Výsledky vyhledávání - "Podosome assembly"

Dock5 is a new regulator of microtubule dynamic instability in osteoclasts

Autor: Sarah Guimbal, Anne Morel, Anne Blangy, Manon Chardon, David Guérit, Virginie Vives

Publikováno v: Biology of the Cell
Biology of the Cell, Wiley, 2019, ⟨10.1111/boc.201900014⟩

BACKGROUND INFORMATION Osteoclast resorption is dependent on a podosome-rich structure called sealing zone. It tightly attaches the osteoclast to the bone creating a favourable acidic microenvironment for bone degradation. This adhesion structure nee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c756ac89774ceb7e2fb30aa4f48d9653
https://hal.archives-ouvertes.fr/hal-02276695/document

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Forces and constraints controlling podosome assembly and disassembly

Autor: Michael M. Kozlov, Gareth E. Jones, Nisha Bte Mohd Rafiq, Virgile Viasnoff, Alexander D. Bershadsky, Cheng Kai Lim, Gianluca Grenci

Publikováno v: Rafiq, N B M, Grenci, G, Lim, C K, Kozlov, M M, Jones, G E, Viasnoff, V & Bershadsky, A D 2019, ' Forces and constraints controlling podosome assembly and disassembly ', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1779, 20180228 . https://doi.org/10.1098/rstb.2018.0228
Philos Trans R Soc Lond B Biol Sci
Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2019, 374 (1779), pp.20180228. ⟨10.1098/rstb.2018.0228⟩

Podosomes are a singular category of integrin-mediated adhesions important in the processes of cell migration, matrix degradation and cancer cell invasion. Despite a wealth of biochemical studies, the effects of mechanical forces on podosome integrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd31d71d3194bc72d0844e56af882ad
https://kclpure.kcl.ac.uk/ws/files/114145387/Forces_and_constraints_controlling_RAFIQ_Accepted3April2019Publishedonline1July2019_GREEN_AAM.pdf

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Dock5 is a new regulator of microtubule dynamic instability through GSK3β inhibition in osteoclasts

Autor: Anne Blangy, David Guérit, Manon Chardon, Vives, Sarah Guimbal

Background informationOsteoclast resorption is dependent on a podosome-rich structure, called sealing zone, which is stabilized by acetylated microtubules. It tightly attaches the osteoclast to the bone creating a favorable acidic microenvironment fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56997857976f0da5dacbf9569a64a26
https://doi.org/10.1101/653055

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PLD-dependent phosphatidic acid microdomains are signaling platforms for podosome formation

Autor: Guangwei Du, Ben Joosten, Matteo Bolomini-Vittori, Jack A.M. Fransen, Svenja F. B. Mennens, Koen van den Dries, Alessandra Cambi

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports
Scientific Reports, 9

Local membrane phospholipid enrichment serves as docking platform for signaling proteins involved in many processes including cell adhesion and migration. Tissue-resident dendritic cells (DCs) assemble actomyosin-based structures called podosomes, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca738033a4c77ac1bf06747b837a0d80
https://doi.org/10.1038/s41598-019-39358-0

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Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO

Autor: Tingting Jiang, Cheng-han Yu, Zi Zhao Lieu, Paul Matsudaira, Gareth E. Jones, Alexander D. Bershadsky, Nisha Bte Mohd Rafiq

Publikováno v: The Journal of Cell Biology
Rafiq, N B M, Lieu, Z Z, Jiang, T, Yu, C H, Matsudaira, P, Jones, G E & Bershadsky, A D 2017, ' Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO ', The Journal of cell biology, vol. 216, no. 1, pp. 181-197 . https://doi.org/10.1083/jcb.201605104

Rafiq et al. demonstrate that the small G protein ARF1 and its activator, cytohesin 2 (ARNO), are required for podosome formation in macrophage-like cells and fibroblasts. Inhibition of ARNO-ARF1 signaling results in increased RhoA activity and disas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa34f6d185948895c1119f78fda6d7c
https://doi.org/10.1083/jcb.201605104

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Impaired endothelial shear stress induces podosome assemblyviaVEGF up‐regulation

Autor: Kai Michael Schubert, Theres Fey, Ulrich Pohl, Andreas Dendorfer, Holger Schneider, Evelyn Fein, Eike Christian Kleinert

Publikováno v: The FASEB Journal. 30:2755-2766

Podosomes are dynamic cytoskeletal membrane structures with local adhesive and proteolytic activity. They are critically involved in angiogenesis and vascular adaptive growth. Here, we studied in HUVECs and murine small vessels whether shear stress c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba0c369ec376b9636d1c9330039bcaf
https://doi.org/10.1096/fj.201500091r

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Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes

Autor: Mira Krendel, Zhen Feng, Yuhuan Zhou, Cheng-han Yu, Yage Zhang, Brian Sit, Fakun Cao

Publikováno v: Molecular Biology of the Cell
Zhang, Y, Cao, F, Zhou, Y, Feng, Z, Sit, B, Krendel, M, Yu, C & Drubin, D G (ed.) 2019, ' Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes ', Molecular biology of the cell, vol. 30, no. 5, pp. 622-635 . https://doi.org/10.1091/mbc.E18-06-0398

During podosome formation, distinct phosphatidylinositol 3,4,5-trisphosphate lipid (PI(3,4,5)P3) production and F-actin polymerization take place at integrin-mediated adhesions. Membrane-associated actin regulation factors, such as myosin-1, serve as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885d46177b9d6d32de258a79ce2d41af
https://pubmed.ncbi.nlm.nih.gov/30601698

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Forces and constraints controlling podosome assembly and disassembly

Autor: Gianluca Grenci, Virgile Viasnoff, Alexander D. Bershadsky, Nisha Bte Mohd Rafiq, Gareth E. Jones, Michael M. Kozlov

Podosomes are a singular category of integrin-mediated adhesions important in the processes of cell migration, matrix degradation, and cancer cell invasion. Despite a wealth of biochemical studies, the effects of mechanical forces on podosome integri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601328b4ff735b11d9b73c04cc7030fa
https://doi.org/10.1101/495176

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Emerging role of actin flow in the organization of podosomes in osteoclasts

Autor: Jiro Takito, Satoshi Inoue, Masanori Nakamura

Publikováno v: Macrophage. 4

The actin cytoskeleton plays a critical role in cell motility and the regulation of cell shape. One component of the actin cytoskeleton, the podosome, is involved in adhesion to the matrix, matrix degradation, cell migration, and mechanosensing of my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d05595793ebeeca82aa3a7f2cdedeb76
https://doi.org/10.14800/macrophage.1614

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