Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Policarpo Ademar Sales Júnior"'
Autor:
Marina Malheiros Araújo Silvestrini, Glaucia Diniz Alessio, Bruna Estefânia Diniz Frias, Policarpo Ademar Sales Júnior, Márcio Sobreira Silva Araújo, Carolina Malheiros Araújo Silvestrini, Gustavo Eustáquio Brito Alvim de Melo, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Helen Rodrigues Martins
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chagas disease, caused by Trypanosoma cruzi, remains a serious public health problem worldwide. The parasite was subdivided into six distinct genetic groups, called “discrete typing units” (DTUs), from TcI to TcVI. Several studies have indicated
Externí odkaz:
https://doaj.org/article/a0a34ef2e0804b9282a9ea6e5f5f914b
Autor:
Glaucia Diniz Alessio, Fernanda Fortes de Araújo, Policarpo Ademar Sales Júnior, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Marcelo Antônio Pascoal Xavier, Andréa Teixeira-Carvalho, Marta de Lana, Olindo Assis Martins-Filho
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006140 (2018)
The methods currently available for genotype-specific diagnosis of T. cruzi infection still present relevant limitations, especially to identify mixed infection. In the present investigation, we have evaluated the performance of Chagas-Flow ATE-IgG2a
Externí odkaz:
https://doaj.org/article/e12e0afac31a4b9e92472e889651b2a6
Autor:
Glaucia Diniz Alessio, Fernanda Fortes de Araújo, Denise Fonseca Côrtes, Policarpo Ademar Sales Júnior, Daniela Cristina Lima, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Marcelo Antônio Pascoal Xavier, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Marta de Lana
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005444 (2017)
Distinct Trypanosoma cruzi genotypes have been considered relevant for patient management and therapeutic response of Chagas disease. However, typing strategies for genotype-specific serodiagnosis of Chagas disease are still unavailable and requires
Externí odkaz:
https://doaj.org/article/270e5e88f9ed4cc4b0152e1d4212657c
Autor:
Stefânia Neiva Lavorato, Policarpo Ademar Sales Júnior, Silvane Maria Fonseca Murta, Alvaro José Romanha, Ricardo José Alves/
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 110, Iss 4, Pp 566-568 (2015)
We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentr
Externí odkaz:
https://doaj.org/article/ebc073d2e53f40df93a1a0921428ba00
Autor:
Policarpo Ademar Sales Júnior, Celso Oliveira Rezende Júnior, Mireille Le Hyaric, Mauro Vieira de Almeida, Alvaro José Romanha
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 3, Pp 362-364 (2014)
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6
Externí odkaz:
https://doaj.org/article/2e67d352949141d487015ec5d609d6b3
Autor:
Marcela Silva Lopes, Policarpo Ademar Sales Júnior, Amanda Gervásio Ferreira Lopes, Maria Irene Yoshida, Thais Horta Alvares da Silva, Alvaro José Romanha, Ricardo José Alves, Renata Barbosa de Oliveira
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 8, Pp 1055-1057 (2011)
In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-I:
Externí odkaz:
https://doaj.org/article/37993d03deef4ddab4983f56be73655f
Publikováno v:
Drugs and Drug Candidates, Vol 2, Iss 2, Pp 477-485 (2023)
Chagas disease is caused by the parasite protozoan Trypanosoma cruzi (T. cruzi) and affects millions of people in over 21 countries in around the world. The main forms of treatment of this disease, benznidazole and nifurtimox, present low cure rates
Externí odkaz:
https://doaj.org/article/3e57df69a7ee4c929f8cd36f91814274
Autor:
Jéssica Hickson, Lucas Felipe Almeida Athayde, Thainá Godinho Miranda, Policarpo Ademar Sales Junior, Anderson Coqueiro dos Santos, Lúcia Maria da Cunha Galvão, Antônia Cláudia Jácome da Câmara, Daniella Castanheira Bartholomeu, Rita de Cássia Moreira de Souza, Silvane Maria Fonseca Murta, Laila Alves Nahum
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Background Components of the antioxidant defense system in Trypanosoma cruzi are potential targets for new drug development. Superoxide dismutases (SODs) constitute key components of antioxidant defense systems, removing excess superoxide an
Externí odkaz:
https://doaj.org/article/190c5e36530344508c02176cc599eba1
Autor:
Cheyene Almeida Celestino Menozzi, Rodolfo Rodrigo Florido França, Pedro Henrique Luccas, Mayara dos Santos Baptista, Tácio Vinício Amorim Fernandes, Lucas Villas Bôas Hoelz, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Alvaro Romanha, Bárbara Verena Dias Galvão, Marcela de Oliveira Macedo, Alana da Cunha Goldstein, Carlos Fernando Araujo-Lima, Israel Felzenszwalb, Maria Cristina Nonato, Frederico Silva Castelo-Branco, Nubia Boechat
Publikováno v:
Molecules, Vol 28, Iss 22, p 7461 (2023)
Chagas disease (CD), which is caused by Trypanosoma cruzi and was discovered more than 100 years ago, remains the leading cause of death from parasitic diseases in the Americas. As a curative treatment is only available for the acute phase of CD, the
Externí odkaz:
https://doaj.org/article/ba47db5727564f948cabf4eecf270517
Autor:
Gabriela Maciel Diogo, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, Jason Guy Taylor
Publikováno v:
Molecules, Vol 25, Iss 2, p 397 (2020)
Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended
Externí odkaz:
https://doaj.org/article/a4bf601382a04d96b844e47725579d0d