A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.

Autor: Thomas T; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Friedrich M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Rich-Griffin C; Centre for Human Genetics, University of Oxford, Oxford, UK., Pohin M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Agarwal D; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Pakpoor J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Lee C; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Tandon R; University College London Hospitals NHS Foundation Trust, London, UK., Rendek A; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Aschenbrenner D; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Jainarayanan A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Voda A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Siu JHY; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sanches-Peres R; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Nee E; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sathananthan D; University of Adelaide, Adelaide, Australia.; Lyell McEwin Hospital, Adelaide, Australia., Kotliar D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Todd P; Centre for Human Genetics, University of Oxford, Oxford, UK., Kiourlappou M; Centre for Human Genetics, University of Oxford, Oxford, UK., Gartner L; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Ilott N; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Issa F; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Turner J; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Nayar S; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and NIHR Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Mackerodt J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Zhang F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Center for Health AI, University of Colorado Anschutz, Anschutz, CO, USA., Jonsson A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Brenner M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Raychaudhuri S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kulicke R; Celsius Therapeutics, Cambridge, MA, USA., Ramsdell D; Celsius Therapeutics, Cambridge, MA, USA., Stransky N; Celsius Therapeutics, Cambridge, MA, USA., Pagliarini R; Celsius Therapeutics, Cambridge, MA, USA., Bielecki P; Celsius Therapeutics, Cambridge, MA, USA., Spies N; Celsius Therapeutics, Cambridge, MA, USA., Marsden B; Centre for Human Genetics, University of Oxford, Oxford, UK., Taylor S; Centre for Human Genetics, University of Oxford, Oxford, UK., Wagner A; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, USA.; The Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Klenerman P; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Walsh A; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Coles M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Jostins-Dean L; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Filer A; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and NIHR Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Travis S; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. simon.travis@kennedy.ox.ac.uk.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. simon.travis@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. simon.travis@kennedy.ox.ac.uk., Uhlig HH; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; Department of Paediatrics, University of Oxford, Oxford, UK. holm.uhlig@ndm.ox.ac.uk., Dendrou CA; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.; Centre for Human Genetics, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk., Buckley CD; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. christopher.buckley@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.

Publikováno v: Nature immunology [Nat Immunol] 2024 Nov; Vol. 25 (11), pp. 2152-2165. Date of Electronic Publication: 2024 Oct 22.

Role of autophagy in immune aging

Autor: Richter, F, Friedrich, M, Alsaleh, G, Pohin, M, Wideman, S, Schipper, H, Edwards, C, Powrie, F, Simon, AK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::e2297e338184b05b97100bc52fdbb5a1
https://doi.org/10.1002/eji.202170200

Cell-extrinsic autophagy in mature adipocytes regulates anti-inflammatory response to intestinal tissue injury through lipid mobilization

Autor: Richter, FC, Friedrich, M, Pohin, M, Alsaleh, G, Guschina, I, Wideman, SK, Johnson, E, Borsa, M, Piletic, K, Hahn, P, Schipper, HS, Edwards, CM, Powrie, F, Simon, AK

Autophagy is a critical cellular recycling pathway which is genetically linked to the development of intestinal inflammation in humans. Inflammation drives adipose tissue breakdown and provision of major nutrients such as free fatty acids (FFA). Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::284ebe8adae1db6d0bc095229a110a31
https://doi.org/10.1101/2021.10.25.465200

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.

Autor: Korsunsky I; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Pohin M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK., Kim EY; Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Barone F; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK., Major T; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; Birmingham Tissue Analytics, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK., Taylor E; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; Birmingham Tissue Analytics, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK., Ravindran R; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK., Kemble S; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK., Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Jeong Y; Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Athar H; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Windell D; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK., Kang JB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA., Friedrich M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK., Turner J; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; Birmingham Tissue Analytics, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK., Nayar S; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; Birmingham Tissue Analytics, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TT, UK., Fisher BA; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TT, UK., Raza K; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TT, UK., Marshall JL; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK., Croft AP; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK., Tamura T; Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Sholl LM; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Vivero M; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Rosas IO; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Dallas, TX 75246, USA., Bowman SJ; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TT, UK., Coles M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK., Frei AP; Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel 4070, Switzerland., Lassen K; Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel 4070, Switzerland., Filer A; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; Birmingham Tissue Analytics, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TT, UK., Powrie F; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK. Electronic address: fiona.powrie@kennedy.ox.ac.uk., Buckley CD; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, UK; Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, UK; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TT, UK. Electronic address: christopher.buckley@kennedy.ox.ac.uk., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: mbrenner@research.bwh.harvard.edu., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester M14 9PR UK. Electronic address: soumya@broadinstitute.org.

Publikováno v: Med (New York, N.Y.) [Med] 2022 Jul 08; Vol. 3 (7), pp. 481-518.e14. Date of Electronic Publication: 2022 May 31.

IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.

Autor: Friedrich M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Pohin M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Jackson MA; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Bullers SJ; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rue-Albrecht K; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Christoforidou Z; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Sathananthan D; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Thomas T; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Ravindran R; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Tandon R; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Peres RS; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Sharpe H; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wei K; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Watts GFM; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mann EH; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Geremia A; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Attar M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., McCuaig S; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Thomas L; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Collantes E; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Uhlig HH; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.; Department of Paediatrics, John Radcliffe Hospital, Oxford, UK., Sansom SN; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Easton A; Old Road Campus Research Building, Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Travis SP; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Powrie FM; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. fiona.powrie@kennedy.ox.ac.uk.

Publikováno v: Nature medicine [Nat Med] 2021 Nov; Vol. 27 (11), pp. 1970-1981. Date of Electronic Publication: 2021 Oct 21.