Zobrazeno 1 - 10
of 1 571
pro vyhledávání: '"Pol II"'
Autor:
Raul Riera Aroche, Yveth M. Ortiz García, Esli C. Sánchez Moreno, José S. Enriquez Cervantes, Andrea C. Machado Sulbaran, Annie Riera Leal
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12152-12173 (2024)
Previously, we described that Adenine, Thymine, Cytosine, and Guanine nucleobases were superconductors in a quantum superposition of phases on each side of the central hydrogen bond acting as a Josephson Junction. Genomic DNA has two strands wrapped
Externí odkaz:
https://doaj.org/article/e572f92189144dcab892bc4177f7b95b
Autor:
Patricia Rojas, Jianming Wang, Giovanni Guglielmi, Martina Mustè Sadurnì, Lucas Pavlou, Geoffrey Ho Duen Leung, Vijay Rajagopal, Fabian Spill, Marco Saponaro
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background DNA replication progression can be affected by the presence of physical barriers like the RNA polymerases, leading to replication stress and DNA damage. Nonetheless, we do not know how transcription influences overall DNA replicat
Externí odkaz:
https://doaj.org/article/072a3bf961d1417a9d243d2700149b95
Publikováno v:
eLife, Vol 12 (2024)
In insects and mammals, 3D genome topology has been linked to transcriptional states yet whether this link holds for other eukaryotes is unclear. Using both ligation proximity and fluorescence microscopy assays, we show that in Saccharomyces cerevisi
Externí odkaz:
https://doaj.org/article/56f3a911554a435cbd94a079c9b4cbfa
Autor:
Hongyu Luo, Linjiang Lao, Kit Sing Au, Hope Northrup, Xiao He, Diane Forget, Marie-Soleil Gauthier, Benoit Coulombe, Isabelle Bourdeau, Wei Shi, Lucia Gagliardi, Maria Candida Barisson Villares Fragoso, Junzheng Peng, Jiangping Wu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-42 (2024)
Abstract Background Neural tube defects (NTDs) are caused by genetic and environmental factors. ARMC5 is part of a novel ubiquitin ligase specific for POLR2A, the largest subunit of RNA polymerase II (Pol II). Results We find that ARMC5 knockout mice
Externí odkaz:
https://doaj.org/article/5dba6e1a966c401b883f1f1b4da5dd56
Lowering mutant huntingtin by small molecules relieves Huntington’s disease symptoms and progression
Autor:
Anat Bahat, Elad Itzhaki, Benjamin Weiss, Michael Tolmasov, Michael Tsoory, Yael Kuperman, Alexander Brandis, Khriesto A Shurrush, Rivka Dikstein
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 523-546 (2024)
Abstract Huntington’s disease (HD) is an incurable inherited disorder caused by a repeated expansion of glutamines in the huntingtin gene (Htt). The mutant protein causes neuronal degeneration leading to severe motor and psychological symptoms. Sel
Externí odkaz:
https://doaj.org/article/daf1c01894994b038bafadb5ab746255
Publikováno v:
Cells, Vol 13, Iss 21, p 1782 (2024)
CRISPR/Cas9 is a powerful genome editing tool for trait improvement in various crops; however, enhancing mutation efficiency using CRISPR/Cas9 in watermelon and melon remains challenging. We designed four CRISPR systems with different sgRNA expressio
Externí odkaz:
https://doaj.org/article/eeecb134505247608a614bd8a64724f7
Akademický článek
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Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background In Arabidopsis, RNA Polymerase II (Pol II) often pauses within a few hundred base pairs downstream of the polyadenylation site, reflecting efficient transcriptional termination, but how such pausing is regulated remains largely el
Externí odkaz:
https://doaj.org/article/b9be2a2bba0c4921a3270b52c0e1cadd
Autor:
Martina Muste Sadurni, Marco Saponaro
Publikováno v:
Applied Biosciences, Vol 2, Iss 3, Pp 459-476 (2023)
Deregulated transcription is a well-known characteristic of cancer cells, with differentially expressed genes being a common feature of several cancers. Often, deregulated transcription is a consequence of alterations in transcription factors (TFs),
Externí odkaz:
https://doaj.org/article/f8c0934d247a4455a935c06ce4a1edef
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects high
Externí odkaz:
https://doaj.org/article/2ac32dbd477c4ebc93c9a44112e5308c