Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pol Picón-Pagès"'
Autor:
Julia Sala-Jarque, Vanessa Gil, Pol Andrés-Benito, Inés Martínez-Soria, Pol Picón-Pagès, Félix Hernández, Jesús Ávila, José Luis Lanciego, Mario Nuvolone, Adriano Aguzzi, Rosalina Gavín, Isidro Ferrer, José Antonio del Río
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The cellular prion protein (PrPC) plays many roles in the developing and adult brain. In addition, PrPC binds to several amyloids in oligomeric and prefibrillar forms and may act as a putative receptor of abnormal misfolded protein species.
Externí odkaz:
https://doaj.org/article/2f78e00735454e27858d150cc64c59b9
Autor:
Hugo Fanlo-Ucar, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard ILL-Raga, Francisco J. Muñoz
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1208 (2024)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and it is currently the seventh leading cause of death worldwide. It is characterized by the extracellular aggregation of the amyloid β-peptide (Aβ) into oligomers and fibrils t
Externí odkaz:
https://doaj.org/article/8128c43c4f4b483a911efe7e1dbb65cb
Autor:
Pol Picón-Pagès, Jaume Bonet, Javier García-García, Joan Garcia-Buendia, Daniela Gutierrez, Javier Valle, Carmen E.S. Gómez-Casuso, Valeriya Sidelkivska, Alejandra Alvarez, Alex Perálvarez-Marín, Albert Suades, Xavier Fernàndez-Busquets, David Andreu, Rubén Vicente, Baldomero Oliva, Francisco J. Muñoz
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 963-971 (2019)
Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate into β-sheets that are n
Externí odkaz:
https://doaj.org/article/4d7969ee4d36414c870e199d21b5b7aa
Autor:
Juan A. Godoy, Juvenal A. Rios, Pol Picón-Pagès, Víctor Herrera-Fernández, Bronte Swaby, Giulia Crepin, Rubén Vicente, Jose M. Fernández-Fernández, Francisco J. Muñoz
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1012 (2021)
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is maintained by mitostasis, a pr
Externí odkaz:
https://doaj.org/article/a38e7543098540ffaef98974ca19ab6a
Autor:
Souha Hammouda, Imen Ghzaiel, Pol Picón-Pagès, Wiem Meddeb, Wided Khamlaoui, Sonia Hammami, Francisco J. Muñoz, Mohamed Hammami, Amira Zarrouk
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 797 (2021)
Oxysterols are assumed to be the driving force behind numerous neurodegenerative diseases. In this work, we aimed to study the ability of 7β-hydroxycholesterol (7β-OHC) to trigger oxidative stress and cell death in human neuroblastoma cells (SH-SY5
Externí odkaz:
https://doaj.org/article/274c340ce68948938660a1920c115d46
Autor:
Pol Picón-Pagès, Mònica Bosch-Morató, Laia Subirana, Francisca Rubio-Moscardó, Biuse Guivernau, Hugo Fanlo-Ucar, Melisa Ece Zeylan, Simge Senyuz, Víctor Herrera-Fernández, Rubén Vicente, José M. Fernández-Fernández, Jordi García-Ojalvo, Attila Gursoy, Ozlem Keskin, Baldomero Oliva, Francesc Posas, Eulàlia de Nadal, Francisco J. Muñoz
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1278
Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried out a genome-wide scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6643b7d527395618fc6b27e4f374f0
Autor:
Rubén Molina-Fernández, Pol Picón-Pagès, Alejandro Barranco-Almohalla, Giulia Crepin, Víctor Herrera-Fernández, Anna García-Elías, Hugo Fanlo-Ucar, Xavier Fernàndez-Busquets, Jordi García-Ojalvo, Baldomero Oliva, Francisco J Muñoz
Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first hallmarks of Type 2 diabetes). R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e753bc690dd37a4885f0b67b23c2f669
http://hdl.handle.net/10230/54779
http://hdl.handle.net/10230/54779
Autor:
Francisco J. Muñoz, Souha Hammouda, Sonia Hammami, Imen Ghzaiel, Amira Zarrouk, Wiem Meddeb, Wided Khamlaoui, Mohamed Hammami, Pol Picón-Pagès
Publikováno v:
Biomolecules
Volume 11
Issue 6
Biomolecules, Vol 11, Iss 797, p 797 (2021)
Volume 11
Issue 6
Biomolecules, Vol 11, Iss 797, p 797 (2021)
Oxysterols are assumed to be the driving force behind numerous neurodegenerative diseases. In this work, we aimed to study the ability of 7β-hydroxycholesterol (7β-OHC) to trigger oxidative stress and cell death in human neuroblastoma cells (SH-SY5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990911487bd1339d4daf3d4b530cf367
http://europepmc.org/articles/PMC8229989
http://europepmc.org/articles/PMC8229989
Autor:
Francisco J. Muñoz, Bronte Swaby, Juan A. Godoy, Víctor Herrera-Fernández, Juvenal A. Ríos, José M. Fernández-Fernández, Rubén Vicente, Pol Picón-Pagès, Giulia Crepin
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 1012, p 1012 (2021)
Biomolecules, Vol 11, Iss 1012, p 1012 (2021)
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is maintained by mitostasis, a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba53c2302d6b0db339fe192be171dbac
http://hdl.handle.net/10230/48327
http://hdl.handle.net/10230/48327
Autor:
Rubén Vicente, Alejandra R. Alvarez, Francisco J. Muñoz, Daniela A Gutiérrez, Pol Picón-Pagès, Montserrat Arumi-Uria, Marta Tajes, Gerard ILL-Raga, Silvia Menendez, Francesc X. Guix, Alejandro Barranco-Almohalla, Giulia Crepin
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
instname
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2c2683c4cef1d2bccafc4166a3cf4
http://hdl.handle.net/10261/233934
http://hdl.handle.net/10261/233934