MethylGPT: a foundation model for the DNA methylome.

Autor: Ying K, Song J, Cui H, Zhang Y, Li S, Chen X, Liu H, Eames A, McCartney DL, Marioni RE, Poganik JR, Moqri M, Wang B, Gladyshev VN

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

Challenges and recommendations for the translation of biomarkers of aging.

Autor: Herzog CMS; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria., Goeminne LJE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Poganik JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Barzilai N; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA., Belsky DW; Department of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA., Betts-LaCroix J; Retro Biosciences, Inc, San Francisco, CA, USA., Chen BH; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA., Chen M; Insilico Medicine, Cambridge, MA, USA., Cohen AA; Department of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA., Cummings SR; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA., Fedichev PO; Gero PTE Ltd, Singapore, Singapore., Ferrucci L; National Institute on Aging, Baltimore, MD, USA., Fleming A; Kinexum LLC, Harpers Ferry, WV, USA., Fortney K; BioAge Labs, Richmond, CA, USA., Furman D; Buck Institute for Research on Aging, Novato, CA, USA.; Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA.; The National Scientific and Research Council, Austral University, Buenos Aires, Argentina., Gorbunova V; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Higgins-Chen A; Department of Psychiatry, Yale University, New Haven, CT, USA., Hood L; Buck Institute for Research on Aging, Novato, CA, USA.; Phenome Health, Seattle, WA, USA., Horvath S; Altos Labs, San Diego, CA, USA., Justice JN; XPRIZE Foundation, Culver City, CA, USA.; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Kiel DP; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Kuchel GA; University of Connecticut School of Medicine, @UConnAging, Farmington, CT, USA., Lasky-Su J; Department of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., LeBrasseur NK; Department of Physical Medicine and Rehabilitation, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Maier AB; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore.; Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Schilling B; Buck Institute for Research on Aging, Novato, CA, USA., Sebastiano V; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA., Slagboom PE; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Snyder MP; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA, USA., Widschwendter M; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Department of Women's Cancer, EGA Institute for Women's Health, University College London, London, UK.; Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden., Zhavoronkov A; Insilico Medicine, Cambridge, MA, USA., Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mmoqri@bwh.harvard.edu.; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA. mmoqri@bwh.harvard.edu., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@rics.bwh.harvard.edu.

Publikováno v: Nature aging [Nat Aging] 2024 Oct; Vol. 4 (10), pp. 1372-1383. Date of Electronic Publication: 2024 Sep 16.

TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.

Autor: Griffin PT; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Kane AE; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA.; Institute for Systems Biology, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Trapp A; Brigham and Women's Hospital, Division of Genetics, Department of Medicine, Harvard Medical School, Boston, MA, USA., Li J; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Arnold M; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Poganik JR; Brigham and Women's Hospital, Division of Genetics, Department of Medicine, Harvard Medical School, Boston, MA, USA., Conway RJ; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., McNamara MS; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Meer MV; Brigham and Women's Hospital, Division of Genetics, Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; San Diego Institute of Science, Altos Labs, San Diego, CA, USA., Hoffman N; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Amorim JA; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Tian X; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., MacArthur MR; Department of Health Sciences and Technology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA., Mitchell SJ; Department of Health Sciences and Technology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland.; Ludwig Princeton Branch, Princeton University, Princeton, NJ, USA., Mueller AL; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA.; Cell Metabolism, Cell Press, Cambridge, MA, USA., Carmody C; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Vera DL; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA., Kerepesi C; Brigham and Women's Hospital, Division of Genetics, Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Computer Science and Control, Eötvös Loránd Research Network, Budapest, Hungary., Ying K; Brigham and Women's Hospital, Division of Genetics, Department of Medicine, Harvard Medical School, Boston, MA, USA., Noren Hooten N; Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Mitchell JR; Department of Health Sciences and Technology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Gladyshev VN; Brigham and Women's Hospital, Division of Genetics, Department of Medicine, Harvard Medical School, Boston, MA, USA., Sinclair DA; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA, USA. david_sinclair@hms.harvard.edu.

Publikováno v: Nature aging [Nat Aging] 2024 Feb; Vol. 4 (2), pp. 261-274. Date of Electronic Publication: 2024 Jan 10.

Author Correction: Universal DNA methylation age across mammalian tissues.

Autor: Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Altos Labs, San Diego Institute of Science, San Diego, CA, USA., Fei Z; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Statistics, University of California, Riverside, Riverside, CA, USA., Haghani A; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Altos Labs, San Diego Institute of Science, San Diego, CA, USA., Robeck TR; Zoological SeaWorld Parks and Entertainment, Orlando, FL, USA., Zoller JA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA., Li CZ; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA., Lowe R; Altos Labs, Cambridge Institute of Science, Cambridge, UK., Yan Q; Altos Labs, San Diego Institute of Science, San Diego, CA, USA., Zhang J; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Vu H; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Ablaeva J; Department of Biology, University of Rochester, Rochester, NY, USA., Acosta-Rodriguez VA; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Adams DM; Department of Biology, University of Maryland, College Park, MD, USA., Almunia J; Loro Parque Fundacion, Puerto de la Cruz, Spain., Aloysius A; Department of Biology, University of Kentucky, Lexington, KY, USA., Ardehali R; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Arneson A; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Baker CS; Marine Mammal Institute, Oregon State University, Newport, OR, USA., Banks G; School of Science and Technology, Clifton Campus, Nottingham Trent University, Nottingham, UK., Belov K; School of Life and Environmental Sciences, the University of Sydney, Sydney, New South Wales, Australia., Bennett NC; Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa., Black P; Busch Gardens Tampa, Tampa, FL, USA., Blumstein DT; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, USA.; Rocky Mountain Biological Laboratory, Crested Butte, CO, USA., Bors EK; Marine Mammal Institute, Oregon State University, Newport, OR, USA., Breeze CE; Altius Institute for Biomedical Sciences, Seattle, WA, USA., Brooke RT; Epigenetic Clock Development Foundation, Los Angeles, CA, USA., Brown JL; Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA, USA., Carter GG; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA., Caulton A; AgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand.; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Cavin JM; Gulf World, Dolphin Company, Panama City Beach, FL, USA., Chakrabarti L; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK., Chatzistamou I; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC, USA., Chen H; Department of Pharmacology, Addiction Science and Toxicology, the University of Tennessee Health Science Center, Memphis, TN, USA., Cheng K; Medical Informatics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Chiavellini P; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina., Choi OW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Clarke SM; AgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand., Cooper LN; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, USA., Cossette ML; Department of Environmental and Life Sciences, Trent University, Peterborough, Ontario, Canada., Day J; Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia., DeYoung J; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., DiRocco S; SeaWorld of Florida, Orlando, FL, USA., Dold C; Zoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA., Ehmke EE; Duke Lemur Center, Durham, NC, USA., Emmons CK; Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA., Emmrich S; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Erbay E; Altos Labs, San Francisco, CA, USA., Erlacher-Reid C; SeaWorld of Florida, Orlando, FL, USA.; SeaWorld Orlando, Orlando, FL, USA., Faulkes CG; School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Ferguson SH; Fisheries and Oceans Canada, Freshwater Institute, Winnipeg, Manitoba, Canada.; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Finno CJ; Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine, Davis, CA, USA., Flower JE; Mystic Aquarium, Mystic, CT, USA., Gaillard JM; Universite de Lyon, Universite Lyon 1, CNRS, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne, France., Garde E; Greenland Institute of Natural Resources, Nuuk, Greenland., Gerber L; Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, UNSW Sydney, Sydney, New South Wales, Australia., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gorbunova V; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Goya RG; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina., Grant MJ; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, the University of Auckland, Auckland, New Zealand., Green CB; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hales EN; Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine, Davis, CA, USA., Hanson MB; Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA., Hart DW; Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa., Haulena M; Vancouver Aquarium, Vancouver, British Columbia, Canada., Herrick K; SeaWorld of California, San Diego, CA, USA., Hogan AN; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Hogg CJ; School of Life and Environmental Sciences, the University of Sydney, Sydney, New South Wales, Australia., Hore TA; Department of Anatomy, University of Otago, Dunedin, New Zealand., Huang T; Division of Human Genetics, Department of Pediatrics, University at Buffalo, Buffalo, NY, USA.; Division of Genetics and Metabolism, Oishei Children's Hospital, Buffalo, NY, USA., Izpisua Belmonte JC; Altos Labs, San Diego Institute of Science, San Diego, CA, USA., Jasinska AJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Jones G; School of Biological Sciences, University of Bristol, Bristol, UK., Jourdain E; Norwegian Orca Survey, Andenes, Norway., Kashpur O; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA., Katcher H; Yuvan Research, Mountain View, CA, USA., Katsumata E; Kamogawa Sea World, Kamogawa, Japan., Kaza V; Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC, USA., Kiaris H; Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC, USA.; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA., Kobor MS; Edwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada., Kordowitzki P; Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.; Institute for Veterinary Medicine, Nicolaus Copernicus University, Torun, Poland., Koski WR; LGL Limited, King City, Ontario, Canada., Krützen M; Evolutionary Genetics Group, Department of Evolutionary Anthropology, University of Zurich, Zurich, Switzerland., Kwon SB; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Larison B; Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.; Center for Tropical Research, Institute for the Environment and Sustainability, UCLA, Los Angeles, CA, USA., Lee SG; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lehmann M; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina., Lemaitre JF; Universite de Lyon, Universite Lyon 1, CNRS, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne, France., Levine AJ; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Li C; Texas Pregnancy and Life-course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources, Laramie, WY, USA., Li X; Technology Center for Genomics and Bioinformatics, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Lim AR; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Lin DTS; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Lindemann DM; SeaWorld of Florida, Orlando, FL, USA., Little TJ; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Macoretta N; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Maddox D; White Oak Conservation, Yulee, FL, USA., Matkin CO; North Gulf Oceanic Society, Homer, AK, USA., Mattison JA; Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., McClure M; ABS Global, DeForest, WI, USA., Mergl J; Marineland of Canada, Niagara Falls, Ontario, Canada., Meudt JJ; Biomedical and Genomic Research Group, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA., Montano GA; Zoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA., Mozhui K; Department of Preventive Medicine, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA., Munshi-South J; Louis Calder Center-Biological Field Station, Department of Biological Sciences, Fordham University, Armonk, NY, USA., Naderi A; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA., Nagy M; Museum fur Naturkunde, Leibniz Institute for Evolution and Biodiversity Science, Berlin, Germany., Narayan P; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, the University of Auckland, Auckland, New Zealand., Nathanielsz PW; Texas Pregnancy and Life-course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources, Laramie, WY, USA., Nguyen NB; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Niehrs C; Institute of Molecular Biology, Mainz, Germany.; Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany., O'Brien JK; Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia., O'Tierney Ginn P; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.; Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA, USA., Odom DT; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Division of Regulatory Genomics and Cancer Evolution, Deutsches Krebsforschungszentrum, Heidelberg, Germany., Ophir AG; Department of Psychology, Cornell University, Ithaca, NY, USA., Osborn S; SeaWorld of Texas, San Antonio, TX, USA., Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Parsons KM; Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA., Paul KC; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Pellegrini M; Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA., Peters KJ; Evolutionary Genetics Group, Department of Evolutionary Anthropology, University of Zurich, Zurich, Switzerland.; School of Earth, Atmospheric and Life Sciences, University of Wollongong, Wollongong, Australia., Pedersen AB; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Petersen JL; Department of Animal Science, University of Nebraska, Lincoln, NE, USA., Pietersen DW; Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa., Pinho GM; Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA., Plassais J; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Poganik JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Prado NA; Department of Biology, College of Arts and Science, Adelphi University, Garden City, NY, USA., Reddy P; Altos Labs, San Diego Institute of Science, San Diego, CA, USA.; Salk Institute for Biological Studies, La Jolla, CA, USA., Rey B; Universite de Lyon, Universite Lyon 1, CNRS, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne, France., Ritz BR; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.; Department of Environmental Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, USA.; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Robbins J; Center for Coastal Studies, Provincetown, MA, USA., Rodriguez M; Miami Seaquarium, Miami, FL, USA., Russell J; SeaWorld of California, San Diego, CA, USA., Rydkina E; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Sailer LL; Department of Psychology, Cornell University, Ithaca, NY, USA., Salmon AB; The Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, UT Health San Antonio and the Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA., Sanghavi A; Yuvan Research, Mountain View, CA, USA., Schachtschneider KM; Department of Radiology, University of Illinois at Chicago, Chicago, IL, USA.; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.; National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Schmitt D; College of Agriculture, Missouri State University, Springfield, MO, USA., Schmitt T; SeaWorld of California, San Diego, CA, USA., Schomacher L; Institute of Molecular Biology, Mainz, Germany., Schook LB; Department of Radiology, University of Illinois at Chicago, Chicago, IL, USA.; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA., Sears KE; Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.; Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA., Seifert AW; Department of Biology, University of Kentucky, Lexington, KY, USA., Seluanov A; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Shafer ABA; Department of Forensic Science, Environmental and Life Sciences, Trent University, Peterborough, Ontario, Canada., Shanmuganayagam D; Biomedical and Genomic Research Group, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Shindyapina AV; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Simmons M; Duke Lemur Center, Durham, NC, USA., Singh K; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS University, Mumbai, India., Sinha I; Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA., Slone J; Division of Human Genetics, Department of Pediatrics, University at Buffalo, Buffalo, NY, USA., Snell RG; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, the University of Auckland, Auckland, New Zealand., Soltanmaohammadi E; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA., Spangler ML; Department of Animal Science, University of Nebraska, Lincoln, NE, USA., Spriggs MC; Busch Gardens Tampa, Tampa, FL, USA., Staggs L; SeaWorld of Florida, Orlando, FL, USA., Stedman N; Busch Gardens Tampa, Tampa, FL, USA., Steinman KJ; Species Preservation Laboratory, SeaWorld San Diego, San Diego, CA, USA., Stewart DT; Biology Department, Acadia University, Wolfville, Nova Scotia, Canada., Sugrue VJ; Department of Anatomy, University of Otago, Dunedin, New Zealand., Szladovits B; Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK., Takahashi JS; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA., Takasugi M; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Teeling EC; School of Biology and Environmental Science, University College Dublin, Dublin, Ireland., Thompson MJ; Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA., Van Bonn B; John G. Shedd Aquarium, Chicago, IL, USA., Vernes SC; School of Biology, the University of St Andrews, Fife, UK.; Neurogenetics of Vocal Communication Group, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands., Villar D; Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Vinters HV; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Wallingford MC; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.; Division of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA, USA., Wang N; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Wayne RK; Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA., Wilkinson GS; Department of Biology, University of Maryland, College Park, MD, USA., Williams CK; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Williams RW; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA., Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Yao M; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA., Young BG; Fisheries and Oceans Canada, Winnipeg, Manitoba, Canada., Zhang B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zhang Z; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Zhao P; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA., Zhao Y; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Zhou W; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zimmermann J; Department of Mathematics and Technology, University of Applied Sciences Koblenz, Koblenz, Germany., Ernst J; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Raj K; Altos Labs, Cambridge Institute of Science, Cambridge, UK., Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.; Altos Labs, San Diego Institute of Science, San Diego, CA, USA. shorvath@mednet.ucla.edu.; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.

Publikováno v: Nature aging [Nat Aging] 2023 Nov; Vol. 3 (11), pp. 1462.

We need to shift the focus of aging research to aging itself.

Autor: Poganik JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Sep 12; Vol. 120 (37), pp. e2307449120. Date of Electronic Publication: 2023 Sep 08.