Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathways.

Autor: Moysidou GS; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece.; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University Faculty of Medicine, Athens, Greece., Garantziotis P; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece.; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany., Sentis G; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Nikoleri D; Laboratory of Auoimmunity-Inflammation, Institute of Molecular Biology and Biotechnology, Heraklion, Greece., Malissovas N; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Nikoloudaki M; Rheumatology, Clinical Immunology and Allergy Department, University of Crete School of Medicine, Heraklion, Greece., Stergioti EM; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Polia S; Rheumatology, Clinical Immunology and Allergy Department, University of Crete School of Medicine, Heraklion, Greece., Paschalidis N; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Filia A; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Grigoriou M; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece.; 1st Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace - Alexandropoulis Campus, Alexandroupolis, Greece., Nikolopoulos D; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece.; Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Kapsala N; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University Faculty of Medicine, Athens, Greece., Katechis S; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University School of Medicine, Athens, Greece., Fanouriakis A; 4th Department of Medicine, National and Kapodistrian University Faculty of Medicine, Athens, Greece., Bertsias G; Rheumatology, Clinical Immunology and Allergy Department, University of Crete School of Medicine, Heraklion, Greece.; Laboratory of Autoimmunity-Inflammation, Institute of Molecular Biology and Biotechnology, Heraklion, Greece., Boumpas DT; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece boumpasd@uoc.gr.; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University Faculty of Medicine, Athens, Greece.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.