef
https://doi.org/10.1038/s41467-019-09523-0
https://doi.org/10.1038/s41467-019-09523-0
Autor:
Walter Kolch, Jens Rauch, Rotem Karni, Ilan Stein, Polina Denichenko, Asaf Shilo, Eli Pikarsky, Vered Ben Hur, Lars Zender
Publikováno v:
RNA. 20:505-515
In recent years, it has become clear that splicing factors play a direct role in cancer development. We showed previously that splicing factors SRSF1, SRSF6, and hnRNP A2/B1 are up-regulated in several cancers and can act as oncogenes when up-regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4acc1564bddb2e743a5005fff82c54
https://doi.org/10.1261/rna.042259.113
https://doi.org/10.1261/rna.042259.113
Autor:
Arieh Ingber, Polina Denichenko, Gal Markel, Claes D. Enk, Malka Hochberg, Leon Gilead, Yael Nemlich, Yulia Feiler, Rotem Karni
Publikováno v:
Archives of dermatological research. 305(6)
Non-melanoma skin cancers (NMSC) are the most common malignancies in caucasians worldwide. Insulin-like growth factor-binding protein-7 (IGFBP7) was suggested to function as a tumor suppressor gene in several cancers, and to play a role in the prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e089680204d6d0b6cab2054b5baf4c9d
https://pubmed.ncbi.nlm.nih.gov/23543219
https://pubmed.ncbi.nlm.nih.gov/23543219
Autor:
Ben Davidson, Avi Maimon, Polina Denichenko, Zahava Siegfried, Vered Ben-Hur, Adrian R. Krainer, Rotem Karni
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 103-115 (2013)
SummaryRibosomal S6 kinase 1 (S6K1) is a major mTOR downstream signaling molecule that regulates cell size and translation efficiency. Here, we report that short isoforms of S6K1 are overproduced in breast cancer cell lines and tumors. Overexpression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f7fe713d8647434083d2dc8d8f8ba0