Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax.

Autor: Gaur, Tarang^1,2 (AUTHOR), Poddutoori, Ramulu³ (AUTHOR), Khare, Leena³ (AUTHOR), Bagal, Bhausaheb^2,4 (AUTHOR), Rashmi, Sonal^5,6 (AUTHOR), Patkar, Nikhil^2,7 (AUTHOR), Tembhare, Prashant^2,7 (AUTHOR), PG, Subramanian^2,7 (AUTHOR), Shetty, Dhanlaxmi^2,8 (AUTHOR), Dutt, Amit^2,5 (AUTHOR), Zhang, Qi⁹ (AUTHOR), Konopleva, Marina¹⁰ (AUTHOR), Platzbeckar, Uwe¹¹ (AUTHOR), Gupta, Sudeep^2,4 (AUTHOR), Samajdar, Susanta³ (AUTHOR), Ramchandra, Murali³ (AUTHOR), Khattry, Navin^2,4 (AUTHOR) nkhattry@gmail.com, Hasan, Syed K.^1,2 (AUTHOR) shasan@actrec.gov.in

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 7/29/2023, Vol. 42 Issue 1, p1-20. 20p.

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AML-444 A Covalent CDK7 Inhibitor Overcomes Venetoclax Resistance and Induces Apoptosis via C-Myc/p53 Axis in Acute Myeloid Leukemia

Autor: Gaur, Tarang, Poddutoori, Ramulu, Khare, Leena, Ramchandra, Murali, Khattry, Navin, Hasan, Syed K

Publikováno v: In Clinical Lymphoma, Myeloma and Leukemia September 2024 24 Supplement 1:S313-S314

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Discovery, design and synthesis of a selective S1P3 receptor allosteric agonist

Autor: Guerrero, Miguel, Poddutoori, Ramulu, Urbano, Mariangela, Peng, Xuemei, Spicer, Timothy P., Chase, Peter S., Hodder, Peter S., Schaeffer, Marie-Therese, Brown, Steven, Rosen, Hugh, Roberts, Edward

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 December 2013 23(23):6346-6349