Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers

Autor: Man Wu, Pok Man Hau, Linxian Li, Chi Man Tsang, Yike Yang, Aziz Taghbalout, Grace Tin-Yun Chung, Shin Yee Hui, Wing Chung Tang, Nathaniel Jillette, Jacqueline Jufen Zhu, Horace Hok Yeung Lee, Ee Ling Kong, Melissa Sue Ann Chan, Jason Ying Kuen Chan, Brigette Buig Yue Ma, Mei-Ru Chen, Charles Lee, Ka Fai To, Albert Wu Cheng, Kwok-Wai Lo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract The unique virus-cell interaction in Epstein-Barr virus (EBV)-associated malignancies implies targeting the viral latent-lytic switch is a promising therapeutic strategy. However, the lack of specific and efficient therapeutic agents to indu

Externí odkaz: https://doaj.org/article/5ea7e874509d4bf389c2b2f00f71f2fc

Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study.

Autor: Yim Ling Yip, Pei Shin Pang, Wen Deng, Chi Man Tsang, Musheng Zeng, Pok Man Hau, Cornelia Man, Yuesheng Jin, Anthony Po Wing Yuen, Sai Wah Tsao

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78395 (2013)

Nasopharyngeal carcinoma (NPC) is common among southern Chinese including the ethnic Cantonese population living in Hong Kong. Epstein-Barr virus (EBV) infection is detected in all undifferentiated type of NPC in this endemic region. Establishment of

Externí odkaz: https://doaj.org/article/3c3ef5a36efa435f879f692672bdc6a7

EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma

Autor: Lee Fah Yap, Anthony Wh Chan, Ken H-O Yu, Pok Man Hau, Ka-Hei Lam, Kevin Y. Yip, Philippe Busson, Jesse C-S Pang, Joanna Hm Tong, Angela K. F. Lo, Shuk-Ling Chau, Johnny S-H Kwan, Edith K. Y. Tin, Wing-Po Chak, Sai Wah Tsao, Raymond Wm Lung, Kwok Wai Lo, Ka Fai To, Lawrence S. Young

Publikováno v: The Journal of Pathology. 244:394-407

Nasopharyngeal carcinoma (NPC) is a highly invasive epithelial malignancy that is prevalent in southern China and Southeast Asia. It is consistently associated with latent Epstein-Barr virus (EBV) infection. In NPC, miR-BARTs, the EBV-encoded miRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c57d52156a3c9267b020784f1d470a2
https://doi.org/10.1002/path.5018

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

Autor: Xuefeng Liu, Grace Tin Yun Chung, Kwai Fung Hui, Chi Keung Chan, Annie L.M. Cheung, Bin Li, Jimmy Yu Wai Chan, Kevin Y. Yip, Sai Wah Tsao, Pok Man Hau, Dora Lai-Wan Kwong, Weitao Lin, Yuk Chun Cheung, Jaap M. Middeldorp, Yim Ling Yip, Yuan Zhou, Tengfei Liu, Wei Dai, Wen Deng, Kwok Wai Lo, Jun Zhang, Maria Li Lung, Lin Jia, Josephine Mun Yee Ko, Sau Dan Lee, Victor Ho-Fun Lee, Johnny S. H. Kwan, John M. Nicholls, Siu Tim Cheung, Alan K. S. Chiang, Chi Man Tsang, Philippe Busson, Honglin Chen, H Kwok, Hong Zheng

Publikováno v: Lin, W, Yip, Y L, Jia, L, Deng, W, Zheng, H, Dai, W, Ko, J M Y, Lo, K W, Chung, G T Y, Yip, K Y, Lee, S-D, Kwan, J S-H, Zhang, J, Liu, T, Chan, J Y-W, Kwong, D L-W, Lee, V H-F, Nicholls, J M, Busson, P, Liu, X, Chiang, A K S, Hui, K F, Kwok, H, Cheung, S T, Cheung, Y C, Chan, C K, Li, B, Cheung, A L-M, Hau, P M, Zhou, Y, Tsang, C M, Middeldorp, J, Chen, H, Lung, M L & Tsao, S W 2018, ' Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma ', Nature Communications, vol. 9, no. 1, 4663 . https://doi.org/10.1038/s41467-018-06889-5
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications, 9(1):4663. Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

The lack of representative nasopharyngeal carcinoma (NPC) models has seriously hampered research on EBV carcinogenesis and preclinical studies in NPC. Here we report the successful growth of five NPC patient-derived xenografts (PDXs) from fifty-eight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb3c60b87de21a97b858e4aa734270a
https://doi.org/10.1038/s41467-018-06889-5

Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells

Autor: Pok Man Hau, Vivian Wai Yan Lui, Yim Ling Yip, Mu Sheng Zeng, Chi Man Tsang, Wen Deng, Annie L.M. Cheung, Kenzo Takada, Victoria Ming Yi Lau, Honglin Chen, Sai Wah Tsao, Kwok Wai Lo, Ka Fai To, Jaap M. Middeldorp, Maria Li Lung

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 109(50), E3473-E3482. National Academy of Sciences
Tsang, C M, Yip, Y L, Lo, K W, Deng, W, To, K F, Hau, P M, Lau, V M Y, Takada, K, Lui, V W Y, Lung, M L, Chen, H, Zeng, M, Middeldorp, J M, Cheung, A L M & Tsao, S W 2012, ' Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells ', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 50, pp. E3473-E3482 . https://doi.org/10.1073/pnas.1202637109

Undifferentiated nasopharyngeal carcinomas (NPCs) are commonly present with latent EBV infection. However, events regulating EBV infection at early stages of the disease and the role of EBV in disease pathogenesis are largely undefined. Genetic alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6796680643963ff510fd2d7b5e3ed302