Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function.

Autor: Piol D; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy.; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Tosatto L; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.; Institute of Biophysics, Consiglio Nazionale delle Ricerche (CNR), Trento, Italy., Zuccaro E; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Anderson EN; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Falconieri A; Department of Biomedical Sciences, University of Padova, Padova, Italy., Polanco MJ; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Marchioretti C; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Lia F; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., White J; Department of Pathology and Laboratory Medicine, Department of Neurology, Department of Biological Chemistry, and the UCI Institute for Neurotherapeutics, University of California, Irvine, CA 92697, USA., Bregolin E; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Minervini G; Department of Biomedical Sciences, University of Padova, Padova, Italy., Parodi S; Istituto Italiano di Tecnologia, Genova, Italy., Salvatella X; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; ICREA, Passeig Lluís Companys 23, Barcelona, Spain., Arrigoni G; Department of Biomedical Sciences, University of Padova, Padova, Italy., Ballabio A; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy.; Department of Medical and Translational Science, Federico II University, Naples, Italy.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., La Spada AR; Department of Pathology and Laboratory Medicine, Department of Neurology, Department of Biological Chemistry, and the UCI Institute for Neurotherapeutics, University of California, Irvine, CA 92697, USA., Tosatto SCE; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Padova, Italy., Sambataro F; Padova Neuroscience Center, Padova, Italy.; Department of Neuroscience, University of Padova, Padova, Italy., Medina DL; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Department of Medical and Translational Science, Federico II University, Naples, Italy., Pandey UB; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Basso M; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Pennuto M; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.; Padova Neuroscience Center, Padova, Italy.; Dulbecco Telethon Institute (DTI), Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

Publikováno v: Science advances [Sci Adv] 2023 Jan 06; Vol. 9 (1), pp. eade1694. Date of Electronic Publication: 2023 Jan 06.

Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism.

Autor: Chivet M; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Marchioretti C; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy., Pirazzini M; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy., Piol D; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy., Scaramuzzino C; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy., Polanco MJ; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Romanello V; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy., Zuccaro E; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy., Parodi S; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy., D'Antonio M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy., Rinaldi C; Department of Paediatrics, University of Oxford, OX1 3QX Oxford, UK., Sambataro F; Department of Neuroscience (DNS), University of Padova, 35128 Padova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy., Pegoraro E; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy.; Department of Neuroscience (DNS), University of Padova, 35128 Padova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy., Soraru G; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy.; Department of Neuroscience (DNS), University of Padova, 35128 Padova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy., Pandey UB; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Sandri M; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy., Basso M; Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Pennuto M; Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.; Department of Biomedical Sciences (DBS), University of Padova, 35131 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.; Myology Center (Cir-Myo), University of Padova, 35129 Padova, Italy.; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy.; Padova Neuroscience Center (PNC), 35100 Padova, Italy.

Publikováno v: Cells [Cells] 2020 Jan 30; Vol. 9 (2). Date of Electronic Publication: 2020 Jan 30.

Pituitary Adenylyl Cyclase Activating Polypeptide (PACAP) Signaling and the Cell Cycle Machinery in Neurodegenerative Diseases.

Autor: Polanco MJ; Laboratory of Pharmacology and Toxicology, Department of Pharmaceutical and Health Sciences, Faculty of Pharmacy, San Pablo CEU University, Madrid, Spain., Pennuto M; Department of Biomedical Sciences, University of Padova, 35100 Padova, Italy.

Publikováno v: Current pharmaceutical design [Curr Pharm Des] 2018; Vol. 24 (33), pp. 3878-3891.

Mutations in TGM6 induce the unfolded protein response in SCA35.

Autor: Tripathy D; Laboratory of Transcriptional Neurobiology, Centre for Integrative Biology (CIBIO), University of Trento, Trento (TN), Italy., Vignoli B; Laboratory of Neural Stem Cells and Neurogenesis, Centre for Integrative Biology (CIBIO), University of Trento, Trento (TN), Italy., Ramesh N; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Polanco MJ; Dulbecco Telethon Institute Lab of Neurodegenerative Diseases, Centre for Integrative Biology (CIBIO), University of Trento, Trento (TN), Italy., Coutelier M; INSERM U 1127, Centre National de la Recherche Scientifique UMR 7225, UMRS 1127, Université Pierre et Marie Curie (Paris 06), Sorbonne Universités, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France., Stephen CD; Ataxia Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Canossa M; Laboratory of Neural Stem Cells and Neurogenesis, Centre for Integrative Biology (CIBIO), University of Trento, Trento (TN), Italy., Monin ML; INSERM U 1127, Centre National de la Recherche Scientifique UMR 7225, UMRS 1127, Université Pierre et Marie Curie (Paris 06), Sorbonne Universités, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France., Aeschlimann P; Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK., Turberville S; Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK., Aeschlimann D; Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK., Schmahmann JD; Ataxia Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hadjivassiliou M; Academic Department of Neurosciences, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK., Durr A; INSERM U 1127, Centre National de la Recherche Scientifique UMR 7225, UMRS 1127, Université Pierre et Marie Curie (Paris 06), Sorbonne Universités, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France., Pandey UB; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Pennuto M; Dulbecco Telethon Institute Lab of Neurodegenerative Diseases, Centre for Integrative Biology (CIBIO), University of Trento, Trento (TN), Italy., Basso M; Laboratory of Transcriptional Neurobiology, Centre for Integrative Biology (CIBIO), University of Trento, Trento (TN), Italy.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Oct 01; Vol. 26 (19), pp. 3749-3762.

HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27.

Autor: Wei Du¹, Kai Guo¹, Peng Wang¹, Jianye Zhong¹, Ning Jiang¹ jiangn6@smu.edu.cn

Publikováno v: Journal of Cancer. 2024, Vol. 15 Issue 3, p645-658. 14p.