Dengue and Zika RNA-RNA interactomes reveal pro- and anti-viral RNA in human cells.

Autor: Liao KC; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore., Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA., Sundstrom AKB; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore., Lim XN; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore., Tan KK; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore., Zhang Y; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore., Zou J; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA., Bifani AM; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore., Poh HX; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore., Chen JJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Ng WC; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore., Lim SY; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore., Ooi EE; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore., Sessions OM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore.; Department of Pharmacy, National University of Singapore, Singapore, 117559, Singapore., Tay Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA. peshi@utmb.edu., Huber RG; Biomolecular Function Discovery, Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Matrix #07-01, Singapore, 138671, Singapore. rghuber@bii.a-star.edu.sg., Wan Y; Stem Cell and Regenerative Biology, Genome Institute of Singapore, Singapore, 138672, Singapore. wany@gis.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. wany@gis.a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. wany@gis.a-star.edu.sg.

Publikováno v: Genome biology [Genome Biol] 2023 Dec 05; Vol. 24 (1), pp. 279. Date of Electronic Publication: 2023 Dec 05.

BTG1 mutation yields supercompetitive B cells primed for malignant transformation.

Autor: Mlynarczyk C; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Teater M; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Pae J; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Chin CR; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Tri-Institutional PhD Program in Computational Biomedicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Wang L; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Arulraj T; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany., Barisic D; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Papin A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Hoehn KB; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Kots E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Ersching J; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Bandyopadhyay A; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany., Barin E; Department of Pharmacology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Poh HX; Department of Pharmacology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Evans CM; Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Chadburn A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Chen Z; Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA., Shen H; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Isles HM; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Pelzer B; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Tsialta I; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Doane AS; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Geng H; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Rehman MH; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medicine-Qatar, Doha, Qatar., Melnick J; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Morgan W; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Nguyen DTT; Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine and Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Kharas MG; Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jaffrey SR; Department of Pharmacology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Scott DW; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Khelashvili G; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Meyer-Hermann M; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany.; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany., Victora GD; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Melnick A; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Jan 20; Vol. 379 (6629), pp. eabj7412. Date of Electronic Publication: 2023 Jan 20.

The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.

Autor: Dixit D; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Prager BC; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio., Gimple RC; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio., Poh HX; Department of Pharmacology, Weill Cornell Medicine, New York, New York., Wang Y; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California., Wu Q; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Qiu Z; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Kidwell RL; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Kim LJY; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio., Xie Q; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Vitting-Seerup K; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Bhargava S; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Dong Z; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Jiang L; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Zhu Z; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California., Hamerlik P; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Jaffrey SR; Department of Pharmacology, Weill Cornell Medicine, New York, New York., Zhao JC; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. drjeremyrich@gmail.com xiuxingwang81@163.com czhao@sbpdiscovery.org., Wang X; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California. drjeremyrich@gmail.com xiuxingwang81@163.com czhao@sbpdiscovery.org., Rich JN; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, California. drjeremyrich@gmail.com xiuxingwang81@163.com czhao@sbpdiscovery.org.; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA; UPMC Hillman Cancer Center, Pittsburgh, PA.

Publikováno v: Cancer discovery [Cancer Discov] 2021 Feb; Vol. 11 (2), pp. 480-499. Date of Electronic Publication: 2020 Oct 06.