Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Po Chu Kuo"'
Autor:
Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo
Publikováno v:
Journal of Medicinal Chemistry. 62:11135-11150
Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these
Autor:
Fu Ming Kuo, Chin Yu Lin, Chun Feng Chang, An Siou Li, Hsing Pang Hsieh, Teng Kuang Yeh, Jen Shin Song, Shu Yu Lin, Chun Hwa Chen, Mohane Selvaraj Coumar, Po Chu Kuo, Sing Yi Wang, Mu Chun Li, Wen-Hsing Lin, Chen Ming Yang, Pei Yi Chen, John T.A. Hsu
Publikováno v:
Bioorganic chemistry. 98
In an effort to develop new cancer therapeutics, we have reported clinical candidate BPR1K871 (1) as a potentanticancercompound in MOLM-13 and MV4-11 leukemia models, as well as in colorectal and pancreatic animal models. As BPR1K871 lacks oral bioav
Autor:
Chun-Ping Chang, Wen-Hsing Lin, Chun-Feng Chang, Jen-Shin Song, Pei-Yi Chen, Yi-Yu Ke, Wan-Ping Wang, Chuan Shih, Pei-Chen Wang, Po-Chu Kuo, Wen-Hsin Lin, Hsing Pang Hsieh, Chia-Hua Tsai, I-Chen Chiu, Ya-Hui Chi
Publikováno v:
European Journal of Medicinal Chemistry. 151:533-545
Twenty five novel chemical analogs of the previously reported Aurora kinase inhibitor BPR1K653 (1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea) have been designed, synthesized, and eva
Autor:
Manwu Sun, Teng-Kuang Yeh, Hsin-Yu Chang, Lun K. Tsou, Kuang-Feng Chu, Po-Chu Kuo, Chiung-Tong Chen, Jen-Shin Song, Yue-Zhi Lee, Yu-Wei Liu, Shiow-Ju Lee, Hsing-Yu Hsu, Cheng-Wei Yang, Chuan Shih, Yi-Yu Ke, Szu-Huei Wu, Li Mei Lin, Ching-Chuan Kuo
Publikováno v:
Journal of Medicinal Chemistry. 60:5599-5612
Humans have two glutaminase genes, GLS (GLS1) and GLS2, each of which has two alternative transcripts: the kidney isoform (KGA) and glutaminase C (GAC) for GLS, and the liver isoform (LGA) and glutaminase B (GAB) for GLS2. Initial hit compound (Z)-5-
Autor:
Wen Chieh Wang, Yun I. Chang, Fu Ming Kuo, Po Chu Kuo, Ching Ping Chen, Chiung-Tong Chen, Jen Shin Song, Mohane Selvaraj Coumar, Ching Chuan Kuo, Chun Wei Chang, An Siou Li, Ming Hsine Wu, Yi Yu Ke, Teng Kuang Yeh, Sing Yi Wang, Hui Yi Shiao, Kuei Jung Yen, Yung Chang Hsu, Chun Hwa Chen, Wen-Hsing Lin, Hsing Pang Hsieh, John T.A. Hsu, Pei Yi Chen, Chen Lung Huang, Chuan Shih
Publikováno v:
Oncotarget
// Yung Chang Hsu 1, * , Mohane Selvaraj Coumar 2, * , Wen-Chieh Wang 1, * , Hui-Yi Shiao 1, * , Yi-Yu Ke 1 , Wen-Hsing Lin 1 , Ching-Chuan Kuo 1 , Chun-Wei Chang 1 , Fu-Ming Kuo 1 , Pei-Yi Chen 1 , Sing-Yi Wang 1 , An-Siou Li 1 , Chun-Hwa Chen 1 , P
Autor:
John T.A. Hsu, Chun Hwa Chen, Hsing Pang Hsieh, Wen-Hsing Lin, Yih Shyan Lin, Biing-Jiun Uang, Chun Feng Chang, Wen Chieh Wang, Yi Yu Ke, Po Chu Kuo
Publikováno v:
European Journal of Medicinal Chemistry. 124:186-199
Aurora kinases have emerged as important anticancer targets so that there are several inhibitors have advanced into clinical study. Herein, we identified novel indazole derivatives as potent Aurora kinases inhibitors by utilizing in silico fragment-b
Autor:
Yi-Yu Ke, Jiing-Jyh Jan, Chen-Tso Tseng, Chen-Lung Huang, Kai-Chia Yeh, Ming-Chen Chou, Chiung-Tong Chen, Szu-Huei Wu, Chia-Jui Lee, Sing-Yi Wang, Lun K. Tsou, Jen-Shin Song, Kak-Shan Shia, Chien-Huang Wu, Po-Chu Kuo, Teng-Kuang Yeh, Hsuan‐Hao Kuan, Mine-Hsine Wu
Publikováno v:
Journal of medicinal chemistry. 61(3)
The function of the CXCR4/CXCL12 axis accounts for many disease indications, including tissue/nerve regeneration, cancer metastasis, and inflammation. Blocking CXCR4 signaling with its antagonists may lead to moving out CXCR4+ cell types from bone ma
Autor:
Kuei Jung Yen, Tsu Hsu, Ling Hui Chou, Yu Ling Huang, Yu-Sheng Chao, H. Eugene Liu, Cheng Tai Lu, Teng Kuang Yeh, Weir-Torn Jiaang, Jen Shin Song, Chun Hwa Chen, Po Chu Kuo, Ching Ping Chen, Shih Chieh Yen, Chiung-Tong Chen, Wen-Hsing Lin, Chen Lung Huang, John T.A. Hsu
Publikováno v:
European Journal of Medicinal Chemistry. 100:151-161
Numerous FLT3 inhibitors have been explored as a viable therapy for the treatment of acute myeloid leukemia (AML). However, clinical data have been underwhelming due to incomplete inhibition of FLT3 or the emergence of resistant mutations treated wit
Autor:
Yen-Ting Chen, Jen-Shin Song, Zhong-Wei Wu, Wan-Ping Wang, Chiun-Tong Chen, Po-Chu Kuo, Yi-Yu Ke, Ming-Chun Hung, Wen-Hsing Lin, Yu-Jie Su, Dai-Hui Jhuo, Chuan Shih, Ching-Ping Chen, Teng-Kuang Yeh, Ya-Hui Chi, Chun-Ping Chang, Chia-Hua Tsai
Publikováno v:
Cancer Research. 79:3851-3851
Small cell lung cancer (SCLC) is one the most aggressive tumors with poor survival rate. SCLC patients often present with metastasis at time of diagnosis, excluding surgery as a treatment option. While patients show high response rate to standard che
Autor:
Ming-Shiu Hung, Kak-Shan Shia, Ming-Chen Chou, Kun-Hung Chen, Po-Chu Kuo, Chen-Tso Tseng, Ying-Chieh Wong, Pei-Hsuan Chen, Shi-Liang Tseng, Teng-Kuang Yeh, Ming-Hung Ou, Jen-Shin Song, Kuei-Hua Chang, Yu-Sheng Chao, Chien-Huang Wu, Yinchiu Lin, Amit A. Sadani, Chun-Ping Chang
Publikováno v:
Journal of Medicinal Chemistry. 56:9920-9933
After extensive synthetic efforts, we found that many structurally diverse bioisosteres could be generated via derivatizing the C-4 alkyl chain on the pyrazole ring of compound 3 (B/P = 1/33) with different electronegative groups. Especially when a s