Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Po Chung Chan"'
Autor:
Chi Leung Chiang, Tai Chung Lam, James Chun Bong Li, Kenneth Sik Kwan Chan, Aya El Helali, Yolanda Yim Ping Lee, Laalaa Hiu Ting Law, Danyang Zheng, Anthony Wing Ip Lo, Ngar Woon Kam, Wing Sum Li, Alice Ka Wai Cheung, James Chung Hang Chow, Sunny Po Chung Chan, Jessica Wing Yu Lai, Sarah Wai Man Lee, Feng-Ming (Spring) Kong, Wai Tong Ng, Dora Lai Wan Kwong, Anne Wing Mui Lee
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 40, Iss , Pp 100898- (2023)
Summary: Background: The strategy of dual blockade of TGF-β and PD-L1 pathways has not been previously tested in platinum-refractory recurrent or metastatic nasopharyngeal cancer (R/M NPC) patients. This study aimed to evaluate the safety and effica
Externí odkaz:
https://doaj.org/article/8a4c0f1c23f14e66b633df5f0add5a87
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Table S7. Primary PK parameters for spartalizumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4654f298b3b5b95f2d1fe549d47835ec
https://doi.org/10.1158/1078-0432.22484064
https://doi.org/10.1158/1078-0432.22484064
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Figure S2. Adverse events in crossover group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28793f51c06cf4dd88863fe91eeb4c0b
https://doi.org/10.1158/1078-0432.22484097.v1
https://doi.org/10.1158/1078-0432.22484097.v1
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Table S2. Chemotherapy regimens given to patients in the chemotherapy arm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e697e4b2a33e6eb31107d28fe03682
https://doi.org/10.1158/1078-0432.22484082.v1
https://doi.org/10.1158/1078-0432.22484082.v1
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Table S5. Adverse events ({greater than or equal to} 15% incidence of all grades events in any of the patient treatment arms)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db369c8bd894b191faa792dd64a2b3a
https://doi.org/10.1158/1078-0432.22484070.v1
https://doi.org/10.1158/1078-0432.22484070.v1
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Table S6. Adverse events of special interest (patients treated with spartalizumab)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f0d6f1f0449b030b61c2ad5339b24d
https://doi.org/10.1158/1078-0432.22484067
https://doi.org/10.1158/1078-0432.22484067
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Purpose:No standard treatment exists for platinum-refractory, recurrent/metastatic nasopharyngeal cancer (NPC). This phase II study (NCT02605967) evaluated progression-free survival (PFS) of spartalizumab, an antiprogrammed cell death protein-1 (PD-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16654b198e7fddf4a1e74eebe9adc8c2
https://doi.org/10.1158/1078-0432.c.6531318
https://doi.org/10.1158/1078-0432.c.6531318
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Figure S3. Best percentage change from baseline in sum of diameters of target lesions for patients treated with spartalizumab (A) and chemotherapy (B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e129ac1ba81c71214802a67ed0d560d
https://doi.org/10.1158/1078-0432.22484088
https://doi.org/10.1158/1078-0432.22484088
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Table S1. Patient disposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d05607a694aad5f719edf7b9f542a4b
https://doi.org/10.1158/1078-0432.22484085.v1
https://doi.org/10.1158/1078-0432.22484085.v1
Autor:
Darren W-T. Lim, Luigi Manenti, Romain Séchaud, Jennifer Mataraza, Hongzi Liang, Yao Yao, Sebastian Szpakowski, Juan Gonzalez-Maffe, Steven McCune, Joël Guigay, Ammar Sukari, Alexander I. Spira, Zujun Li, Pei-Jen Lou, Victor H.F. Lee, Suebpong Tanasanvimon, Brigette B.Y. Ma, Somvilai Chakrabandhu, Po Chung Chan, Chia-Jui Yen, Li Zhang, Arunee Dechaphunkul, Roger K-C Ngan, Shau-Hsuan Li, Hung-Ming Wang, Caroline Even
Supplemental Figure S1. CONSORT diagram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3241828f2bbcae8bf4e25873af7fa979
https://doi.org/10.1158/1078-0432.22484100
https://doi.org/10.1158/1078-0432.22484100