E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms.

Autor: Peters CH; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO., Watkins AR; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Poirier OL; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Ruben PC; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2020 Sep 07; Vol. 152 (9).