Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice.

Autor: Salaga M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Polepally PR; Department of BioMolecular Sciences, Division of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA., Zielinska M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Marynowski M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Fabisiak A; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Murawska N; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Sobczak K; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Sacharczuk M; Department of Molecular Cytogenetic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland., Do Rego JC; Platform of Behavioural Analysis (SCAC), Institute for Research and Innovation in Biomedicine (IRIB), Faculty of Medicine & Pharmacy, University of Rouen, Rouen Cedex, France., Roth BL; Department of Pharmacology, Division of Chemical Biology and Medicinal Chemistry, Medical School, NIMH Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, NC, USA., Zjawiony JK; Department of BioMolecular Sciences, Division of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA., Fichna J; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2015 Sep; Vol. 172 (17), pp. 4331-41. Date of Electronic Publication: 2015 Jul 14.

The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.

Autor: White KL; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Robinson JE; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Zhu H; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., DiBerto JF; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Polepally PR; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Zjawiony JK; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Nichols DE; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Malanga CJ; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.)., Roth BL; Department of Pharmacology (K.L.W., H.Z., D.E.N., B.L.R.), Department of Neurology (J.E.R., J.F.D., C.J.M.), and Bowles Center for Alcohol Studies (J.E.R., C.J.M.), University of North Carolina, Chapel Hill, North Carolina; and Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.) bryan_roth@med.unc.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2015 Jan; Vol. 352 (1), pp. 98-109. Date of Electronic Publication: 2014 Oct 15.

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.

Autor: Polepally PR; Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA., Huben K; Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA; Institute of Organic Chemistry, Technical University of Lodz, 90-924 Lodz, Poland., Vardy E; Department of Pharmacology, Division of Chemical Biology and Medicinal Chemistry, Medical School, NIMH Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, NC 27599, USA., Setola V; Department of Pharmacology, Division of Chemical Biology and Medicinal Chemistry, Medical School, NIMH Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, NC 27599, USA., Mosier PD; Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298-0540, USA., Roth BL; Department of Pharmacology, Division of Chemical Biology and Medicinal Chemistry, Medical School, NIMH Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, NC 27599, USA., Zjawiony JK; Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA. Electronic address: jordan@olemiss.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2014 Oct 06; Vol. 85, pp. 818-29. Date of Electronic Publication: 2014 Aug 23.

Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.

Autor: Sałaga M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Polepally PR; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Sobczak M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Grzywacz D; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Kamysz W; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Sibaev A; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Storr M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Do Rego JC; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Zjawiony JK; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.)., Fichna J; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (M.Sa., M.So., J.F.); Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (P.R.P., J.K.Z.); Research and Development Laboratory, Lipopharm.pl, Zblewo, Poland (D.G.); Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland (W.K.); Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany (A.S., M.St.); and Platform of Behavioural Analysis, Institute for Research and Innovation in Biomedicine, Faculty of Medicine and Pharmacy, University of Rouen, Rouen Cedex, France (J.C.D.R.) jakub.fichna@umed.lodz.pl.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2014 Jul; Vol. 350 (1), pp. 69-78.

Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.

Autor: Polepally PR; Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA., White K, Vardy E, Roth BL, Ferreira D, Zjawiony JK

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 May 15; Vol. 23 (10), pp. 2860-2. Date of Electronic Publication: 2013 Apr 04.