Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pol Margalef"'
Autor:
Pol Margalef, Vanessa Fernández-Majada, Alberto Villanueva, Ricard Garcia-Carbonell, Mar Iglesias, Laura López, María Martínez-Iniesta, Jordi Villà-Freixa, Mari Carmen Mulero, Montserrat Andreu, Ferran Torres, Marty W. Mayo, Anna Bigas, Lluis Espinosa
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 840-854 (2012)
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains poorly understood. We hav
Externí odkaz:
https://doaj.org/article/e573cc73b601452a8359406a930971e0
Autor:
Roberto Bellelli, Simon J. Boulton, Harshil Patel, Anna R. Poetsch, Pol Margalef, Panagiotis Kotsantis, Graeme Hewitt, Sandra Segura-Bayona, Paulina Marzec, Phil Ruis, Robert L. Goldstone
Publikováno v:
SSRN Electronic Journal.
RTEL1 is an essential helicase that maintains telomere integrity and facilitates DNA replication. The source of replication stress in Rtel1 deficient cells remains unclear. Here, we report that loss of RTEL1 confers extensive transcriptional changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e090e5271de0087b140a9482374bbbb
https://doi.org/10.2139/ssrn.3639609
https://doi.org/10.2139/ssrn.3639609
Autor:
Pol Margalef, Anthony J. Cesare, Valerie Borel, Panagiotis Kotsantis, Dipanjan Chowdhury, Ambrosius P. Snijders, Grzegorz Sarek, Helen R. Flynn, David Van Ly, Phil Ruis, Simon J. Boulton, Xiaofeng Zheng
Publikováno v:
Nature
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76dc9c13f0a54e09659077d8c5a3823c
Autor:
Paulina Marzec, Anna R. Poetsch, Robert J. Goldstone, Simon J. Boulton, Graeme Hewitt, Roberto Bellelli, Sandra Segura-Bayona, Harshil Patel, Pol Margalef, Phil Ruis, Panagiotis Kotsantis
Publikováno v:
Cell Reports
Summary Regulator of telomere length 1 (RTEL1) is an essential helicase that maintains telomere integrity and facilitates DNA replication. The source of replication stress in Rtel1-deficient cells remains unclear. Here, we report that loss of RTEL1 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9f8f4cc74fa4af4560288a73504ced
https://doi.org/10.1016/j.celrep.2020.108546
https://doi.org/10.1016/j.celrep.2020.108546
Publikováno v:
Nature Structural & Molecular Biology. 22:867-874
Mutations in genes encoding proteins required for telomere structure, replication, repair and length maintenance are associated with several debilitating human genetic disorders. These complex telomere biology disorders (TBDs) give rise to critically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb25b712780806fd693cc8880e53730
https://doi.org/10.1038/nsmb.3093
https://doi.org/10.1038/nsmb.3093
Publikováno v:
British Journal of Cancer
Background: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. NF-κB signalling is a key ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cd7133d5bda0aea40677af41da9764
https://pubmed.ncbi.nlm.nih.gov/29438366
https://pubmed.ncbi.nlm.nih.gov/29438366
Autor:
Stephanie Panier, Roberto Bellelli, Panagiotis Kotsantis, Pol Margalef, Simon J. Boulton, Valerie Borel
Publikováno v:
Cell
Telomere maintenance critically depends on the distinct activities of telomerase, which adds telomeric repeats to solve the end replication problem, and RTEL1, which dismantles DNA secondary structures at telomeres to facilitate replisome progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0f6a66f7d317259cfa2b63f3550496
https://pubmed.ncbi.nlm.nih.gov/29408234
https://pubmed.ncbi.nlm.nih.gov/29408234
Autor:
Lluis Espinosa, Emili Masferrer, Carla Ferrándiz-Pulido, Ramon M. Pujol, Javier Gimeno, Anna Bigas, Agustí Toll, Pol Margalef
Publikováno v:
Archives of dermatological research. 307(8)
About 5 % of all cutaneous squamous cell carcinomas (cSCCs) metastasize, which is the principal cause of death by this type of cancer. However, to date there are no reliable biomarkers that categorize those SCC patients that will progress to metastas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a1c6074eca32cab880e447e1025201
https://pubmed.ncbi.nlm.nih.gov/26094020
https://pubmed.ncbi.nlm.nih.gov/26094020
Publikováno v:
Nature Structural & Molecular Biology. 24:553-553
Nat. Struct. Mol. Biol. 22, 867–874 (2015); published online 4 November 2015; corrected after print 20 April 2017 The schematic of the TERT subunit in Figure 1 incorrectly identified the 'Internal RNA template': it now correctly indicates the telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fde1879af38f11d9f5ebde19da9d161
https://doi.org/10.1038/nsmb0617-553a
https://doi.org/10.1038/nsmb0617-553a
Autor:
Pol Margalef, Elena Asensio-Juan, Verónica Rodilla, Nuria Lopez-Bigas, Matteo Pecoraro, Luciano Di Croce, Erika López-Arribillaga, M. Mar Albà, William M. Keyes, Jordi Villà-Freixa, Shelly M. Davis, Lluis Espinosa, Mar Iglesias, Agustí Toll, Anna Bigas, Nils J. D. Drechsel, Dolors Ferres-Marco, Nicolás Bellora, Abul B. M. M. K. Islam, Jessica González, Alexander Hoffmann, Fernando Gallardo, Cristina Charneco, María Teresa Domínguez, Maria Carmen Mulero, Vincent Feng-Sheng Shih, Shigeki Miyamoto
Publikováno v:
RIUVic. Repositorio Institucional de la Universidad de Vic
instname
Cancer cell, vol 24, iss 2
Recercat. Dipósit de la Recerca de Catalunya
instname
Cancer cell, vol 24, iss 2
Recercat. Dipósit de la Recerca de Catalunya
IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836795346f57a5457e92d6ef7faa4be3
http://hdl.handle.net/10261/289032
http://hdl.handle.net/10261/289032
