Zobrazeno 1 - 10
of 7 739
pro vyhledávání: '"Point mutations"'
Autor:
Anselmo Vasconcelos Rivetti, Jr., Dilmara Reischak, Cairo Henrique Sousa de Oliveira, Juliana Nabuco Pereira Otaka, Christian Steffe Domingues, Talita de Lima Freitas, Fernanda Gomes Cardoso, Lucas Oliveira Montesino, Ana Luiza Savioli da Silva, Soraya Cecília Albieri Camillo, Fernanda Malta, Deyvid Amgarten, Aristóteles Goés-Neto, Eric Roberto Guimarães Rocha Aguiar, Iassudara Garcia de Almeida, Carla Amaral Pinto, Antônio Augusto Fonseca, Jr, Marcelo Fernandes Camargos
Publikováno v:
Virus Research, Vol 347, Iss , Pp 199415- (2024)
Our study identified strains of the A/H5N1 virus in analyzed samples of subsistence poultry, wild birds, and mammals, belonging to clade 2.3.4.4b, genotype B3.2, with very high genetic similarity to strains from Chile, Uruguay, and Argentina. This su
Externí odkaz:
https://doaj.org/article/c4fa0c6c2eac45788c0a7e329022177f
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 945-951 (2024)
Hearing loss constitutes one of the most prevalent conditions within the field of otolaryngology. Recent investigations have revealed that mutations in deafness-associated genes, including point mutations and variations in DNA sequences, can cause he
Externí odkaz:
https://doaj.org/article/899919621de74b84826eb01554750298
Assessing the reliability of point mutation as data augmentation for deep learning with genomic data
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Deep neural networks (DNNs) have the potential to revolutionize our understanding and treatment of genetic diseases. An inherent limitation of deep neural networks, however, is their high demand for data during training. To overco
Externí odkaz:
https://doaj.org/article/979cd6ed040146ed80923cd0aca97af4
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10260 (2024)
Human serum albumin (HSA) is an endogenous inhibitor of angiotensin I-converting enzyme (ACE) and, thus, plays a key role in the renin–angiotensin–aldosterone system (RAAS). However, little is known about the mechanism of interaction between thes
Externí odkaz:
https://doaj.org/article/885f4ada70fb4c469908adf26d81d800
Autor:
Sravani Akula, Sai Charitha Mullaguri, Niklas Max Melton, Archana Katta, Venkata Sai Giridhar Reddy Naga, Shyamson Kandula, Raj Kumar Pedada, Janakiraman Subramanian, Rama Krishna Kancha
Publikováno v:
Cancer Medicine, Vol 12, Iss 16, Pp 17468-17474 (2023)
Abstract Background Mutations in kinases are the most frequent genetic alterations in cancer; however, experimental evidence establishing their cancerous nature is available only for a small fraction of these mutants. Aims Predicition analysis of kin
Externí odkaz:
https://doaj.org/article/e7fbbda0df94487197d9dc00e823a0e8
Autor:
Selene Cipri, Francesco Fabozzi, Giada Del Baldo, Giuseppe Maria Milano, Luigi Boccuto, Andrea Carai, Angela Mastronuzzi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The family of the neurotrophic tyrosine kinase receptor (NTRK) gene encodes for members of the tropomyosin receptor kinase (TRK) family. Rearrangements involving NTRK1/2/3 are rare oncogenic factors reported with variable frequencies in an extensive
Externí odkaz:
https://doaj.org/article/cf10beb382ba46aeafc72aef2a0d4839
Publikováno v:
Journal of Fungi, Vol 10, Iss 4, p 261 (2024)
The necrotrophic pathogen Botrytis cinerea infects a broad range of plant hosts and causes substantial economic losses to many crops. Although resistance to procymidone has been observed in the field, it remains uncertain why procymidone is usually i
Externí odkaz:
https://doaj.org/article/de88764b9b4f4226b2e834b8c6ec3ebc
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Genome editing using CRISPR/Cas9 has become a powerful tool in zebrafish to generate targeted gene knockouts models. However, its use for targeted knock-in remains challenging due to inefficient homology directed repair (HDR) path
Externí odkaz:
https://doaj.org/article/3832feaabff945a09e26b9f89b2e9c43
Publikováno v:
Molecules, Vol 29, Iss 4, p 881 (2024)
The major histocompatibility complex (MHC) can recognize and bind to external peptides to generate effective immune responses by presenting the peptides to T cells. Therefore, understanding the binding modes of peptide–MHC complexes (pMHC) and pred
Externí odkaz:
https://doaj.org/article/150b68b5f3fd4f7eaa79d0443bf911ea
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2174 (2024)
The contagiousness of SARS-CoV-2 β-coronavirus is determined by the virus–receptor electrostatic association of its positively charged spike (S) protein with the negatively charged angiotensin converting enzyme-2 (ACE2 receptor) of the epithelial
Externí odkaz:
https://doaj.org/article/b04204d6b4a049deaa0b1d3fd8f17a6c