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Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function.

Autor: Piol D; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy.; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Tosatto L; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.; Institute of Biophysics, Consiglio Nazionale delle Ricerche (CNR), Trento, Italy., Zuccaro E; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Anderson EN; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Falconieri A; Department of Biomedical Sciences, University of Padova, Padova, Italy., Polanco MJ; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Marchioretti C; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Lia F; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., White J; Department of Pathology and Laboratory Medicine, Department of Neurology, Department of Biological Chemistry, and the UCI Institute for Neurotherapeutics, University of California, Irvine, CA 92697, USA., Bregolin E; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Minervini G; Department of Biomedical Sciences, University of Padova, Padova, Italy., Parodi S; Istituto Italiano di Tecnologia, Genova, Italy., Salvatella X; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; ICREA, Passeig Lluís Companys 23, Barcelona, Spain., Arrigoni G; Department of Biomedical Sciences, University of Padova, Padova, Italy., Ballabio A; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy.; Department of Medical and Translational Science, Federico II University, Naples, Italy.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., La Spada AR; Department of Pathology and Laboratory Medicine, Department of Neurology, Department of Biological Chemistry, and the UCI Institute for Neurotherapeutics, University of California, Irvine, CA 92697, USA., Tosatto SCE; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Padova, Italy., Sambataro F; Padova Neuroscience Center, Padova, Italy.; Department of Neuroscience, University of Padova, Padova, Italy., Medina DL; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Department of Medical and Translational Science, Federico II University, Naples, Italy., Pandey UB; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Basso M; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Pennuto M; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy.; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

Publikováno v: Science advances [Sci Adv] 2023 Jan 06; Vol. 9 (1), pp. eade1694. Date of Electronic Publication: 2023 Jan 06.

Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism.

Autor: Chivet M; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Marchioretti C; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy., Pirazzini M; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy., Piol D; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy., Scaramuzzino C; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy., Polanco MJ; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Romanello V; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy., Zuccaro E; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy., Parodi S; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy., D'Antonio M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy., Rinaldi C; Department of Paediatrics, University of Oxford, OX1 3QX Oxford, UK., Sambataro F; Department of Neuroscience (DNS), University of Padova, 35128 Padova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy., Pegoraro E; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy.; Department of Neuroscience (DNS), University of Padova, 35128 Padova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy., Soraru G; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy.; Department of Neuroscience (DNS), University of Padova, 35128 Padova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy., Pandey UB; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Sandri M; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy., Basso M; Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Pennuto M; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy.; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy.

Publikováno v: Cells [Cells] 2020 Jan 30; Vol. 9 (2). Date of Electronic Publication: 2020 Jan 30.