Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Poguang Wang"'
Autor:
Elisabeth Roider, Alexandra I. T. Lakatos, Alicia M. McConnell, Poguang Wang, Alina Mueller, Akinori Kawakami, Jennifer Tsoi, Botond L. Szabolcs, Anna A. Ascsillán, Yusuke Suita, Vivien Igras, Jennifer A. Lo, Jennifer J. Hsiao, Rebecca Lapides, Dorottya M. P. Pál, Anna S. Lengyel, Alexander Navarini, Arimichi Okazaki, Othon Iliopoulos, István Németh, Thomas G. Graeber, Leonard Zon, Roger W. Giese, Lajos V. Kemeny, David E. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis. MITF genomic amplification promotes melanoma development, and it can facil
Externí odkaz:
https://doaj.org/article/cc94d2d3111647cfb25391c16c6a03e3
Publikováno v:
Rapid Commun Mass Spectrom
RATIONALE: We studied an aldehyde-labeling reagent, N-{2-[(4-aminophenoxy)methyl]benzyl}-N,N-diethylethanaminium bromide (CAX-A), containing an aniline functional group, for the detection of aldehydes with high specificity. METHODS: Six standard alde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4702b319d298f088e586c4f8496827
https://doi.org/10.1002/rcm.9322
https://doi.org/10.1002/rcm.9322
Autor:
Poguang Wang, Roger W. Giese, Caitlin Kramer, Gunjan L. Shah, Elisabeth Roider, Heather Landau, Michael E. Coulter, Christopher A. Walsh, Penny J. Beuning
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:1641-1646
While MALDI-MS of intact genomic DNA is unheard of, actually many DNA adducts can be detected in this way under certain MALDI conditions: relatively high molar ratio of DNA nucleobases to matrix (0.01 to 0.3), hot matrix (CCA), and high laser fluence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ee6bf5d78b088e5ed6cd6d851cf5f0
https://doi.org/10.1021/jasms.0c00084
https://doi.org/10.1021/jasms.0c00084
Autor:
Poguang Wang, Caitlin Kramer, Roger W. Giese, Elisabeth Roider, Michael E. Coulter, Christopher A. Walsh, Penny J. Beuning
Publikováno v:
Rapid Communications in Mass Spectrometry. 35
RATIONALE As a new approach to DNA adductomics, we directly reacted intact, double-stranded (ds)-DNA under warm conditions with an alkylating mass tag followed by analysis by liquid chromatography/mass spectrometry. This method is based on the tenden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe2230c1cdf1e0dd2d648a62e8e4011
https://doi.org/10.1002/rcm.9095
https://doi.org/10.1002/rcm.9095
Nontargeted analysis of the urine nonpolar sulfateome: a pathway to the nonpolar xenobiotic exposome
Autor:
Liza V. Anzalota Del Toro, Jose Codero, Poguang Wang, Gang Shao, Yuanyuan Yao, Roger W. Giese
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:2341-2350
Rationale Testing the urine nonpolar sulfateome can enable discovery of xenobiotics that are most likely to be bioactive. This is based on the fact that nonpolar xenobiotics are more likely to enter cells where they tend to undergo metabolism, in par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fefe152ca9caee088e3ce5f7f68c677
https://doi.org/10.1002/rcm.7726
https://doi.org/10.1002/rcm.7726
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:653-661
RATIONALE Phenols are an important class of analytes, for example as bioactive environmental contaminants. Towards a goal of improving their detection by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) or M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75bc2df76847919f2f713e6cba6026e
https://doi.org/10.1002/rcm.6816
https://doi.org/10.1002/rcm.6816
Autor:
Poguang Wang, Roger W. Giese
Publikováno v:
Chemical Research in Toxicology. 31:1106-1107
Platinum chemotherapeutic agents have been widely used in the treatment of cancer. Cisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dae19495c10b39fd98abf603ce2b4d
https://doi.org/10.1021/acs.chemrestox.8b00134
https://doi.org/10.1021/acs.chemrestox.8b00134
Autor:
Caitlin Sarubbi, Poguang Wang, David J. Chung, Dean Carlow, Heather Landau, Valkal Bhatt, Gunjan L. Shah, Sean M. Devlin, Ryan Schofield, Parastoo B. Dahi, Roger W. Giese, Elizabeth Hoover, Guenther Koehne, Andrew Lin, Roni Tamari, Stephen Harnicar, Sergio Giralt, Elaina V. Preston
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S129-S130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f76bf833a1f1a0d735cc9157b9cdaa
https://doi.org/10.1016/j.bbmt.2017.12.072
https://doi.org/10.1016/j.bbmt.2017.12.072
Publikováno v:
Chemical Research in Toxicology. 26:1424-1429
We investigate the limit of detection for obtaining NMR data of a DNA adduct using modern microscale NMR instrumentation, once the adduct has been isolated at the picomole level. Eighty nanograms (130 pmol) of a DNA adduct standard, N-(2′-deoxyguan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c41e23cd53fe66af852775d049575645
https://doi.org/10.1021/tx400051j
https://doi.org/10.1021/tx400051j
Autor:
Roger W. Giese, Poguang Wang
Publikováno v:
Journal of chromatography. A. 1486
Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) has been used for quantitative analysis of small molecules for many years. It is usually preceded by an LC separation step when complex samples are tested. With the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff4703212ce6169eca647350bb3587c
https://pubmed.ncbi.nlm.nih.gov/28118972
https://pubmed.ncbi.nlm.nih.gov/28118972