Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Po Sing, Leung"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/7925b40a474341cdb07220566a928817
Autor:
Bao Chen Yang, Po Sing Leung
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 457-466 (2020)
Regulated cell death by way of ferroptosis involves iron-dependent accumulation of cellular reactive oxygen species (ROS). Ferroptosis is attracting attention as a potential therapeutic target for cancer treatments without drug resistance. The relati
Externí odkaz:
https://doaj.org/article/1e6e8746fb4040c794184f766f1c2034
Autor:
Xing Yu Li, Po Sing Leung
Publikováno v:
Cell Regeneration, Vol 9, Iss 1, Pp 1-9 (2020)
Abstract Ferroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactive oxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently proposed for cancer treatmen
Externí odkaz:
https://doaj.org/article/9fb3396373a649358aedac3716d9a414
Autor:
Ting Xie, PhD, Po Sing Leung, PhD
Publikováno v:
Journal of Pancreatology, Vol 3, Iss 1, Pp 29-34 (2020)
Abstract. In the past decades, skeletal muscle has become the focus of numerous studies due to its potential physiological role as an endocrine organ secreting hundreds of myokines. Among these myokines, fibroblast growth factor 21 (FGF21) and irisin
Externí odkaz:
https://doaj.org/article/da9333adf41b411c8ae36b7d92421d41
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 2, Pp 924-937 (2018)
Background/Aims: Islet metabolic disorder and inflammation contribute to the pathogenesis and progression of type 2 diabetes mellitus (T2DM). Irisin is a recently identified adipomyokine with protective effects on metabolic homeostasis and inflammati
Externí odkaz:
https://doaj.org/article/b1385ebc5b0b4d1cae8769ed4fc63e73
Autor:
Yuanfeng Chen, Dan Zhang, Ki Wai Ho, Sien Lin, Wade Chun-Wai Suen, Huantian Zhang, Zhengang Zha, Gang Li, Po Sing Leung
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background The aim of this study was to investigate the regulatory role of G-protein coupled receptor 120 (GPR120) in the development and progression of osteoarthritis (OA). Methods GPR120 knockout (KO) and wild-type (WT) mice were used to c
Externí odkaz:
https://doaj.org/article/d61cb45aa592419ca5370d8a962c91ed
Autor:
Zheng-Quan Lai, Siu-Po Ip, Hui-Jun Liao, Zheng Lu, Jian-Hui Xie, Zi-Ren Su, Yun-Long Chen, Yan-Fang Xian, Po-Sing Leung, Zhi-Xiu Lin
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer
Externí odkaz:
https://doaj.org/article/09ac414d13ed4563b2eedc6bf5adf465
Autor:
Po Sing Leung
Publikováno v:
Molecules, Vol 24, Iss 13, p 2479 (2019)
Vitamin D deficiency or hypovitaminosis D is associated with increased risks of insulin resistance, type 2 diabetes mellitus (T2DM) and its related non-alcoholic fatty liver disease (NAFLD). Meanwhile, inappropriate over-activation of the renin−ang
Externí odkaz:
https://doaj.org/article/af3be50a1d434ee28a978d4476f758b8
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147391 (2016)
The novel sodium glucose co-transporter 2 (SGLT2) inhibitor empagliflozin has recently been reported to improve glycemic control in streptozotocin-induced type 1 diabetic rats in an insulin-independent manner, via an increase in urinary glucose outpu
Externí odkaz:
https://doaj.org/article/32ea288b86ed4cb2989b7cc7a58f665c
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128216 (2015)
Angiotensin-converting enzyme 2 (ACE2), its product Angiotensin-(1-7) [Ang-(1-7)], and Ang-(1-7) receptor Mas, have been shown to regulate organogenesis during embryonic development in various species. However, it is not known whether a local ACE2/An
Externí odkaz:
https://doaj.org/article/7faaa7000ea348548f02caea612a4581