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Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity.

Autor: Appios A; Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Davies J; Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Sirvent S; Systems Immunology Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK., Henderson S; Bill Lyons Informatics Centre, Cancer Institute, University College London, London WC1E 6DD, UK., Trzebanski S; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 76100, Israel., Schroth J; William Harvey Research Institute, Barts & London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Law ML; William Harvey Research Institute, Barts & London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Carvalho IB; Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Pinto MM; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, EH16 4UU, UK., Carvalho C; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, EH16 4UU, UK., Kan HY; Bill Lyons Informatics Centre, Cancer Institute, University College London, London WC1E 6DD, UK., Lovlekar S; Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK., Major C; University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK., Vallejo A; Systems Immunology Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK., Hall NJ; University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK., Ardern-Jones M; University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.; Dermatopharmacology, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Liu Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Ginhoux F; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore.; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire, Villejuif 94800, France., Henson SM; William Harvey Research Institute, Barts & London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Gentek R; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, EH16 4UU, UK., Emmerson E; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK., Jung S; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 76100, Israel., Polak ME; Systems Immunology Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Bennett CL; Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.

Publikováno v: Science immunology [Sci Immunol] 2024 Sep 06; Vol. 9 (99), pp. eadp0344. Date of Electronic Publication: 2024 Sep 06.

Skin programming of inflammatory responses to Staphylococcus aureus is compartmentalized according to epidermal keratinocyte differentiation status.

Autor: Clayton K; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Holbrook DJ; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Vallejo A; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Porter G; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Sirvent S; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Davies J; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Pople J; Unilever, Colworth Science Park, Sharnbrook, Bedford, UK., Lim FL; Unilever, Colworth Science Park, Sharnbrook, Bedford, UK., Christodoulides M; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK., Polak ME; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK., Ardern-Jones MR; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK.; Department of Dermatology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.

Publikováno v: The British journal of dermatology [Br J Dermatol] 2023 Feb 22; Vol. 188 (3), pp. 396-406.

Effect of colonisation with Neisseria lactamica on cross-reactive anti-meningococcal B-cell responses: a randomised, controlled, human infection trial.

Autor: Dale AP; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: a.p.dale@soton.ac.uk., Theodosiou AA; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Gbesemete DF; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Guy JM; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Jones EF; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Hill AR; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Ibrahim MM; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., de Graaf H; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Ahmed M; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Faust SN; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Gorringe AR; UK Health Security Agency, Porton Down, Salisbury, UK., Polak ME; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Laver JR; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Read RC; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2022 Dec; Vol. 3 (12), pp. e931-e943.

Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.

Autor: Penrice-Randal R; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Dong X; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Shapanis AG; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Gardner A; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Harding N; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Legebeke J; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton National Health Service (NHS) Foundation Trust, University of Southampton, Southampton, United Kingdom., Lord J; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Vallejo AF; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Poole S; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton National Health Service (NHS) Foundation Trust, University of Southampton, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Brendish NJ; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton National Health Service (NHS) Foundation Trust, University of Southampton, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Hartley C; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Williams AP; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom., Wheway G; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Polak ME; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Strazzeri F; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Schofield JPR; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Skipp PJ; TopMD Precision Medicine Ltd, Southampton, United Kingdom.; Centre for Proteomic Research, School of Biological Sciences, University of Southampton, Southampton, United Kingdom., Hiscox JA; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom.; ASTAR Infectious Diseases Laboratories (ASTAR ID Labs), Agency for Science, Technology and Research (ASTAR) Singapore, Singapore, Singapore., Clark TW; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton National Health Service (NHS) Foundation Trust, University of Southampton, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Baralle D; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton National Health Service (NHS) Foundation Trust, University of Southampton, Southampton, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Sep 20; Vol. 13, pp. 988685. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022).