Study of Microstructure, Hydrogen Solubility, and Corrosion of Ta-Modified Zr–1Nb Alloys for Nuclear Applications

Autor: Ferreirós, P. A., Polack, E. C.Savoy, Lanzani, L. A., Alonso, P. R., Quirós, D. P., Mieza, J. I., Zelaya, E., Knowles, A. J., Rubiolo, G. H.

Publikováno v: Ferreirós, P A, Polack, E C S, Lanzani, L A, Alonso, P R, Quirós, D P, Mieza, J I, Zelaya, E, Knowles, A J & Rubiolo, G H 2022, Study of Microstructure, Hydrogen Solubility, and Corrosion of Ta-Modified Zr–1Nb Alloys for Nuclear Applications . in TMS 2022 151st Annual Meeting and Exhibition Supplemental Proceedings . Springer, Minerals, Metals and Materials Series, pp. 1352-1362, 151st Annual Meeting and Exhibition of The Minerals, Metals and Materials Society, TMS 2022, Anaheim, United States, 27/02/22 . https://doi.org/10.1007/978-3-030-92381-5_129

Modified Zr–1Nb alloys with Ta additions is a potential strategy to improve structural alloys for nuclear reactors. The effects of Ta on microstructural stability and resistance to corrosion of Zr–1Nb alloys were systematically investigated and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=355e65625b88::450db4e9ddaa5f98b49c92cc8a74e078
https://cris.vtt.fi/en/publications/e69746d5-e4d1-4a00-a3d9-89d434513ba1

An approximation strategy on the Grassmann manifold to compute accurate SCF initial guesses for repeated calculations at different geometries

Autor: Polack, E., Mikhalev, A., Dusson, Geneviève, Stamm, B., Lipparini, F.

Repeated computations on the same molecular system, but with different geometries, are often performed in quantum chemistry, for instance, in ab-initio molecular dynamics simulations or geometry optimizations. While many efficient strategies exist to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______212::168ee7e17cc13ae0b51a2f139b2525c9
https://hal.archives-ouvertes.fr/hal-02519271v2/document

Scientific and Regulatory Policy Committee Best Practices: Recommended ("Best") Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies.

Autor: Bolon B; GEMpath Inc., Longmont, Colorado, USA., Francke S; U.S. Food and Drug Administration, College Park, Maryland, USA., Caverly Rae JM; Corteva Agriscience, Indianapolis, Indiana, USA., Polack E; Biogen, Cambridge, Massachusetts, USA., Regan KS; Regan Path/Tox Services, Ashland, Ohio, USA., McInnes EF; Syngenta, Bracknell, UK., Young JK; StageBio, Mason, Ohio, USA., Keane K; Blueprint Medicines, Cambridge, Massachusetts, USA., Perry R; Pfizer, Groton, Connecticut, USA., Romeike A; Labcorp Early Development Services GmbH, Münster, Germany., Colman K; Novartis Institutes for Biomedical Research, Inc., Cambridge, Massachusetts, USA., Jensen K; Chapel Hill, North Carolina, USA., Nakano-Ito K; Eisai Co., Ltd., Tokyo, Japan., Galbreath EJ; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.

Publikováno v: Toxicologic pathology [Toxicol Pathol] 2022 Dec; Vol. 50 (8), pp. 930-941. Date of Electronic Publication: 2022 Nov 14.

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.

Autor: Hopkins BT; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Bame E; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Bajrami B; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Black C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Bohnert T; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Boiselle C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Burdette D; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Burns JC; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Delva L; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Donaldson D; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Grater R; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Gu C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Hoemberger M; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Johnson J; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Kapadnis S; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., King K; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Lulla M; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Ma B; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Marx I; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Magee T; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Meissner R; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Metrick CM; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Mingueneau M; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Murugan P; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Otipoby KL; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Polack E; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Poreci U; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Prince R; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Roach AM; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Rowbottom C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Santoro JC; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Schroeder P; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Tang H; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Tien E; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Zhang F; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States., Lyssikatos J; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jan 27; Vol. 65 (2), pp. 1206-1224. Date of Electronic Publication: 2021 Nov 04.

Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.

Autor: Ma B; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bohnert T; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Otipoby KL; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Tien E; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Arefayene M; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bai J; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bajrami B; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bame E; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chan TR; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Humora M; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., MacPhee JM; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Marcotte D; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Mehta D; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Metrick CM; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Moniz G; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Polack E; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Poreci U; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Prefontaine A; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Sheikh S; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Schroeder P; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Smirnakis K; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Zhang L; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Zheng F; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hopkins BT; Research & Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12526-12541. Date of Electronic Publication: 2020 Aug 06.